The SCF ubiquitin ligase: insights into a molecular machine (Q28279993)

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1 January 2020

review article

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title

The SCF ubiquitin ligase: insights into a molecular machine (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15340381%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15340381%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

Timothy Cardozo

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1 January 2020

language of work or name

English

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publication date

1 September 2004

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Nature Reviews Molecular Cell Biology

1 January 2020

published in

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volume

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issue

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1 January 2020

page(s)

739-751

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SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

1 January 2020

cites work

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A Complex of Cdc4p, Skp1p, and Cdc53p/Cullin Catalyzes Ubiquitination of the Phosphorylated CDK Inhibitor Sic1p

21 April 2017

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F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex

21 April 2017

1 reference

Identification of a family of human F-box proteins

21 April 2017

1 reference

A family of mammalian F-box proteins

21 April 2017

1 reference

The WD repeat: a common architecture for diverse functions

21 April 2017

1 reference

The leucine-rich repeat as a protein recognition motif

21 April 2017

1 reference

Structural principles of leucine-rich repeat (LRR) proteins

21 April 2017

1 reference

E3 ubiquitin ligase that recognizes sugar chains

21 April 2017

1 reference

Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains

21 April 2017

1 reference

E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1)

21 April 2017

1 reference

Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex

21 April 2017

1 reference

A novel member of the F-box/WD40 gene family, encoding dactylin, is disrupted in the mouse dactylaplasia mutant

21 April 2017

1 reference

CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex

21 April 2017

1 reference

Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis

21 April 2017

1 reference

Molecular profile of synovial fibroblasts in rheumatoid arthritis depends on the stage of proliferation.

21 April 2017

1 reference

Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy

21 April 2017

1 reference

Identification of ubiquitin ligases required for skeletal muscle atrophy

21 April 2017

1 reference

Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication

21 April 2017

1 reference

p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27

21 April 2017

1 reference

Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase

21 April 2017

1 reference

Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase

21 April 2017

1 reference

Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex

21 April 2017

1 reference

Dual mode of degradation of Cdc25 A phosphatase

21 April 2017

1 reference

Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins

21 April 2017

1 reference

Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage

21 April 2017

1 reference

SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase

21 April 2017

1 reference

Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase

21 April 2017

1 reference

Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines

21 April 2017

1 reference

Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line

21 April 2017

1 reference

M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP

21 April 2017

1 reference

Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo

21 April 2017

1 reference

Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase

21 April 2017

1 reference

Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation

21 April 2017

1 reference

Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome

21 April 2017

1 reference

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

21 April 2017

1 reference

Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

21 April 2017

1 reference

Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex

21 April 2017

1 reference

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

21 April 2017

1 reference

Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase

21 April 2017

1 reference

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

21 April 2017

1 reference

Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

21 April 2017

1 reference

Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade

21 April 2017

1 reference

Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase

21 April 2017

1 reference

Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase

21 April 2017

1 reference

The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase

21 April 2017

1 reference

An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin

21 April 2017

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The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin.

21 April 2017

1 reference

F-box protein Grr1 interacts with phosphorylated targets via the cationic surface of its leucine-rich repeat

21 April 2017

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The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27

21 April 2017

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A negatively charged amino acid in Skp2 is required for Skp2-Cks1 interaction and ubiquitination of p27Kip1

21 April 2017

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Protein-protein interactions involved in the recognition of p27 by E3 ubiquitin ligase

21 April 2017

1 reference

Structural studies of p21Waf1/Cip1/Sdi1 in the free and Cdk2-bound state: conformational disorder mediates binding diversity

21 April 2017

1 reference

Intrinsic structural disorder and sequence features of the cell cycle inhibitor p57Kip2

21 April 2017

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p27 binds cyclin-CDK complexes through a sequential mechanism involving binding-induced protein folding

21 April 2017

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Three different binding sites of Cks1 are required for p27-ubiquitin ligation

21 April 2017

1 reference

Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1

21 April 2017

1 reference

Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex

21 April 2017

1 reference

Functional interaction of 13 yeast SCF complexes with a set of yeast E2 enzymes in vitro

21 April 2017

1 reference

Back to the future with ubiquitin

21 April 2017

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The F-box protein family.

21 April 2017

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Protein interaction analysis of SCF ubiquitin E3 ligase subunits from Arabidopsis

21 April 2017

1 reference

A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity

21 April 2017

1 reference

Binding of small molecules to an adaptive protein-protein interface

21 April 2017

1 reference

Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts

21 April 2017

1 reference

Small molecule modulation of Smoothened activity

21 April 2017

1 reference

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

21 April 2017

1 reference

Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy

21 April 2017

1 reference

Proteasomes and their kin: proteases in the machine age

21 April 2017

1 reference

Oncogenic aberrations of cullin-dependent ubiquitin ligases

21 April 2017

1 reference

A novel cyclin gene (CCNF) in the region of the polycystic kidney disease gene (PKD1).

21 January 2018

1 reference

21 January 2018

Recycling the Cell Cycle

1 reference

Proviral insertions in the zebrafish hagoromo gene, encoding an F-box/WD40-repeat protein, cause stripe pattern anomalies

21 January 2018

1 reference

Split hand foot malformation is associated with a reduced level of Dactylin gene expression

21 January 2018

1 reference

Split-hand/split-foot malformation is caused by mutations in the p63 gene on 3q27.

