Understanding Obesity as a Risk Factor for Uterine Tumors Using Drosophila (Q90103124)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31520353%20AND%20SRC:MED&resulttype=core&format=json

11 April 2020

review article

1 reference

title

Understanding Obesity as a Risk Factor for Uterine Tumors Using Drosophila (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31520353%20AND%20SRC:MED&resulttype=core&format=json

11 April 2020

Xiao Li

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31520353%20AND%20SRC:MED&resulttype=core&format=json

11 April 2020

Mengmeng Liu

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31520353%20AND%20SRC:MED&resulttype=core&format=json

11 April 2020

Jun-Yuan Ji

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31520353%20AND%20SRC:MED&resulttype=core&format=json

11 April 2020

publication date

1 January 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31520353%20AND%20SRC:MED&resulttype=core&format=json

Advances in Experimental Medicine and Biology

11 April 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31520353%20AND%20SRC:MED&resulttype=core&format=json

11 April 2020

volume

1167

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31520353%20AND%20SRC:MED&resulttype=core&format=json

11 April 2020

page(s)

129-155

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31520353%20AND%20SRC:MED&resulttype=core&format=json

CDK8 maintains tumor dedifferentiation and embryonic stem cell pluripotency.

11 April 2020

cites work

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Expanded Somatic Mutation Spectrum of MED12 Gene in Uterine Leiomyomas of Saudi Arabian Women

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

TFIIH is negatively regulated by cdk8-containing mediator complexes

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Mad linker phosphorylations control the intensity and range of the BMP-activity gradient in developing Drosophila tissues

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

The Mediator complex: a central integrator of transcription

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Neurodegenerative disease and obesity: what is the role of weight loss and bariatric interventions?

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Genetic Interactions in Cancer Progression and Treatment

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

A Kinase-Independent Role for Cyclin-Dependent Kinase 19 in p53 Response.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Regulation of mTORC1 by amino acids

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Human cyclin C protein is stabilized by its associated kinase cdk8, independently of its catalytic activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Role of the mediator complex in nuclear hormone receptor signaling.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Molecular Genetics of Endometrial Carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

MED12 and HMGA2 mutations: two independent genetic events in uterine leiomyoma and leiomyosarcoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5·24 million UK adults

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Body size in relation to cancer of the uterine corpus in 1 million Norwegian women

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Medical Consequences of Obesity

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Recurrent chromosomal aberrations in intravenous leiomyomatosis of the uterus: high-resolution array comparative genomic hybridization study.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

TCFs and Wnt/β-catenin signaling: more than one way to throw the switch

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Expressions and clinical significance of COX-2, VEGF-C, and EFGR in endometrial carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Integrated genomic characterization of endometrial carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

CDK8/19 Mediator kinases potentiate induction of transcription by NFκB.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Obesity and Cancer: Evidence, Impact, and Future Directions

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Function and regulation of the Mediator complex

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Inhibition of tumor cell proliferation in human uterine leiomyomas by vitamin D via Wnt/β-catenin pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

MED12 and uterine smooth muscle oncogenesis: State of the art and perspectives

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

CDK8: a new breast cancer target

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Molecular and Functions of the CDK8 and CDK19 Kinase Modules

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Contextual determinants of TGFβ action in development, immunity and cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Mediator complex subunit 12 exon 2 mutation analysis in different subtypes of smooth muscle tumors confirms genetic heterogeneity

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

SREBPs in Lipid Metabolism, Insulin Signaling, and Beyond.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Transcriptional regulation of metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Missense mutations in exon 2 of the MED12 gene are involved in IGF-2 overexpression in uterine leiomyoma.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

CDK8 is a stimulus-specific positive coregulator of p53 target genes

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

The regulation of E2F by pRB-family proteins

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

How flies get their size: genetics meets physiology

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Endometrial Carcinoma: Specific Targeted Pathways.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Regulatory functions of the Mediator kinases CDK8 and CDK19

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Epidemiology of Endometrial Carcinoma: Etiologic Importance of Hormonal and Metabolic Influences

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC).

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Threonine affects intestinal function, protein synthesis and gene expression of TOR in Jian carp (Cyprinus carpio var. Jian).

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

HMGA2 and MED12 alterations frequently co-occur in uterine leiomyomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Amino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TOR

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

CDK8 Mediates the Dietary Effects on Developmental Transition in Drosophila

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Conditional abrogation of transforming growth factor-β receptor 1 in PTEN-inactivated endometrium promotes endometrial cancer progression in mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Genetic analysis of insulin signaling in Drosophila

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Impact of the obesity epidemic on cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Inflammatory Mechanisms in Obesity

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Tumor-suppressive effects of CDK8 in endometrial cancer cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

A prospective evaluation of insulin and insulin-like growth factor-I as risk factors for endometrial cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Drosophila in cancer research: to boldly go where no one has gone before

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Novel MED12 gene somatic mutations in women from the Southern United States with symptomatic uterine fibroids.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Estrogen Hormone Biology.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Clinical, pathologic, cytogenetic, and molecular profiling in self-identified black women with uterine leiomyomata

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Somatic MED12 Nonsense Mutation Escapes mRNA Decay and Reveals a Motif Required for Nuclear Entry

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Multiple clinical characteristics separate MED12-mutation-positive and -negative uterine leiomyomas.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

MED12 mutation frequency in unselected sporadic uterine leiomyomas.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

The interplay between obesity and cancer: a fly view

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

A rare coincidence of different types of driver mutations among uterine leiomyomas (UL).

