Ubiquitin and ubiquitin-like proteins in cancer pathogenesis (Q36601000)

15 August 2017

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title

Ubiquitin and ubiquitin-like proteins in cancer pathogenesis (English)

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15 August 2017

Ivan Dikic

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Daniela Hoeller

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15 August 2017

Christina-Maria Hecker

series ordinal

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15 August 2017

language of work or name

English

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publication date

1 October 2006

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15 August 2017

published in

Nature Reviews Cancer

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15 August 2017

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15 August 2017

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15 August 2017

page(s)

776-788

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15 August 2017

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Polyubiquitin chains: polymeric protein signals

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Ubiquitylation and cell signaling

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When ubiquitin meets ubiquitin receptors: a signalling connection

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Specification of SUMO1- and SUMO2-interacting motifs

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Ubiquitin-binding domains

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Identification of a SUMO-binding motif that recognizes SUMO-modified proteins

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Ubiquitin ligases: cell-cycle control and cancer

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p53 ubiquitination: Mdm2 and beyond

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The SCF ubiquitin ligase: insights into a molecular machine

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The Cbl interactome and its functions

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c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses

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A genomic and functional inventory of deubiquitinating enzymes

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De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

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SUMO in cancer--wrestlers wanted

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Immunoregulatory properties of ISG15, an interferon-induced cytokine

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Post-translational modification of p53 in tumorigenesis

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Cocompartmentalization of p53 and Mdm2 is a major determinant for Mdm2-mediated degradation of p53.

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Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.

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In vivo mitochondrial p53 translocation triggers a rapid first wave of cell death in response to DNA damage that can precede p53 target gene activation

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p53 has a direct apoptogenic role at the mitochondria

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The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

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Binding of p53 to the central domain of Mdm2 is regulated by phosphorylation

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A second p53 binding site in the central domain of Mdm2 is essential for p53 ubiquitination

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Gankyrin: a new oncoprotein and regulator of pRb and p53

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The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53

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Topors acts as a SUMO-1 E3 ligase for p53 in vitro and in vivo

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SUMO-1 modification activates the transcriptional response of p53

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Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.

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The E3 SUMO ligase PIASy is a regulator of cellular senescence and apoptosis

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A putative protein inhibitor of activated STAT (PIASy) interacts with p53 and inhibits p53-mediated transactivation but not apoptosis

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Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity

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MDM2-ARF complex regulates p53 sumoylation

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Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

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Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

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A dynamic role of HAUSP in the p53-Mdm2 pathway

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Association of a functional polymorphism in the promoter of the MDM2 gene with risk of nonsmall cell lung cancer

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The HAUSP gene plays an important role in non-small cell lung carcinogenesis through p53-dependent pathways

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Association between MDM2-SNP309 and age at colorectal cancer diagnosis according to p53 mutation status.

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NF-kappaB: linking inflammation and immunity to cancer development and progression

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Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs

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Ubiquitin signalling in the NF-kappaB pathway

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The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes

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Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO

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Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress

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PIDD mediates NF-kappaB activation in response to DNA damage

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NF-kappaB activation by combinations of NEMO SUMOylation and ATM activation stresses in the absence of DNA damage.

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PIASy mediates NEMO sumoylation and NF-kappaB activation in response to genotoxic stress.

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Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli

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SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation

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Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity

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A20 inhibits NF-kappaB activation by dual ubiquitin-editing functions

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A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells

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Identification of the familial cylindromatosis tumour-suppressor gene

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Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling

31 March 2020

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Analysis of DNA copy number aberrations in hepatitis C virus-associated hepatocellular carcinomas by conventional CGH and array CGH.

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Spiradenocylindroma of the kidney: clinical and genetic findings suggesting a role of somatic mutation of the CYLD1 gene in the oncogenesis of an unusual renal neoplasm

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Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB

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The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

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CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members

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Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation

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Trading places: how do DNA polymerases switch during translesion DNA synthesis?

