Cone snail venomics: from novel biology to novel therapeutics (Q35432836)

8 August 2017

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title

Cone snail venomics: from novel biology to novel therapeutics (English)

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8 August 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25406006%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

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9 June 2020

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9 June 2020

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9 June 2020

author name string

Jutty Rajan Prashanth

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25406006%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Andreas Brust

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9 June 2020

language of work or name

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1 October 2014

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Future Medicinal Chemistry

8 August 2017

published in

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9 June 2020

volume

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9 June 2020

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9 June 2020

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1659-1675

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Diagnosing the decline in pharmaceutical R&D efficiency

9 June 2020

cites work

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Lessons from 60 years of pharmaceutical innovation

21 January 2018

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The evolving role of natural products in drug discovery

21 January 2018

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Conus venom peptide pharmacology

21 January 2018

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Therapeutic potential of venom peptides

21 January 2018

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Venoms as a platform for human drugs: translating toxins into therapeutics

21 January 2018

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History of the design of captopril and related inhibitors of angiotensin converting enzyme

21 January 2018

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Drug development from marine natural products

21 January 2018

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Conus venoms: a rich source of novel ion channel-targeted peptides

21 January 2018

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Discovery, synthesis, and structure-activity relationships of conotoxins.

21 January 2018

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Therapeutic potential of cone snail venom peptides (conopeptides).

21 January 2018

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Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom

21 January 2018

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A novel Conus snail polypeptide causes excitotoxicity by blocking desensitization of AMPA receptors

21 January 2018

1 reference

Conantokin-G: a novel peptide antagonist to the N-methyl-D-aspartic acid (NMDA) receptor

21 January 2018

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The cystine knot motif in toxins and implications for drug design.

21 January 2018

1 reference

Conotoxins targeting nicotinic acetylcholine receptors: an overview

21 January 2018

1 reference

The synthesis, structural characterization, and receptor specificity of the alpha-conotoxin Vc1.1.

21 January 2018

1 reference

Isolation and structure-activity of mu-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels

21 January 2018

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muO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits

21 January 2018

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Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptides

21 January 2018

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Complex cocktails: the evolutionary novelty of venoms

21 January 2018

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Conotoxins, in retrospect

21 January 2018

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Towards an integrated venomics approach for accelerated conopeptide discovery

21 January 2018

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Venomics: a new paradigm for natural products-based drug discovery.

21 January 2018

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Transcriptomic messiness in the venom duct of Conus miles contributes to conotoxin diversity

21 January 2018

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MrIC, a novel α-conotoxin agonist in the presence of PNU at endogenous α7 nicotinic acetylcholine receptors

21 January 2018

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The future of peptide-based drugs

21 January 2018

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Future directions for peptide therapeutics development

21 January 2018

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Synthetic therapeutic peptides: science and market

21 January 2018

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21 January 2018

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The medicinal chemistry of peptides

21 January 2018

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Multifaceted roles of disulfide bonds. Peptides as therapeutics.

21 January 2018

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Strategies to deliver peptide drugs to the brain

21 January 2018

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Cysteine-rich mini-proteins in human biology.

21 January 2018

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Therapeutic potential of conopeptides

21 January 2018

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Recent progress towards pharmaceutical applications of disulfide-rich cyclic peptides

21 January 2018

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Cyclotides as a basis for drug design

21 January 2018

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New modalities in conformationally constrained peptides for potency, selectivity and cell permeation

21 January 2018

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Flexible or fixed: a comparative review of linear and cyclic cancer-targeting peptides.

21 January 2018

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Cyclization of conotoxins to improve their biopharmaceutical properties.

21 January 2018

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Cyclisation increases the stability of the sea anemone peptide APETx2 but decreases its activity at acid-sensing ion channel 3

21 January 2018

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Peptides and proteins as a continuing exciting source of inspiration for peptidomimetics

21 January 2018

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Modulating oxytocin activity and plasma stability by disulfide bond engineering

21 January 2018

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Cyclization of peptides by using selenolanthionine bridges.

21 January 2018

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Structure and activity of (2,8)-dicarba-(3,12)-cystino alpha-ImI, an alpha-conotoxin containing a nonreducible cystine analogue

21 January 2018

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Disulfide-Depleted Selenoconopeptides: a Minimalist Strategy to Oxidative Folding of Cysteine-Rich Peptides

21 January 2018

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Solving the alpha-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antagonists.

21 January 2018

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Disulfide bonds, their stereospecific environment and conservation in protein structures

21 January 2018

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Kinetic and thermodynamic aspects of cellular thiol-disulfide redox regulation

21 January 2018

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Getting in shape: controlling peptide bioactivity and bioavailability using conformational constraints

21 January 2018

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Chemical modifications designed to improve peptide stability: incorporation of non-natural amino acids, pseudo-peptide bonds, and cyclization

21 January 2018

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The practice of ring constraint in peptidomimetics using bicyclic and polycyclic amino acids

21 January 2018

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N-methylation of peptides: a new perspective in medicinal chemistry

21 January 2018

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Peptide and peptoid foldamers in medicinal chemistry

21 January 2018

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Peptoid polymers: a highly designable bioinspired material

21 January 2018

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Exploration of backbone space in foldamers containing alpha- and beta-amino acid residues: developing protease-resistant oligomers that bind tightly to the BH3-recognition cleft of Bcl-xL.

21 January 2018

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Design and Development of Peptides and Peptide Mimetics as Antagonists for Therapeutic Intervention

21 January 2018

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Peptidomimetics and peptide backbone modifications

21 January 2018

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Drug carriers for the delivery of therapeutic peptides.

21 January 2018

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Nanoparticles for oral delivery: targeted nanoparticles with peptidic ligands for oral protein delivery

21 January 2018

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Injectable implants for the sustained release of protein and peptide drugs.