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

The Epidemiology of Obesity: A Big Picture

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Obesity and cancer: local and systemic mechanisms

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Proteomic profiling of human uterine fibroids reveals upregulation of the extracellular matrix protein periostin.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Mutational analysis of MED12 exon 2 in uterine leiomyoma and other common tumors

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Key roles for MED1 LxxLL motifs in pubertal mammary gland development and luminal-cell differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Activated mutant p110α causes endometrial carcinoma in the setting of biallelic Pten deletion

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Somatic MED12 mutations are associated with poor prognosis markers in chronic lymphocytic leukemia

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Mutations in Exon 1 highlight the role of MED12 in uterine leiomyomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

The histone variant macroH2A suppresses melanoma progression through regulation of CDK8

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

A component of the ARC/Mediator complex required for TGF beta/Nodal signalling

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Role of progesterone in endometrial cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Mediator is a transducer of Wnt/beta-catenin signaling.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Mediator and the mechanism of transcriptional activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Uterine double-conditional inactivation of and in mice causes endometrial dysregulation, infertility, and uterine cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Cyclin-dependent kinase 8 module expression profiling reveals requirement of mediator subunits 12 and 13 for transcription of Serpent-dependent innate immunity genes in Drosophila.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

L-leucine, L-methionine, and L-lysine are involved in the regulation of intermediary metabolism-related gene expression in rainbow trout hepatocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

An emerging role of mTOR in lipid biosynthesis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Body Fatness and Cancer--Viewpoint of the IARC Working Group.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Pathology of Endometrial Carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Drosophila Cdk8, a kinase partner of cyclin C that interacts with the large subunit of RNA polymerase II.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Heart- and muscle-derived signaling system dependent on MED13 and Wingless controls obesity in Drosophila

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Analysis of MED12 Mutation in Multiple Uterine Leiomyomas in South Korean patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Tumor-suppressive signaling in the uterus

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

MED12 is frequently mutated in ovarian and other adnexal leiomyomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Exploring chromosomal abnormalities and genetic changes in uterine smooth muscle tumors

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

The impact of BMI on subgroups of uterine cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Loss of tuberous sclerosis complex-2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Body mass index and cancer: results from the Northern Sweden Health and Disease Cohort

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Co-twin control and cohort analyses of body mass index and height in relation to breast, prostate, ovarian, corpus uteri, colon and rectal cancer among Swedish and Finnish twins

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Branched-chain amino acids in metabolic signalling and insulin resistance

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Exome Sequencing of Uterine Leiomyosarcomas Identifies Frequent Mutations in TP53, ATRX, and MED12.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

MED12 exon 2 mutations are common in uterine leiomyomas from South African patients.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Mutation analysis of components of the Mediator kinase module in MED12 mutation-negative uterine leiomyomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Characterization of MED12, HMGA2, and FH alterations reveals molecular variability in uterine smooth muscle tumors.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

MED12 mutations in uterine fibroids--their relationship to cytogenetic subgroups

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Prevalence of MED12 mutations in uterine and extrauterine smooth muscle tumours

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Cdk8 deletion in the Apc(Min) murine tumour model represses EZH2 activity and accelerates tumourigenesis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Whole exome sequencing in a random sample of North American women with leiomyomas identifies MED12 mutations in majority of uterine leiomyomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Integrated data analysis reveals uterine leiomyoma subtypes with distinct driver pathways and biomarkers

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Characterization of uterine leiomyomas by whole-genome sequencing.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Genomics of uterine leiomyomas: insights from high-throughput sequencing

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

MicroRNAs involved in the HMGA2 deregulation and its co-occurrence with MED12 mutation in uterine leiomyoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

p53 activates transcription by directing structural shifts in Mediator

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Med12 gain-of-function mutation causes leiomyomas and genomic instability.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Activin-like kinase 5 (ALK5) inactivation in the mouse uterus results in metastatic endometrial carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Endocrinology of uterine fibroids: steroid hormones, stem cells, and genetic contribution.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

MED12 exon 2 mutations in phyllodes tumors of the breast

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Chronic activation of mTOR complex 1 by branched chain amino acids and organ hypertrophy.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Frequency and Spectrum of MED12 Exon 2 Mutations in Multiple Versus Solitary Uterine Leiomyomas From Russian Patients.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Mediator Kinase Disruption in MED12-Mutant Uterine Fibroids From Hispanic Women of South Texas

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of Cyclin C-CDK8/19.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Extrauterine adenomyoma: a review of the literature

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Epidemiology and Risk Factors of Uterine Fibroids

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Mediator kinase inhibition further activates super-enhancer-associated genes in AML

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

MED12 alterations in both human benign and malignant uterine soft tissue tumors

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Cyclin-Dependent Kinase 8: A New Hope in Targeted Cancer Therapy?

