Structural basis of kynurenine 3-monooxygenase inhibition (Q27677296)

GOA release 2020-03-11

NAD metabolic process

1 reference

Kynurenine 3-monooxygenase YBL098W

GOA release 2020-03-11

1 reference

ORCID Public Data File 2021

GOA release 2020-03-11

0 references

Derren J Heyes

1 reference

Nigel Scrutton

object named as

Nigel S Scrutton

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author name string

Marta Amaral

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Colin Levy

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Pierre Lafite

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Tiago F Outeiro

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Flaviano Giorgini

Kynurenines in the mammalian brain: when physiology meets pathology

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language of work or name

English

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publication date

18 April 2013

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published in

Nature

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volume

496

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issue

7445

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page(s)

382-5

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cites work

1 reference

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Structure of the PLP Degradative Enzyme 2-Methyl-3-hydroxypyridine-5-carboxylic Acid Oxygenase from Mesorhizobium loti MAFF303099 and Its Mechanistic Implications

20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease

20 March 2017

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Iterative model building, structure refinement and density modification with the PHENIX AutoBuild wizard

20 March 2017

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Actions of Xanthurenic acid, a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus

20 March 2017

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The kynurenine pathway modulates neurodegeneration in a Drosophila model of Huntington's disease

20 March 2017

1 reference

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Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS

20 March 2017

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Fast, efficient generation of high-quality atomic charges. AM1-BCC model: II. Parameterization and validation

20 March 2017

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Emerging concepts on inhibitors of indoleamine 2,3-dioxygenase in rheumatic diseases

7 April 2017

1 reference

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Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors

29 September 2017

1 reference

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Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration

29 September 2017

1 reference

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Indoleamine 2,3-dioxygenase, an emerging target for anti-cancer therapy

29 September 2017

1 reference

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Control of catalysis in flavin-dependent monooxygenases.

29 September 2017

1 reference

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Characterization of the kynurenine pathway in human neurons

29 September 2017

1 reference

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Flavoprotein monooxygenases, a diverse class of oxidative biocatalysts

29 September 2017

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Prolonged survival of a murine model of cerebral malaria by kynurenine pathway inhibition

29 September 2017

1 reference

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Expression of the kynurenine pathway enzymes in human microglia and macrophages

29 September 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736096

29 September 2017

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7 January 2021

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A rate-limiting conformational change of the flavin in p-hydroxybenzoate hydroxylase is necessary for ligand exchange and catalysis: studies with 8-mercapto- and 8-hydroxy-flavins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736096

Hydrogen peroxide-mediated neuronal cell death induced by an endogenous neurotoxin, 3-hydroxykynurenine

29 September 2017

1 reference

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The aryl hydrocarbon receptor in tumor immunity

29 September 2017

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Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736096

Blood?Brain Barrier Transport of Kynurenines: Implications for Brain Synthesis and Metabolism

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736096

Drosophila eye color mutants as therapeutic tools for Huntington disease.

2 June 2018

1 reference

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Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment.

27 November 2018

1 reference

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Perinatal kynurenine 3-hydroxylase inhibition in rodents: pathophysiological implications

27 November 2018

1 reference

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Endogenous kynurenate controls the vulnerability of striatal neurons to quinolinate: Implications for Huntington's disease

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736096

Effect of kynurenine 3-hydroxylase inhibition on the dyskinetic and antiparkinsonian responses to levodopa in Parkinsonian monkeys

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736096

Simple algorithm for a maximum-likelihood SAD function.

27 November 2018

1 reference

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Studies on the neuroprotective action of kynurenine mono-oxygenase inhibitors in post-ischemic brain damage.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736096

The kynurenine 3-hydroxylase inhibitor Ro 61-8048 improves dystonia in a genetic model of paroxysmal dyskinesia

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736096

Kynurenine hydroxylase inhibitors reduce ischemic brain damage: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(nitrophenyl)thiazol-2yl]-benzenesulfonamide (Ro 61-8048) in models of focal or global brain ischemia

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3736096

L-kynurenine 3-monooxygenase from mitochondrial outer membrane of pig liver: purification, some properties, and monoclonal antibodies directed to the enzyme

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23575632

12 December 2020

inferred from PubMed ID database lookup

Treating the Periphery to Ameliorate Neurodegenerative Diseases

1 reference

PubMed

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12 December 2020

inferred from PubMed ID database lookup

A Second Generation Force Field for the Simulation of Proteins, Nucleic Acids, and Organic Molecules

1 reference

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https://api.crossref.org/works/10.1038%2FNATURE12039

7 January 2021