Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3 (Q24306785)

From Wikidata

Jump to navigation Jump to search

scientific article

Language	Label	Description	Also known as
English	Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3	scientific article

Statements

scholarly article

0 references

Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3 (English)

0 references

1 reference

based on heuristic

inferred from title

Signal peptide peptidase like 2B

1 reference

GOA release 2020-03-11

Signal peptide peptidase like 3

1 reference

GOA release 2020-03-11

Histocompatibility minor 13

1 reference

GOA release 2020-03-11

protein homodimerization activity

1 reference

GOA release 2020-03-11

Histocompatibility (minor) 13

1 reference

GOA release 2020-03-11

Signal peptide peptidase-like 2

1 reference

GOA release 2020-03-11

Christian Haass

6

object named as

Christian Haass

author given names

Christian

author last names

Haass

1 reference

PubMed publication ID

9 December 2023

object named as

Peter Krawitz

1

author given names

Peter

author last names

Krawitz

1 reference

PubMed publication ID

9 December 2023

3

object named as

Regina Fluhrer

author given names

Regina

author last names

Fluhrer

1 reference

PubMed publication ID

9 December 2023

author name string

Christof Haffner

2

author given names

Christof

author last names

Haffner

1 reference

PubMed publication ID

9 December 2023

Harald Steiner

4

author given names

Harald

author last names

Steiner

1 reference

PubMed publication ID

9 December 2023

Bettina Schmid

5

author given names

Bettina

author last names

Schmid

1 reference

PubMed publication ID

9 December 2023

language of work or name

0 references

publication date

25 November 2005

0 references

Journal of Biological Chemistry

0 references

280

0 references

47

0 references

39515-23

0 references

Stages of embryonic development of the zebrafish

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulated intracellular ligand transport and proteolysis control EGF signal activation in Drosophila

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Large-scale mutagenesis in the zebrafish: in search of genes controlling development in a vertebrate.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Signal sequences: more than just greasy peptides

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Zebrafish (Danio rerio) presenilin promotes aberrant amyloid beta-peptide production and requires a critical aspartate residue for its function in amyloidogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Novel class of polytopic proteins with domains associated with putative protease activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Amyloid beta-peptide is produced by cultured cells during normal metabolism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

The role of presenilin cofactors in the gamma-secretase complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Reconstitution of gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Nicalin and its binding partner Nomo are novel Nodal signaling antagonists

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

A non-amyloidogenic function of BACE-2 in the secretory pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

The type 4 prepilin peptidases comprise a novel family of aspartic acid proteases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of distinct gamma-secretase complexes with different APH-1 variants

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Consensus analysis of signal peptide peptidase and homologous human aspartic proteases reveals opposite topology of catalytic domains compared with presenilins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of two lysosomal membrane glycoproteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of a novel family of presenilin homologues

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Intramembrane-cleaving aspartic proteases and disease: presenilins, signal peptide peptidase and their homologs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of signal peptide peptidase, a presenilin-type aspartic protease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Intramembrane proteolysis: theme and variations.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Increased extracellular amyloid deposition and neurodegeneration in human amyloid precursor protein transgenic mice deficient in receptor-associated protein.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M501645200

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q24306785&oldid=2026655259"