Nature-Derived Peptides: A Growing Niche for GPCR Ligand Discovery (Q92905229)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30955896%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

title

Nature-Derived Peptides: A Growing Niche for GPCR Ligand Discovery (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30955896%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

Edin Muratspahić

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30955896%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

Michael Freissmuth

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30955896%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

Christian W Gruber

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30955896%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

publication date

5 April 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30955896%20AND%20SRC:MED&resulttype=core&format=json

Trends in Pharmacological Sciences

2 May 2020

published in

1 reference

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2 May 2020

volume

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2 May 2020

issue

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30955896%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

page(s)

309-326

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30955896%20AND%20SRC:MED&resulttype=core&format=json

GPCR drug discovery: integrating solution NMR data with crystal and cryo-EM structures

2 May 2020

cites work

1 reference

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Discovery, Synthesis, Pharmacological Profiling, and Biological Characterization of Brintonamides A-E, Novel Dual Protease and GPCR Modulators from a Marine Cyanobacterium

11 February 2021

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Discovery of peptide probes to modulate oxytocin-type receptors of insects

11 February 2021

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Glucagon-like peptide 1 in health and disease

11 February 2021

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Beef Protein-Derived Peptides as Bitter Taste Receptor T2R4 Blockers

11 February 2021

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The polypharmacology of natural products.

11 February 2021

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Designing macrocyclic disulfide-rich peptides for biotechnological applications

11 February 2021

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Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex.

11 February 2021

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Cone Snails: A Big Store of Conotoxins for Novel Drug Discovery.

11 February 2021

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Alpha conotoxin-BuIA globular isomer is a competitive antagonist for oleoyl-L-alpha-lysophosphatidic acid binding to LPAR6; A molecular dynamics study

11 February 2021

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Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species

11 February 2021

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G-Protein Coupled Receptors Targeted by Analgesic Venom Peptides

11 February 2021

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The unique structural and functional features of CXCL12

11 February 2021

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Trends in GPCR drug discovery: new agents, targets and indications.

11 February 2021

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Cyclotides Isolated from an Ipecac Root Extract Antagonize the Corticotropin Releasing Factor Type 1 Receptor.

11 February 2021

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Ribosomally-synthesised cyclic peptides from plants as drug leads and pharmaceutical scaffolds

11 February 2021

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How Ligands Illuminate GPCR Molecular Pharmacology

11 February 2021

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The Current State of Peptide Drug Discovery: Back to the Future?

11 February 2021

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Therapeutic peptides: Historical perspectives, current development trends, and future directions

11 February 2021

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Bioactive Peptide Natural Products as Lead Structures for Medicinal Use.

11 February 2021

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Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease

11 February 2021

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Cyclotides: Overview and Biotechnological Applications

11 February 2021

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Analgesic conopeptides targeting G protein-coupled receptors reduce excitability of sensory neurons

11 February 2021

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Pharmacological screening technologies for venom peptide discovery

11 February 2021

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A fully automated flow-based approach for accelerated peptide synthesis

11 February 2021

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Cell-Penetrating Peptides: From Basic Research to Clinics

11 February 2021

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Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide.

11 February 2021

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Beyond the margins: real-time detection of cancer using targeted fluorophores

11 February 2021

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Genomic charting of ribosomally synthesized natural product chemical space facilitates targeted mining

11 February 2021

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Accurate de novo design of hyperstable constrained peptides

11 February 2021

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Peptide-drug conjugates as effective prodrug strategies for targeted delivery.

11 February 2021

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Discovery, structure, function, and applications of cyclotides: circular proteins from plants

11 February 2021

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Counting on natural products for drug design

11 February 2021

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Blood-brain barrier shuttle peptides: an emerging paradigm for brain delivery

11 February 2021

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New winds in GPCR-based drug discovery

11 February 2021

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δ-Ctenitoxin-Pn1a, a Peptide from Phoneutria nigriventer Spider Venom, Shows Antinociceptive Effect Involving Opioid and Cannabinoid Systems, in Rats

11 February 2021

1 reference

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Oral activity of a nature-derived cyclic peptide for the treatment of multiple sclerosis

11 February 2021

1 reference

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Proteolytic processing of human serum albumin generates EPI-X4, an endogenous antagonist of CXCR4.

11 February 2021

1 reference

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Conopeptide-Derived κ-Opioid Agonists (Conorphins): Potent, Selective, and Metabolic Stable Dynorphin A Mimetics with Antinociceptive Properties.

11 February 2021

1 reference

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Natural Products as Sources of New Drugs from 1981 to 2014.

11 February 2021

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Design of a MCoTI-Based Cyclotide with Angiotensin (1-7)-Like Activity.

