COSMID: A Web-based Tool for Identifying and Validating CRISPR/Cas Off-target Sites (Q34745306)

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English	COSMID: A Web-based Tool for Identifying and Validating CRISPR/Cas Off-target Sites	scientific article

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scholarly article

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PubMed publication ID

25462530

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4 August 2017

title

COSMID: A Web-based Tool for Identifying and Validating CRISPR/Cas Off-target Sites (English)

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Europe PubMed Central

PubMed publication ID

25462530

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4 August 2017

main subject

CRISPR

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author

Eli J Fine

object named as

Eli J Fine

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4

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Ciaran M Lee

object named as

Ciaran M Lee

series ordinal

3

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Thomas J. Cradick

object named as

Thomas J Cradick

series ordinal

1

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author name string

Peng Qiu

series ordinal

2

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Europe PubMed Central

PubMed publication ID

25462530

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4 August 2017

Gang Bao

series ordinal

5

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stated in

Europe PubMed Central

PubMed publication ID

25462530

retrieved

4 August 2017

publication date

2 December 2014

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Europe PubMed Central

PubMed publication ID

25462530

retrieved

4 August 2017

published in

Molecular Therapy. Nucleic acids

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stated in

Europe PubMed Central

PubMed publication ID

25462530

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4 August 2017

volume

3

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Europe PubMed Central

PubMed publication ID

25462530

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4 August 2017

page(s)

e214

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PubMed publication ID

25462530

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4 August 2017

describes a project that uses

ImageJ

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Europe PubMed Central

retrieved

11 June 2022

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4272406/fullTextXML

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cites work

CHOPCHOP: a CRISPR/Cas9 and TALEN web tool for genome editing

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CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences

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7 July 2018

Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing

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7 July 2018

Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification

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7 July 2018

Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases

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An online bioinformatics tool predicts zinc finger and TALE nuclease off-target cleavage

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Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity

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Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system

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Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis

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CRISPR/Cas9 systems targeting β-globin and CCR5 genes have substantial off-target activity

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High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity

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7 July 2018

DNA targeting specificity of RNA-guided Cas9 nucleases

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7 July 2018

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

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Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish.

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ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

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7 July 2018

Protospacer recognition motifs: mixed identities and functional diversity

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7 July 2018

RNA-programmed genome editing in human cells

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7 July 2018

RNA-guided editing of bacterial genomes using CRISPR-Cas systems

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7 July 2018

RNA-guided human genome engineering via Cas9

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7 July 2018

Multiplex genome engineering using CRISPR/Cas systems

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7 July 2018

Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

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PubMed Central

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7 July 2018

An archaeal immune system can detect multiple protospacer adjacent motifs (PAMs) to target invader DNA.

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PubMed Central

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7 July 2018

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

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7 July 2018

FLASH assembly of TALENs for high-throughput genome editing

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7 July 2018

Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects

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7 July 2018

A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity.

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7 July 2018

Genetic engineering of human pluripotent cells using TALE nucleases

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7 July 2018

ZFN-site searches genomes for zinc finger nuclease target sites and off-target sites.

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PubMed Central

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7 July 2018

The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA

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7 July 2018

A rapid and general assay for monitoring endogenous gene modification

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7 July 2018

Quantification of zinc finger nuclease-associated toxicity

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PubMed Central

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7 July 2018

ZiFiT (Zinc Finger Targeter): an updated zinc finger engineering tool

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7 July 2018

CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea

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7 July 2018

CRISPR/Cas, the immune system of bacteria and archaea

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7 July 2018

RNA-guided RNA cleavage by a CRISPR RNA-Cas protein complex

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7 July 2018

CRISPI: a CRISPR interactive database

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7 July 2018

Short motif sequences determine the targets of the prokaryotic CRISPR defence system

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7 July 2018

Small CRISPR RNAs guide antiviral defense in prokaryotes

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7 July 2018

Diversity, activity, and evolution of CRISPR loci in Streptococcus thermophilus

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7 July 2018

Indexing strategies for rapid searches of short words in genome sequences.

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7 July 2018

CRISPR Recognition Tool (CRT): a tool for automatic detection of clustered regularly interspaced palindromic repeats

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7 July 2018

CRISPRFinder: a web tool to identify clustered regularly interspaced short palindromic repeats

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7 July 2018

The CRISPRdb database and tools to display CRISPRs and to generate dictionaries of spacers and repeats

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7 July 2018

CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes

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7 July 2018

Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extrachromosomal origin

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7 July 2018

Accelerating genome editing in CHO cells using CRISPR Cas9 and CRISPy, a web-based target finding tool

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26 October 2018

CasOT: a genome-wide Cas9/gRNA off-target searching tool

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26 October 2018

Knockout rats generated by embryo microinjection of TALENs.

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26 October 2018

Identifiers

DOI

10.1038/MTNA.2014.64

1 reference

stated in

Europe PubMed Central

PubMed publication ID

25462530

retrieved

4 August 2017

PMC publication ID

4272406

1 reference

stated in

Europe PubMed Central

PubMed publication ID

25462530

retrieved

4 August 2017

PubMed publication ID

25462530

1 reference

stated in

Europe PubMed Central

PubMed publication ID

25462530

retrieved

4 August 2017

ResearchGate publication ID

269174664

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