Histocompatibility minor 13 (Q21102548)

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mammalian protein found in Homo sapiens

• minor histocompatibility antigen H13
• presenilin-like protein 3
• intramembrane protease 1
• hIMP1
• IMPAS-1
• signal peptide peptidase like 1
• Signal peptide peptidase
• minor histocompatibility antigen 13
• HM13
• IMP-1
• signal peptide peptidase beta

edit

Language	Label	Description	Also known as
English	Histocompatibility minor 13	mammalian protein found in Homo sapiens	minor histocompatibility antigen H13 presenilin-like protein 3 intramembrane protease 1 hIMP1 IMPAS-1 signal peptide peptidase like 1 Signal peptide peptidase minor histocompatibility antigen 13 HM13 IMP-1 signal peptide peptidase beta

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

18 July 2018

UniProt protein ID

Q8TCT9

part of

Peptidase A22B, signal peptide peptidase

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q8TCT9

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

18 July 2018

UniProt protein ID

Q8TCT9

encoded by

HM13

1 reference

stated in

UniProt

retrieved

18 July 2018

UniProt protein ID

Q8TCT9

molecular function

protein homodimerization activity

determination method or standard

IDA

3 references

retrieved

8 April 2019

stated in

Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IDA

retrieved

8 April 2019

stated in

Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IDA

retrieved

8 April 2019

stated in

Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IDA

aspartic-type endopeptidase activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IEA

aspartic endopeptidase activity, intramembrane cleaving

determination method or standard

IDA

IMP

2 references

retrieved

26 September 2017

stated in

Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT9&geneProductId=UniProtKB:Q8TCT9

determination method or standard

IMP

retrieved

26 September 2017

stated in

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT9&geneProductId=UniProtKB:Q8TCT9

determination method or standard

IDA

peptidase activity

determination method or standard

IDA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IEA

retrieved

8 April 2019

stated in

Impas 1 possesses endoproteolytic activity against multipass membrane protein substrate cleaving the presenilin 1 holoprotein

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IDA

protein binding

determination method or standard

IPI

5 references

retrieved

8 April 2019

stated in

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IPI

retrieved

8 April 2019

stated in

The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IPI

retrieved

8 April 2019

stated in

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IPI

retrieved

8 April 2019

stated in

Protein disulphide isomerase is required for signal peptide peptidase-mediated protein degradation

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IPI

retrieved

8 April 2019

stated in

A proteome-scale map of the human interactome network

GOA

curator

IntAct protein interaction database

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IPI

hydrolase activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IEA

ubiquitin protein ligase binding

determination method or standard

IPI

1 reference

retrieved

8 April 2019

stated in

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IPI

aspartic endopeptidase activity, intramembrane cleaving

determination method or standard

IBA

IDA

IMP

3 references

retrieved

8 April 2019

stated in

Intramembrane proteolytic cleavage by human signal peptide peptidase like 3 and malaria signal peptide peptidase

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IMP

retrieved

8 April 2019

stated in

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IBA

cell component

integral component of membrane

determination method or standard

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IEA

rough endoplasmic reticulum

determination method or standard

IDA

2 references

retrieved

8 April 2019

stated in

Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IDA

retrieved

8 April 2019

stated in

SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IDA

endoplasmic reticulum membrane

determination method or standard

IC

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IEA

retrieved

8 April 2019

stated in

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IC

membrane

determination method or standard

IDA

IEA

2 references

retrieved

26 September 2017

stated in

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT9&geneProductId=UniProtKB:Q8TCT9

determination method or standard

IEA

retrieved

26 September 2017

stated in

Defining the membrane proteome of NK cells

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT9&geneProductId=UniProtKB:Q8TCT9

determination method or standard

IDA

integral component of cytoplasmic side of endoplasmic reticulum membrane

determination method or standard

IDA

1 reference

retrieved

26 September 2017

stated in

Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT9&geneProductId=UniProtKB:Q8TCT9

determination method or standard

IDA

plasma membrane

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IEA

Derlin-1 retrotranslocation complex

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IDA

integral component of lumenal side of endoplasmic reticulum membrane

determination method or standard

IDA

1 reference

retrieved

26 September 2017

stated in

Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT9&geneProductId=UniProtKB:Q8TCT9

determination method or standard

IDA

Golgi-associated vesicle membrane

determination method or standard

IBA

1 reference

retrieved

26 September 2017

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT9&geneProductId=UniProtKB:Q8TCT9

