Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u (Q24304271)

GOA release 2020-03-11

Ring finger protein 139

1 reference

GOA release 2020-03-11

Derlin 1

1 reference

GOA release 2020-03-11

Dieter Langosch

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author name string

Chia-yi Chen

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Nicole S Malchus

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Beate Hehn

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Walter Stelzer

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Dönem Avci

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Marius K Lemberg

describes a project that uses

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language of work or name

English

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publication date

3 November 2014

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2492-506

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ImageJ

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4283407/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Defining human ERAD networks through an integrative mapping strategy

19 March 2017

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Protein disulphide isomerase is required for signal peptide peptidase-mediated protein degradation

19 March 2017

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The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER

19 March 2017

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The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER

19 March 2017

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RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene

19 March 2017

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Regulation of retrotranslocation by p97-associated deubiquitinating enzyme ataxin-3

19 March 2017

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pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response

19 March 2017

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Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane

19 March 2017

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A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol

19 March 2017

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A membrane protein required for dislocation of misfolded proteins from the ER

19 March 2017

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Intramembrane proteolysis promotes trafficking of hepatitis C virus core protein to lipid droplets

19 March 2017

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High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells

19 March 2017

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XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

19 March 2017

1 reference

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ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

19 March 2017

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Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors

19 March 2017

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Proteolysis inside the Membrane Is a Rate-Governed Reaction Not Driven by Substrate Affinity

19 March 2017

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A proteasomal ATPase contributes to dislocation of endoplasmic reticulum-associated degradation (ERAD) substrates.

19 March 2017

1 reference

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A versatile nanotrap for biochemical and functional studies with fluorescent fusion proteins

19 March 2017

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19 March 2017

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Signal peptide peptidase is required for dislocation from the endoplasmic reticulum

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283407

Proteasome inhibitors disrupt the unfolded protein response in myeloma cells

19 March 2017

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Requirements for signal peptide peptidase-catalyzed intramembrane proteolysis

19 March 2017

1 reference

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Identification of signal peptide peptidase, a presenilin-type aspartic protease

19 March 2017

1 reference

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Intramembrane proteolysis of signal peptides: an essential step in the generation of HLA-E epitopes

19 March 2017

1 reference

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Determination of the distance between the oligosaccharyltransferase active site and the endoplasmic reticulum membrane

19 March 2017

1 reference

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Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein response

19 March 2017

1 reference

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The unfolded protein response: from stress pathway to homeostatic regulation

19 March 2017

1 reference

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The role of autophagy in neurodegenerative disease

7 April 2017

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Cleavage by signal peptide peptidase is required for the degradation of selected tail-anchored proteins

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283407

A stalled retrotranslocation complex reveals physical linkage between substrate recognition and proteasomal degradation during ER-associated degradation

27 September 2017

1 reference

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Sampling the membrane: function of rhomboid-family proteins

27 September 2017

1 reference

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XBP-1u suppresses autophagy by promoting the degradation of FoxO1 in cancer cells

27 September 2017

1 reference

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B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPL2A.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283407

Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3).

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283407

The impact of the unfolded protein response on human disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283407

Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant α-1 antitrypsin from the endoplasmic reticulum

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283407

Three-dimensional structure of the signal peptide peptidase

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283407

Intramembrane Proteolysis in Regulated Protein Trafficking

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283407

Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283407

Translational Pausing Ensures Membrane Targeting and Cytoplasmic Splicing of XBP1u mRNA

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283407

Protein dislocation from the ER.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283407

Signal peptide peptidase (SPP) assembles with substrates and misfolded membrane proteins into distinct oligomeric complexes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283407

Sequence-specific intramembrane proteolysis: identification of a recognition motif in rhomboid substrates

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283407

Protein quality control as a strategy for cellular regulation: lessons from ubiquitin-mediated regulation of the sterol pathway

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283407

Intramembrane proteolysis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283407

pXBP1(U), a negative regulator of the unfolded protein response activator pXBP1(S), targets ATF6 but not ATF4 in proteasome-mediated degradation.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283407

Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283407

Signal peptide peptidase dependent cleavage of type II transmembrane substrates releases intracellular and extracellular signals

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283407

Distinct steps in dislocation of luminal endoplasmic reticulum-associated degradation substrates: roles of endoplamic reticulum-bound p97/Cdc48p and proteasome

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283407

Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283407

The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283407

The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283407

A misassembled transmembrane domain of a polytopic protein associates with signal peptide peptidase

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283407

Cotranslational targeting of XBP1 protein to the membrane promotes cytoplasmic splicing of its own mRNA.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283407

The fluorescence protease protection (FPP) assay to determine protein localization and membrane topology

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283407

Nicastrin functions as a gamma-secretase-substrate receptor

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4283407