21 January 2018

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Peptides and peptide conjugates: therapeutics on the upward path

21 January 2018

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Postformulation peptide drug loading of nanostructures

21 January 2018

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Oral delivery of peptides and proteins using lipid-based drug delivery systems

21 January 2018

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Oral absorption and in vivo biodistribution of alpha-conotoxin MII and a lipidic analogue

21 January 2018

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PEGylation: an approach for drug delivery. A review

21 January 2018

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Controlled systemic release of therapeutic peptides from PEGylated prodrugs by serum proteases

21 January 2018

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chi-Conopeptide pharmacophore development: toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain

21 January 2018

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Discovery of Modulators of Protein-Protein Interactions: Current Approaches and Limitations

21 January 2018

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Conformational constraints: nonpeptide beta-turn mimics

21 January 2018

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Peptidomimetics, a synthetic tool of drug discovery

21 January 2018

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Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structure.

21 January 2018

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Diversity of Conus neuropeptides

21 January 2018

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Conus ventricosus venom peptides profiling by HPLC-MS: a new insight in the intraspecific variation.

21 January 2018

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Intraspecific variation in the venom of the vermivorous cone snail Conus vexillum.

21 January 2018

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Comparative proteomic study of the venom of the piscivorous cone snail Conus consors

21 January 2018

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Intraspecific variation of venom injected by fish-hunting Conus snails

21 January 2018

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A New Family of Conus Peptides Targeted to the Nicotinic Acetylcholine Receptor

21 January 2018

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Peptide neurotoxins from fish-hunting cone snails

21 January 2018

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Precursor structure of omega-conotoxin GVIA determined from a cDNA clone

21 January 2018

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A new family of conotoxins that blocks voltage-gated sodium channels

21 January 2018

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Evolutionary diversification of multigene families: allelic selection of toxins in predatory cone snails

21 January 2018

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Alpha-conopeptides specifically expressed in the salivary gland of Conus pulicarius

21 January 2018

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Diversity and evolution of conotoxins based on gene expression profiling of Conus litteratus

21 January 2018

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Analysis of expressed sequence tags from the venom ducts of Conus striatus: focusing on the expression profile of conotoxins

21 January 2018

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High-resolution picture of a venom gland transcriptome: case study with the marine snail Conus consors

21 January 2018

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Next-generation DNA sequencing

21 January 2018

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Characterization of the Conus bullatus genome and its venom-duct transcriptome

21 January 2018

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Novel venom peptides from the cone snail Conus pulicarius discovered through next-generation sequencing of its venom duct transcriptome

21 January 2018

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Elucidation of the molecular envenomation strategy of the cone snail Conus geographus through transcriptome sequencing of its venom duct

21 January 2018

1 reference

Diversity of conotoxin gene superfamilies in the venomous snail, Conus victoriae

21 January 2018

1 reference

ConoDictor: a tool for prediction of conopeptide superfamilies

21 January 2018

1 reference

Systematic interrogation of the Conus marmoreus venom duct transcriptome with ConoSorter reveals 158 novel conotoxins and 13 new gene superfamilies

21 January 2018

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Combined proteomic and transcriptomic interrogation of the venom gland of Conus geographus uncovers novel components and functional compartmentalization

21 January 2018

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Messy biology and the origins of evolutionary innovations

21 January 2018

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Isolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequence

21 January 2018

1 reference

Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter

21 January 2018

1 reference

A novel alpha-conotoxin identified by gene sequencing is active in suppressing the vascular response to selective stimulation of sensory nerves in vivo.

21 January 2018

1 reference

Characterization of endogenous calcium responses in neuronal cell lines

21 January 2018

1 reference

Isolation and characterization of a novel conus peptide with apparent antinociceptive activity

21 January 2018

1 reference

lambda-conotoxins, a new family of conotoxins with unique disulfide pattern and protein folding. Isolation and characterization from the venom of Conus marmoreus

21 January 2018

1 reference

Current perspectives of the roles of the central norepinephrine system in anxiety and depression

21 January 2018

1 reference

Discovery and development of the χ-conopeptide class of analgesic peptides

21 January 2018

1 reference

Anti-allodynic efficacy of the chi-conopeptide, Xen2174, in rats with neuropathic pain

21 January 2018

1 reference

Designing peptide receptor agonists and antagonists

21 January 2018

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Inhibition of the norepinephrine transporter by the venom peptide chi-MrIA. Site of action, Na+ dependence, and structure-activity relationship

21 January 2018

1 reference

Solution structure of chi-conopeptide MrIA, a modulator of the human norepinephrine transporter

21 January 2018

1 reference

High-throughput synthesis of conopeptides: a safety-catch linker approach enabling disulfide formation in 96-well format

21 January 2018

1 reference

High-throughput synthesis of peptide α-thioesters: a safety catch linker approach enabling parallel hydrogen fluoride cleavage

21 January 2018

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Total chemical synthesis of proteins

21 January 2018

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The oyster genome reveals stress adaptation and complexity of shell formation

21 January 2018

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Soluble expression, purification and functional identification of a disulfide-rich conotoxin derived from Conus litteratus

21 January 2018

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Sequencing technologies - the next generation

21 January 2018

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Improving the Stability of α-Conotoxin AuIB Through N-to-C Cyclization: The Effect of Linker Length on Stability and Activity at Nicotinic Acetylcholine Receptors

21 January 2018

1 reference

Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain

21 January 2018

1 reference

Dramatic intraspecimen variations within the injected venom of Conus consors: An unsuspected contribution to venom diversity

21 January 2018

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Strategy for rapid immobilization of prey by a fish-hunting marine snail

21 January 2018

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