Kynurenine 3-monooxygenase (Q22677353)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15229

FAD/NAD(P)-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O15229

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

FAD-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

NAD(P)H oxidase H2O2-forming activity

3 references

16 July 2018

Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

16 July 2018

Structural Basis for Inhibitor-Induced Hydrogen Peroxide Production by Kynurenine 3-Monooxygenase

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

16 July 2018

Structural basis of kynurenine 3-monooxygenase inhibition

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

monooxygenase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

1 reference

8 April 2019

oxidoreductase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

1 reference

8 April 2019

kynurenine 3-monooxygenase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

10 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

16 July 2018

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

16 July 2018

Biochemistry and structural studies of kynurenine 3-monooxygenase reveal allosteric inhibition by Ro 61-8048.

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

16 July 2018

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

16 July 2018

Structural basis of kynurenine 3-monooxygenase inhibition

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

16 July 2018

Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

16 July 2018

Cloning and functional expression of human kynurenine 3‐monooxygenase

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

16 July 2018

Structural Basis for Inhibitor-Induced Hydrogen Peroxide Production by Kynurenine 3-Monooxygenase

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

flavin adenine dinucleotide binding

1 reference

24 April 2018

Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

kynurenine 3-monooxygenase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

11 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

8 April 2019

Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

8 April 2019

Structural Basis for Inhibitor-Induced Hydrogen Peroxide Production by Kynurenine 3-Monooxygenase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

8 April 2019

Structural basis of kynurenine 3-monooxygenase inhibition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

8 April 2019

Biochemistry and structural studies of kynurenine 3-monooxygenase reveal allosteric inhibition by Ro 61-8048.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

8 April 2019

Cloning and functional expression of human kynurenine 3‐monooxygenase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

8 April 2019

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

NAD(P)H oxidase H2O2-forming activity

Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

8 April 2019

Structural Basis for Inhibitor-Induced Hydrogen Peroxide Production by Kynurenine 3-Monooxygenase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

8 April 2019

Structural basis of kynurenine 3-monooxygenase inhibition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

flavin adenine dinucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

3 references

8 April 2019

8 April 2019

Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

integral component of membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

1 reference

8 April 2019

cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

1 reference

8 April 2019

TAS

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

1 reference

8 April 2019

mitochondrial outer membrane

Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase

3 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

16 July 2018

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

mitochondrial membranes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

1 reference

8 April 2019

extracellular space

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

mitochondrion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

mitochondrial outer membrane

Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

pyridine nucleotide biosynthetic process

biological process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

1 reference

8 April 2019

NAD biosynthetic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

1 reference

8 April 2019

response to salt stress

1 reference

8 April 2019

Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

secondary metabolite biosynthetic process

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

1 reference

16 July 2018

tryptophan catabolic process

TAS

response to lipopolysaccharide

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

cellular response to interleukin-1

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

L-kynurenine metabolic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

positive regulation of neuron death

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

positive regulation of glutamate secretion, neurotransmission

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

NAD metabolic process

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

8 April 2019

Structural Basis for Inhibitor-Induced Hydrogen Peroxide Production by Kynurenine 3-Monooxygenase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

8 April 2019

Structural basis of kynurenine 3-monooxygenase inhibition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

kynurenine metabolic process

5 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

16 July 2018

Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

16 July 2018

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

16 July 2018

Biochemistry and structural studies of kynurenine 3-monooxygenase reveal allosteric inhibition by Ro 61-8048.

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

16 July 2018

Structural Basis for Inhibitor-Induced Hydrogen Peroxide Production by Kynurenine 3-Monooxygenase

http://www.ebi.ac.uk/QuickGO/annotations?protein=O15229&geneProductId=UniProtKB:O15229

'de novo' NAD biosynthetic process from tryptophan

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

1 reference

8 April 2019

anthranilate metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

1 reference

8 April 2019

ageing

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

positive regulation of glutamate secretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

kynurenic acid biosynthetic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

kynurenine metabolic process

6 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

8 April 2019

Functional characterization and mechanism of action of recombinant human kynurenine 3-hydroxylase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

8 April 2019

Biochemistry and structural studies of kynurenine 3-monooxygenase reveal allosteric inhibition by Ro 61-8048.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

8 April 2019

Structural Basis for Inhibitor-Induced Hydrogen Peroxide Production by Kynurenine 3-Monooxygenase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

8 April 2019

Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

cellular response to lipopolysaccharide

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15229

1 reference

InterPro Release 71.0