The Cbl interactome and its functions (Q28277251)

Untangling the ErbB signalling network

21 January 2018

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Signaling networks: the origins of cellular multitasking

21 January 2018

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Compartmentalization of growth factor receptor signalling

21 January 2018

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Cbl: many adaptations to regulate protein tyrosine kinases

21 January 2018

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v-cbl, an oncogene from a dual-recombinant murine retrovirus that induces early B-lineage lymphomas

21 January 2018

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cbl-3: a new mammalian cbl family protein

21 January 2018

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Molecular cloning and characterization of a novel cbl-family gene, cbl-c

21 January 2018

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Cbl-3-deficient mice exhibit normal epithelial development

21 January 2018

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Themes and variations on ubiquitylation

21 January 2018

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Protein regulation by monoubiquitin

21 January 2018

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When ubiquitin meets ubiquitin receptors: a signalling connection

21 January 2018

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Cbl signaling networks in the regulation of cell function

21 January 2018

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Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation

21 January 2018

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Coupling of the Proto-oncogene Product c-Cbl to the Epidermal Growth Factor Receptor

21 January 2018

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LET-23-mediated signal transduction during Caenorhabditis elegans development

21 January 2018

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21 January 2018

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The cbl oncogene: a novel substrate of protein tyrosine kinases

21 January 2018

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Ligand-induced, receptor-mediated dimerization and activation of EGF receptor

21 January 2018

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Grb2 regulates internalization of EGF receptors through clathrin-coated pits

21 January 2018

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Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins

21 January 2018

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Direct interaction of Cbl with pTyr 1045 of the EGF receptor (EGFR) is required to sort the EGFR to lysosomes for degradation

21 January 2018

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The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

21 January 2018

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Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

21 January 2018

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Negative receptor signalling

21 January 2018

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CIN85/CMS family of adaptor molecules

21 January 2018

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The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met

21 January 2018

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Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors

21 January 2018

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A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton

21 January 2018

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Receptor endocytosis via ubiquitin-dependent and -independent pathways

21 January 2018

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Clathrin-independent endocytosis of ubiquitinated cargos

21 January 2018

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Cbl-mediated Ubiquitinylation Is Required for Lysosomal Sorting of Epidermal Growth Factor Receptor but Is Dispensable for Endocytosis

21 January 2018

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The role of phosphoinositides in membrane transport

21 January 2018

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Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein

21 January 2018

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Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion

21 January 2018

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CIN85 associates with multiple effectors controlling intracellular trafficking of epidermal growth factor receptors

21 January 2018

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21 January 2018

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Rab proteins as membrane organizers

21 January 2018

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Interaction of the c-cbl proto-oncogene product with the Tyk-2 protein tyrosine kinase

21 January 2018

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WW domain HECT E3s target Cbl RING finger E3s for proteasomal degradation

21 January 2018

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Src promotes destruction of c-Cbl: implications for oncogenic synergy between Src and growth factor receptors

21 January 2018

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Src-catalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins

21 January 2018

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Epidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalization

21 January 2018

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Modulation of signalling by Sprouty: a developing story

21 January 2018

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Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation

21 January 2018

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Activated Cdc42 Sequesters c-Cbl and Prevents EGF Receptor Degradation

21 January 2018

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Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases

21 January 2018

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Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2

21 January 2018

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Src phosphorylation of Alix/AIP1 modulates its interaction with binding partners and antagonizes its activities

21 January 2018

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Alix/AIP1 antagonizes epidermal growth factor receptor downregulation by the Cbl-SETA/CIN85 complex.

21 January 2018

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AIP1/ALIX Is a Binding Partner for HIV-1 p6 and EIAV p9 Functioning in Virus Budding

21 January 2018

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The immunological synapse balances T cell receptor signaling and degradation

21 January 2018

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Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling.

21 January 2018

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Adaptor proteins in lymphocyte activation.

21 January 2018

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SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling

21 January 2018

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Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes

21 January 2018

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Phosphotyrosine Binding Domain-Dependent Upregulation of the Platelet-Derived Growth Factor Receptor α Signaling Cascade by Transforming Mutants of Cbl: Implications for Cbl’s Function and Oncogenicity

21 January 2018

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Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function

21 January 2018

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The non-receptor tyrosine kinase Syk is a target of Cbl-mediated ubiquitylation upon B-cell receptor stimulation.

21 January 2018

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Cbl-b negatively regulates B cell antigen receptor signaling in mature B cells through ubiquitination of the tyrosine kinase Syk.

21 January 2018

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Cbl promotes ubiquitination of the T cell receptor zeta through an adaptor function of Zap-70.

21 January 2018

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Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.

21 January 2018

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c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation

21 January 2018

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Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice

21 January 2018

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Altered thymic positive selection and intracellular signals in Cbl-deficient mice

21 January 2018

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Cbl-b regulates the CD28 dependence of T-cell activation.

