Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment. (Q45307207)

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English	Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment.	scientific article

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29 December 2019

Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment (English)

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29 December 2019

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microglial inhibitor

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29 December 2019

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Flaviano Giorgini

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29 December 2019

Thomas Möller

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29 December 2019

Wanda Kwan

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29 December 2019

Daniel Zwilling

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29 December 2019

Jennifer L Wacker

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29 December 2019

Li-Chun L Tsai

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29 December 2019

Christine S Cheah

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29 December 2019

Robert Schwarcz

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29 December 2019

Paolo Guidetti

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29 December 2019

Paul J Muchowski

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13 December 2007

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29 December 2019

Journal of Biological Chemistry

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29 December 2019

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29 December 2019

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29 December 2019

7390-7400

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29 December 2019

Huntington's disease. Pathogenesis and management

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Evidence for degenerative and regenerative changes in neostriatal spiny neurons in Huntington's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Huntington's disease gene (IT15) is widely expressed in human and rat tissues

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Construction of human embryonic cDNA libraries: HD, PKD1 and BRCA1 are transcribed widely during embryogenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Cellular localization of the Huntington's disease protein and discrimination of the normal and mutated form

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Decreased neuronal and increased oligodendroglial densities in Huntington's disease caudate nucleus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Early and progressive accumulation of reactive microglia in the Huntington disease brain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Increased complement biosynthesis by microglia and complement activation on neurons in Huntington's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Ferritin accumulation in dystrophic microglia is an early event in the development of Huntington's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Behavioural abnormalities and selective neuronal loss in HD transgenic mice expressing mutated full-length HD cDNA.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Remote microglial activation in the quinolinic acid model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Microglia density decreases with age in a mouse model of Huntington's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Microglial activation in presymptomatic Huntington's disease gene carriers

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Microglial activation correlates with severity in Huntington disease: a clinical and PET study.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Manipulation of brain kynurenines: glial targets, neuronal effects, and clinical opportunities

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Neostriatal and cortical quinolinate levels are increased in early grade Huntington's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Transcriptional dysregulation in Huntington's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Transcriptional abnormalities in Huntington disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Huntington toxicity in yeast model depends on polyglutamine aggregation mediated by a prion-like protein Rnq1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Mutant huntingtin alters MAPK signaling pathways in PC12 and striatal cells: ERK1/2 protects against mutant huntingtin-associated toxicity.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Ume1p represses meiotic gene transcription in Saccharomyces cerevisiae through interaction with the histone deacetylase Rpd3p

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Genome-wide binding map of the histone deacetylase Rpd3 in yeast

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Human microglia convert l-tryptophan into the neurotoxin quinolinic acid

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Altered neurotransmitter receptor expression in transgenic mouse models of Huntington's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Genomewide studies of histone deacetylase function in yeast

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Alternate activation of two divergently transcribed mouse genes from a bidirectional promoter is linked to changes in histone modification

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Increased brain concentrations of a neurotoxin, 3-hydroxykynurenine, in Huntington's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Early kynurenergic impairment in Huntington's disease and in a transgenic animal model

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M708192200

21 January 2018

Onset and progression in inherited ALS determined by motor neurons and microglia

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21 January 2018

Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis

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21 January 2018

Bergmann glia expression of polyglutamine-expanded ataxin-7 produces neurodegeneration by impairing glutamate transport

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21 January 2018

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10.1074/JBC.M708192200

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18079112%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18079112%20AND%20SRC:MED&resulttype=core&format=json

29 December 2019

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