21 January 2018

1 reference

The spindle checkpoint: structural insights into dynamic signalling

21 January 2018

1 reference

The anaphase-promoting complex: proteolysis in mitosis and beyond

21 January 2018

1 reference

Skp2-mediated degradation of p27 regulates progression into mitosis

21 January 2018

1 reference

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

21 January 2018

1 reference

p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

21 January 2018

1 reference

Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins

21 January 2018

1 reference

Loss of the anaphase-promoting complex in quiescent cells causes unscheduled hepatocyte proliferation

21 January 2018

1 reference

Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC.

21 January 2018

1 reference

Ratchets and clocks: the cell cycle, ubiquitylation and protein turnover

21 January 2018

1 reference

Phosphorylation-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1

21 January 2018

1 reference

COP9 signalosome: a multifunctional regulator of SCF and other cullin-based ubiquitin ligases

21 January 2018

1 reference

The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase.

21 January 2018

1 reference

BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.

21 January 2018

1 reference

Targeting of protein ubiquitination by BTB–Cullin 3–Roc1 ubiquitin ligases

21 January 2018

1 reference

The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell.

21 January 2018

1 reference

Culprits in the degradation of cyclin E apprehended

21 January 2018

1 reference

Context of multiubiquitin chain attachment influences the rate of Sic1 degradation

21 January 2018

1 reference

Mathematical modeling suggests cooperative interactions between a disordered polyvalent ligand and a single receptor site

21 January 2018

1 reference

A CDK-independent function of mammalian Cks1: targeting of SCF(Skp2) to the CDK inhibitor p27Kip1.

21 January 2018

1 reference

Functional consequences of preorganized helical structure in the intrinsically disordered cell-cycle inhibitor p27(Kip1).

21 January 2018

1 reference

Structural basis of sugar-recognizing ubiquitin ligase

21 January 2018

1 reference

Proteasome-mediated degradation of p21 via N-terminal ubiquitinylation.

21 January 2018

1 reference

IkappaBalpha ubiquitination is catalyzed by an SCF-like complex containing Skp1, cullin-1, and two F-box/WD40-repeat proteins, betaTrCP1 and betaTrCP2.

21 January 2018

1 reference

Release of ubiquitin-charged Cdc34-S - Ub from the RING domain is essential for ubiquitination of the SCF(Cdc4)-bound substrate Sic1.

21 January 2018

1 reference

Cdc34 self-association is facilitated by ubiquitin thiolester formation and is required for its catalytic activity

21 January 2018

1 reference

Nedd8 on cullin: building an expressway to protein destruction.

21 January 2018

1 reference

The F-box protein Skp2 is a ubiquitylation target of a Cul1-based core ubiquitin ligase complex: evidence for a role of Cul1 in the suppression of Skp2 expression in quiescent fibroblasts

21 January 2018

1 reference

Stability of homologue of Slimb F-box protein is regulated by availability of its substrate

21 January 2018

1 reference

When protein destruction runs amok, malignancy is on the loose

21 January 2018

1 reference

Basic Medical Research Award. The ubiquitin system

21 January 2018

1 reference

Ubiquitin ligases and the immune response

21 January 2018

1 reference

The Caenorhabditis elegans Skp1-related gene family: diverse functions in cell proliferation, morphogenesis, and meiosis

21 January 2018

1 reference

Multiple Skp1-related proteins in Caenorhabditis elegans: diverse patterns of interaction with Cullins and F-box proteins

21 January 2018

1 reference

Small-molecule antagonists of the oncogenic Tcf/beta-catenin protein complex

21 January 2018

1 reference

Inhibition of protein-protein association by small molecules: approaches and progress

21 January 2018

1 reference

Protein-protein interfaces: mimics and inhibitors

21 January 2018

1 reference

Mutagenic analysis of the roles of SH2 and SH3 domains in regulation of the Abl tyrosine kinase

21 January 2018

1 reference

21 January 2018

1 reference

The small heat-shock protein alpha B-crystallin promotes FBX4-dependent ubiquitination

31 March 2020

1 reference

Whose end is destruction: cell division and the anaphase-promoting complex

31 March 2020

1 reference

Dynamics of the cell cycle: checkpoints, sizers, and timers

31 March 2020

1 reference

CDK inhibitors: positive and negative regulators of G1-phase progression

31 March 2020

1 reference

Kip1 meets SKP2: new links in cell-cycle control

31 March 2020

1 reference

Cyclin E-CDK2 is a regulator of p27Kip1.

31 March 2020

1 reference

Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation

31 March 2020

1 reference

BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases

31 March 2020

1 reference

The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

31 March 2020

1 reference

Rapid degradation of the G1 cyclin Cln2 induced by CDK-dependent phosphorylation

31 March 2020

1 reference

Cooperative organization in a macromolecular complex

31 March 2020

1 reference

Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases

31 March 2020

1 reference

The F box protein AFR is a positive regulator of phytochrome A-mediated light signaling

31 March 2020

1 reference

The Arabidopsis SKP1-like genes present a spectrum of expression profiles

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRM1471

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Consolidated OpenCitations Corpus – April 2017

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Dimensions Publication ID

1 January 2020

1000525154

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Consolidated OpenCitations Corpus – April 2017

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Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15340381%20AND%20SRC:MED&resulttype=core&format=json