21 January 2018

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A mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinase

21 January 2018

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Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells

21 January 2018

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Molecular controls of antigen receptor clustering and autoimmunity

21 January 2018

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70Z/3 Cbl induces PLCγ1 activation in T lymphocytes via an alternate Lat- and Slp-76-independent signaling mechanism

21 January 2018

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Cbl suppresses B cell receptor-mediated phospholipase C (PLC)-gamma2 activation by regulating B cell linker protein-PLC-gamma2 binding

21 January 2018

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Cbl-b positively regulates Btk-mediated activation of phospholipase C-gamma2 in B cells

21 January 2018

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E3 ubiquitin ligases as T cell anergy factors.

21 January 2018

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Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction.

21 January 2018

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Serine phosphorylation of Cbl induced by phorbol ester enhances its association with 14-3-3 proteins in T cells via a novel serine-rich 14-3-3-binding motif

21 January 2018

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21 January 2018

Nuclear lipid signalling

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Cbl-b interacts with ubiquitinated proteins; differential functions of the UBA domains of c-Cbl and Cbl-b

21 January 2018

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The multi-adaptor proto-oncoprotein Cbl is a key regulator of Rac and actin assembly

21 January 2018

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Phosphorylation- and activation-independent association of the tyrosine kinase Syk and the tyrosine kinase substrates Cbl and Vav with tubulin in B-cells

21 January 2018

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Rapid microtubule-dependent induction of neurite-like extensions in NIH 3T3 fibroblasts by inhibition of ROCK and Cbl

21 January 2018

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The biogenesis of multivesicular endosomes

21 January 2018

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The proto-oncogene product p120(cbl) links c-Src and phosphatidylinositol 3'-kinase to the integrin signaling pathway.

21 January 2018

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Regulation of beta 1-integrin-mediated cell adhesion by the Cbl adaptor protein

21 January 2018

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A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration

21 January 2018

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c-Cbl is downstream of c-Src in a signalling pathway necessary for bone resorption.

21 January 2018

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Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases

21 January 2018

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Fyn, Yes, and Syk phosphorylation sites in c-Cbl map to the same tyrosine residues that become phosphorylated in activated T cells

21 January 2018

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Physical and functional association of the cbl protooncogen product with an src-family protein tyrosine kinase, p53/56lyn, in the B cell antigen receptor-mediated signaling

21 January 2018

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Cbl-mediated ubiquitinylation and negative regulation of Vav.

21 January 2018

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APS facilitates c-Cbl tyrosine phosphorylation and GLUT4 translocation in response to insulin in 3T3-L1 adipocytes

21 January 2018

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Requirements for pYXXM motifs in Cbl for binding to the p85 subunit of phosphatidylinositol 3-kinase and Crk, and activation of atypical protein kinase C and glucose transport during insulin action in 3T3/L1 adipocytes

21 January 2018

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Cbl PYXXM motifs activate the P85 subunit of phosphatidylinositol 3-kinase, Crk, atypical protein kinase C, and glucose transport during thiazolidinedione action in 3T3/L1 and human adipocytes

21 January 2018

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A role for CAP, a novel, multifunctional Src homology 3 domain-containing protein in formation of actin stress fibers and focal adhesions

21 January 2018

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Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl

21 January 2018

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SETA/CIN85/Ruk and its binding partner AIP1 associate with diverse cytoskeletal elements, including FAKs, and modulate cell adhesion

21 January 2018

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The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction

21 January 2018

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Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites

21 January 2018

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Complexes of focal adhesion kinase (FAK) and Crk-associated substrate (p130(Cas)) are elevated in cytoskeleton-associated fractions following adhesion and Src transformation. Requirements for Src kinase activity and FAK proline-rich motifs

21 January 2018

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Cbl associates with Pyk2 and Src to regulate Src kinase activity, alpha(v)beta(3) integrin-mediated signaling, cell adhesion, and osteoclast motility

21 January 2018

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Newest findings on the oldest oncogene; how activated src does it

21 January 2018

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Activation of R-Ras by Ras-Guanine Nucleotide-releasing Factor

21 January 2018

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Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10

21 January 2018

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Insulin-stimulated GLUT4 translocation in adipocytes is dependent upon cortical actin remodeling

21 January 2018

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Mechanisms underlying ubiquitination

21 January 2018

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Tal, a Tsg101-specific E3 ubiquitin ligase, regulates receptor endocytosis and retrovirus budding

21 January 2018

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The GRID: the General Repository for Interaction Datasets

21 January 2018

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Osprey: a network visualization system

21 January 2018

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Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

21 January 2018

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Proteolysis: from the lysosome to ubiquitin and the proteasome

21 January 2018

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Tyrosine phosphorylation and translocation of the c-cbl protein after activation of tyrosine kinase signaling pathways

31 March 2020

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20 years of Ins(1,4,5)P3, and 40 years before

31 March 2020

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