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Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage

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Ubiquitylation of yeast proliferating cell nuclear antigen and its implications for translesion DNA synthesis

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Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis

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Controlling the subcellular localization of DNA polymerases iota and eta via interactions with ubiquitin

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Regulation of monoubiquitinated PCNA by DUB autocleavage

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Analysis of the role of ubiquitin-interacting motifs in ubiquitin binding and ubiquitylation

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The ubiquitin-interacting motifs target the endocytic adaptor protein epsin for ubiquitination

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A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins

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Regulation of ubiquitin-binding proteins by monoubiquitination

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Molecular analysis of mutations in DNA polymerase eta in xeroderma pigmentosum-variant patients

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Domain structure, localization, and function of DNA polymerase eta, defective in xeroderma pigmentosum variant cells

31 March 2020

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UBC13, a DNA-damage-inducible gene, is a member of the error-free postreplication repair pathway in Saccharomyces cerevisiae

31 March 2020

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Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair

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Lysine 63-polyubiquitination guards against translesion synthesis-induced mutations

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Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p

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SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase

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SUMO keeps a check on recombination during DNA replication.

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SUMO--nonclassical ubiquitin

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WNT and beta-catenin signalling: diseases and therapies

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Wnt signalling in stem cells and cancer

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Wnt signaling: is the party in the nucleus?

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Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity

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Roles of sumoylation of a reptin chromatin-remodelling complex in cancer metastasis

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Microarray analyses uncover UBE1L as a candidate target gene for lung cancer chemoprevention

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Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia

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Retinoid target genes in acute promyelocytic leukemia

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The development of proteasome inhibitors as anticancer drugs

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Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells

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Small molecule antagonists of the MDM2 oncoprotein as anticancer agents

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Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

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Comparison of in vitro anticancer-drug-screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines

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NMR indicates that the small molecule RITA does not block p53-MDM2 binding in vitro

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Drug discovery in the ubiquitin-proteasome system.

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Targeting Ubc9 for cancer therapy

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A role for Ubc9 in tumorigenesis

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A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

31 March 2020

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Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

31 March 2020

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Nuclear and unclear functions of SUMO

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Ubiquitin: structures, functions, mechanisms

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Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinases

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Ubiquitination on nonlysine residues by a viral E3 ubiquitin ligase

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Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology

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FAT10, a ubiquitin-independent signal for proteasomal degradation

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Knockdown of Skp2 by siRNA inhibits melanoma cell growth in vitro and in vivo

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Expression of Skp2, a p27(Kip1) ubiquitin ligase, in malignant lymphoma: correlation with p27(Kip1) and proliferation index

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Anaphase-promoting complex-dependent proteolysis of cell cycle regulators and genomic instability of cancer cells

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A novel ubiquitin ligase is deficient in Fanconi anemia

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cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas

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Aberrant expression of HOXA9, DEK, CBL and CSF1R in acute myeloid leukemia

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Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional t(12;15)(q13;q25).

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Two-step differential expression analysis reveals a new set of genes involved in thyroid oncocytic tumors

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Viral oncoproteins E1A and E7 and cellular LxCxE proteins repress SUMO modification of the retinoblastoma tumor suppressor

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Localization of phosphorylated forms of Bcl-2 in mitosis: co-localization with Ki-67 and nucleolin in nuclear structures and on mitotic chromosomes.

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DNA microarray analysis of stage progression mechanism in myelodysplastic syndrome

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Isolation of differentially expressed genes in NPM-ALK-positive anaplastic large cell lymphoma

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Transactivation of peroxisome proliferator-activated receptor alpha by green tea extracts.

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Proteomic analysis of normal and malignant prostate tissue to identify novel proteins lost in cancer

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Expression of the FAT10 gene is highly upregulated in hepatocellular carcinoma and other gastrointestinal and gynecological cancers

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Elevated expression of ISG15 in tumor cells interferes with the ubiquitin/26S proteasome pathway.

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A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme

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Autocrine antiapoptotic stimulation of cultured adult T-cell leukemia cells by overexpression of the chemokine I-309.

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Stage-associated overexpression of the ubiquitin-like protein, ISG15, in bladder cancer

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Identification of the chimeric protein product of the CBFB-MYH11 fusion gene in inv(16) leukemia cells

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The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCFSkp2 ubiquitin ligase

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Identifiers

DOI

10.1038/NRC1994

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15 August 2017

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