11 February 2021

1 reference

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Endolides A and B, Vasopressin and Serotonin-Receptor Interacting N-Methylated Peptides from the Sponge-Derived Fungus Stachylidium sp.

11 February 2021

1 reference

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Autocrine selection of a GLP-1R G-protein biased agonist with potent antidiabetic effects

11 February 2021

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Conotoxins: Structure, Therapeutic Potential and Pharmacological Applications

11 February 2021

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Emerging Approaches to GPCR Ligand Screening for Drug Discovery

11 February 2021

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Peptidomics of Circular Cysteine-Rich Plant Peptides: Analysis of the Diversity of Cyclotides from Viola tricolor by Transcriptome and Proteome Mining

11 February 2021

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CXCL12/CXCR4: a symbiotic bridge linking cancer cells and their stromal neighbors in oncogenic communication networks

11 February 2021

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Discovery and characterization of an endogenous CXCR4 antagonist

11 February 2021

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An opioid-like system regulating feeding behavior in C. elegans.

11 February 2021

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The re-emergence of natural products for drug discovery in the genomics era.

11 February 2021

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Recognition of bacterial signal peptides by mammalian formyl peptide receptors: a new mechanism for sensing pathogens

11 February 2021

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Cone snail venomics: from novel biology to novel therapeutics

11 February 2021

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Strategic approaches to optimizing peptide ADME properties

11 February 2021

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Evidence for the endothelin system as an emerging therapeutic target for the treatment of chronic pain

11 February 2021

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Targeting chemokine receptor CXCR4 for treatment of HIV-1 infection, tumor progression, and metastasis

11 February 2021

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Discovery of modulators of HIV-1 infection from the human peptidome

11 February 2021

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Polypharmacology profiles and phylogenetic analysis of three-finger toxins from mamba venom: case of aminergic toxins

11 February 2021

1 reference

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Pathomechanisms: homeostatic chemokines in health, tissue regeneration, and progressive diseases

11 February 2021

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Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design

11 February 2021

1 reference

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Molecular grafting onto a stable framework yields novel cyclic peptides for the treatment of multiple sclerosis.

11 February 2021

1 reference

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Production of recombinant disulfide-rich venom peptides for structural and functional analysis via expression in the periplasm of E. coli.

11 February 2021

1 reference

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Identification, structural and pharmacological characterization of τ-CnVA, a conopeptide that selectively interacts with somatostatin sst3 receptor

11 February 2021

1 reference

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The future of peptide-based drugs

11 February 2021

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Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

11 February 2021

1 reference

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Design of a novel cyclotide-based CXCR4 antagonist with anti-human immunodeficiency virus (HIV)-1 activity

11 February 2021

1 reference

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Design, Synthesis, Structural and Functional Characterization of Novel Melanocortin Agonists Based on the Cyclotide Kalata B1

11 February 2021

1 reference

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Effects of ρ-Da1a a peptidic α(1) (A) -adrenoceptor antagonist in human isolated prostatic adenoma and anaesthetized rats

11 February 2021

1 reference

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BmK-YA, an enkephalin-like peptide in scorpion venom

11 February 2021

1 reference

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Orally active peptidic bradykinin B1 receptor antagonists engineered from a cyclotide scaffold for inflammatory pain treatment

11 February 2021

1 reference

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Alpha-cobratoxin inhibits T-type calcium currents through muscarinic M4 receptor and Gο-protein βγ subunits-dependent protein kinase A pathway in dorsal root ganglion neurons.

11 February 2021

1 reference

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Characterization of a new muscarinic toxin from the venom of the Brazilian coral snake Micrurus lemniscatus in rat hippocampus

11 February 2021

1 reference

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11 February 2021

1 reference

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β‐Lactotensin derived from bovine β‐lactoglobulin exhibits anxiolytic‐like activity as an agonist for neurotensin NTS2 receptor via activation of dopamine D1 receptor in mice

11 February 2021

1 reference

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Pharmacological and structural characterization of long-sarafotoxins, a new family of endothelin-like peptides: Role of the C-terminus extension

11 February 2021

1 reference

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Adrenoceptor activity of muscarinic toxins identified from mamba venoms.

11 February 2021

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Selective targeting of G-protein-coupled receptor subtypes with venom peptides.

11 February 2021

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The snake venom peptide Bj-PRO-7a is a M1 muscarinic acetylcholine receptor agonist

11 February 2021

1 reference

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Ligand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptors

11 February 2021

1 reference

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Automated Fmoc-based solid-phase synthesis of peptide thioesters with self-purification effect and application in the construction of immobilized SH3 domains

11 February 2021

1 reference

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Identification of a novel snake peptide toxin displaying high affinity and antagonist behaviour for the α2-adrenoceptors.