determination method or standard

IBA

lysosomal membrane

determination method or standard

IBA

1 reference

retrieved

26 September 2017

stated in

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT9&geneProductId=UniProtKB:Q8TCT9

determination method or standard

IBA

endoplasmic reticulum

determination method or standard

IDA

IEA

ISS

4 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

ISS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IEA

retrieved

8 April 2019

stated in

GOA

curator

Human Protein Atlas

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IDA

cell surface

determination method or standard

ISS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

ISS

membrane

determination method or standard

HDA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IEA

retrieved

8 April 2019

stated in

Defining the membrane proteome of NK cells

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

HDA

integral component of cytoplasmic side of endoplasmic reticulum membrane

determination method or standard

IBA

IDA

2 references

retrieved

8 April 2019

stated in

Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IBA

integral component of lumenal side of endoplasmic reticulum membrane

determination method or standard

IBA

IDA

2 references

retrieved

8 April 2019

stated in

Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IBA

biological process

membrane protein proteolysis

determination method or standard

IDA

1 reference

retrieved

26 September 2017

stated in

Impas 1 possesses endoproteolytic activity against multipass membrane protein substrate cleaving the presenilin 1 holoprotein

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TCT9&geneProductId=UniProtKB:Q8TCT9

determination method or standard

IDA

proteolysis

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IEA

membrane protein proteolysis involved in retrograde protein transport, ER to cytosol

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IMP

membrane protein intracellular domain proteolysis

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IMP

membrane protein ectodomain proteolysis

determination method or standard

IMP

1 reference

retrieved

8 April 2019

stated in

Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IMP

protein homotetramerization

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u

GOA

curator

Parkinsons Disease Gene Ontology Initiative

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

TAS

signal peptide processing

determination method or standard

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IBA

membrane protein proteolysis

determination method or standard

IBA

IDA

2 references

retrieved

8 April 2019

stated in

Impas 1 possesses endoproteolytic activity against multipass membrane protein substrate cleaving the presenilin 1 holoprotein

GOA

curator

UniProt

UniProt protein ID

Q8TCT9

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TCT9

determination method or standard

IBA

Identifiers

RefSeq protein ID

NP_110416

1 reference

stated in

NCBI Gene

retrieved

18 May 2018

Entrez Gene ID

81502

NP_848695

1 reference

stated in

NCBI Gene

retrieved

18 May 2018

Entrez Gene ID

81502

NP_848696

1 reference

stated in

NCBI Gene

retrieved

18 May 2018

Entrez Gene ID

81502

NP_848697

1 reference

stated in

NCBI Gene

retrieved

18 May 2018

Entrez Gene ID

81502

UniProt protein ID

Q8TCT9

1 reference

stated in

UniProt

retrieved

18 July 2018

UniProt protein ID

Q8TCT9

Ensembl protein ID

ENSP00000335294

1 reference

stated in

ensembl Release 93

Ensembl protein ID

ENSP00000335294

ENSP00000343032

1 reference

stated in

ensembl Release 93

Ensembl protein ID

ENSP00000343032

ENSP00000381237

1 reference

stated in

ensembl Release 93

Ensembl protein ID

ENSP00000381237

ENSP00000341347

1 reference

stated in

ensembl Release 93

Ensembl protein ID

ENSP00000341347

ENSP00000479020

1 reference

stated in

ensembl Release 93

Ensembl protein ID

ENSP00000479020

ENSP00000479443

1 reference

stated in

ensembl Release 93

Ensembl protein ID

ENSP00000479443

PDB structure ID

1INQ

1 reference

stated in

Swiss-Prot

UniProt

retrieved

10 November 2015

reference URL

http://www.uniprot.org/uniprot/Q9D8V0.txt?version=132

1JUF

1 reference

stated in

Swiss-Prot

UniProt

retrieved

10 November 2015

reference URL

http://www.uniprot.org/uniprot/Q9D8V0.txt?version=132

 

Sitelinks

Wikipedia(0 entries)

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Wikibooks(0 entries)

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Wikinews(0 entries)

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Wikiquote(0 entries)

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Wikisource(0 entries)

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Wikiversity(0 entries)

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Wikivoyage(0 entries)

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Wiktionary(0 entries)

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Multilingual sites(0 entries)

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Retrieved from "https://www.wikidata.org/w/index.php?title=Q21102548&oldid=2022920158"