11 February 2021

1 reference

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Structure-function studies of Tityus serrulatus Hypotensin-I (TsHpt-I): A new agonist of B(2) kinin receptor

11 February 2021

1 reference

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Isolation and pharmacological characterization of AdTx1, a natural peptide displaying specific insurmountable antagonism of the alpha1A-adrenoceptor.

11 February 2021

1 reference

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Apamin reduces neuromuscular transmission by activating inhibitory muscarinic M(2) receptors on motor nerve terminals

11 February 2021

1 reference

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Weak toxin WTX from Naja kaouthia cobra venom interacts with both nicotinic and muscarinic acetylcholine receptors

11 February 2021

1 reference

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Muscarinic toxins: tools for the study of the pharmacological and functional properties of muscarinic receptors

11 February 2021

1 reference

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Crotalphine, a novel potent analgesic peptide from the venom of the South American rattlesnake Crotalus durissus terrificus

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptides

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

Polydiscamides B-D from a marine sponge Ircinia sp. as potent human sensory neuron-specific G protein coupled receptor agonists

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

Helokinestatin: a new bradykinin B2 receptor antagonist decapeptide from lizard venom

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

Soymorphins, novel mu opioid peptides derived from soy beta-conglycinin beta-subunit, have anxiolytic activities

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

Beta-cardiotoxin: a new three-finger toxin from Ophiophagus hannah (king cobra) venom with beta-blocker activity.

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

Inhibition of acute nociceptive responses in rats after i.c.v. injection of Thr6-bradykinin, isolated from the venom of the social wasp, Polybia occidentalis

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

The immunosuppressant cyclosporin A antagonizes human formyl peptide receptor through inhibition of cognate ligand binding

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

AMD3100 mobilizes hematopoietic stem cells with long-term repopulating capacity in nonhuman primates.

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

Discovery of structurally diverse natural product antagonists of chemokine receptor CXCR3.

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

Solution structure of gamma-bungarotoxin: the functional significance of amino acid residues flanking the RGD motif in integrin binding

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

Subtype-selective noncompetitive or competitive inhibition of human alpha1-adrenergic receptors by rho-TIA.

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

Action of the muscarinic toxin MT7 on agonist-bound muscarinic M1 receptors

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

Kinestatin: a novel bradykinin B2 receptor antagonist peptide from the skin secretion of the Chinese toad, Bombina maxima

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

CJ-15,208, a novel kappa opioid receptor antagonist from a fungus, Ctenomyces serratus ATCC15502.

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

Muscarinic toxin-like proteins from Taiwan banded krait (Bungarus multicinctus) venom: purification, characterization and gene organization

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

Seven-transmembrane receptors

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

Rubiscolin, a delta selective opioid peptide derived from plant Rubisco

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

A family of depsi-peptide fungal metabolites, as selective and competitive human tachykinin receptor (NK2) antagonists: fermentation, isolation, physico-chemical properties, and biological activity

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

Muscarinic toxin-like proteins from cobra venom

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

Contulakin-G, an O-glycosylated invertebrate neurotensin

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

Isolation and biochemical characterization of a Ca2+-independent alpha-latrotoxin-binding protein

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled Receptor

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

RES-701-2, -3 and -4, novel and selective endothelin type B receptor antagonists produced by Streptomyces sp. I. Taxonomy of producing strains, fermentation, isolation, and biochemical properties.

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

Muscarinic toxins from the black mamba Dendroaspis polylepis

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

Bibrotoxin, a novel member of the endothelin/sarafotoxin peptide family, from the venom of the burrowing asp Atractaspis bibroni.

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

A brief history of opiates, opioid peptides, and opioid receptors

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

Cyclosporin H is a potent and selective formyl peptide receptor antagonist. Comparison with N-t-butoxycarbonyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L- leucyl-L-phenylalanine and cyclosporins A, B, C, D, and E

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

Cyclopsychotride A, a biologically active, 31-residue cyclic peptide isolated from Psychotria longipes

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

Opioid receptor binding profile of selected dermorphin-like peptides

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

Deltorphins: a family of naturally occurring peptides with high affinity and selectivity for delta opioid binding sites

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

An endothelin receptor (ETA) antagonist isolated from Streptomyces misakiensis

11 February 2021

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6624132

10.1016/J.TIPS.2019.03.004

11 February 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30955896%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30955896%20AND%20SRC:MED&resulttype=core&format=json

2 May 2020

PubMed publication ID

30955896

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30955896%20AND%20SRC:MED&resulttype=core&format=json