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

The medical risks of obesity

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Driver and passenger mutations in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Drosophila in cancer research. An expanding role.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Distinct mTORC1 pathways for transcription and cleavage of SREBP-1c.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

TGF-beta family signal transduction in Drosophila development: from Mad to Smads.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

The Transactivation Domains of the p53 Protein

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Obesity and incidence of cancer: a large cohort study of over 145,000 adults in Austria

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

MED12 mutations in leiomyosarcoma and extrauterine leiomyoma.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

The SREBP pathway--insights from Insigs and insects

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Cancer incidence and mortality in relation to body mass index in the Million Women Study: cohort study

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Obesity and cancer risk: the role of the insulin-IGF axis

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Coordination of patterning and growth by the morphogen DPP.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Risk factors for uterine fibroids: reduced risk associated with oral contraceptives.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Drosophila cancer models.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

CDK8 kinase--An emerging target in targeted cancer therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Twenty-five years of mTOR: Uncovering the link from nutrients to growth.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

The study of MED12 gene mutations in uterine leiomyomas from Iranian patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Inflammatory mechanisms linking obesity and metabolic disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

The roles of mediator complex in cardiovascular diseases

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

MED12 exon 2 mutations in uterine and extrauterine smooth muscle tumors.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Drosophila still flying high in cancer research.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Cellular kinetics of MED12-mutant uterine leiomyoma growth and regression in vivo.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Type I and II endometrial cancers: have they different risk factors?

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Expanding roles for SREBP in metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Regulation and Metabolic Significance of Lipogenesis in Adipose Tissues

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

The Epidemiology and Genetics of Uterine Leiomyoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Uterine adenomyoma: a clinicopathologic review of 26 cases and a review of the literature

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

MED12 protein expression in breast fibroepithelial lesions: correlation with mutation status and oestrogen receptor expression.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Identification of genes affecting wing patterning through a loss-of-function mutagenesis screen and characterization of med15 function during wing development

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

A conserved Mediator-CDK8 kinase module association regulates Mediator-RNA polymerase II interaction

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Uterine leiomyoma-linked MED12 mutations disrupt mediator-associated CDK activity.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

TGF-β Family Signaling in Drosophila

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

The many faces and functions of β-catenin

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Characterization of estrogen receptors alpha and beta in uterine leiomyoma cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Estrogen-regulated transcription: Mammary gland and uterus

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Drosophila models for cancer research.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

High-resolution melting analysis of MED12 mutations in uterine leiomyomas in Chinese patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

The mediator complex in genomic and non-genomic signaling in cancer.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Serum levels of insulin-like growth factor-I, IGF-binding protein 1 and 3, and insulin and endometrial cancer risk

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Branched-chain amino acids in disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

MED12 mutations and NOTCH signalling in chronic lymphocytic leukaemia.

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Prevalence and clinical significance of mediator complex subunit 12 mutations in 362 Han Chinese samples with uterine leiomyoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

CDK8-Cyclin C Mediates Nutritional Regulation of Developmental Transitions through the Ecdysone Receptor in Drosophila

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Posttranslational Regulation of Smads

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Dysregulation of CDK8 and Cyclin C in tumorigenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Components of the transcriptional Mediator complex are required for asymmetric cell division in C. elegans

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

The Emerging Role of Branched-Chain Amino Acids in Insulin Resistance and Metabolism

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Activation of the TOR Signalling Pathway by Glutamine Regulates Insect Fecundity

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Molecular analyses of 6 different types of uterine smooth muscle tumors: Emphasis in atypical leiomyoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Novel metabolic and physiological functions of branched chain amino acids: a review

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

CDK8 regulates E2F1 transcriptional activity through S375 phosphorylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Obesity, inflammatory markers, and endometrial cancer risk: a prospective case-control study

31 March 2020

1 reference

https://api.crossref.org/works/10.1007%2F978-3-030-23629-8_8

Electrophoretic analysis of polypeptides of plasma membranes from bovine pituitary gland.

31 March 2020

1 reference

12 December 2020

Increased plasma levels of insulin-like growth factor 2 and insulin-like growth factor binding protein 3 are associated with endometrial cancer risk.

1 reference

12 December 2020

Use of mutation profiles to refine the classification of endometrial carcinomas.

1 reference

12 December 2020

Drosophila as a model for context-dependent tumorigenesis

1 reference

12 December 2020

Endometriosis, leiomyoma and adenomyosis: the risk of gynecologic malignancy

1 reference

12 December 2020

Involvement of Mediator complex in malignancy.

1 reference

12 December 2020

Mediator kinase module and human tumorigenesis

1 reference

12 December 2020

Somatic mutational analysis of MED12 exon 2 in uterine leiomyomas of Iranian women

1 reference

12 December 2020

CDK8 Expression in Extrauterine Leiomyosarcoma Correlates With Tumor Stage and Progression

1 reference

12 December 2020

Silencing Med12 Gene Reduces Proliferation of Human Leiomyoma Cells Mediated via Wnt/β-Catenin Signaling Pathway

1 reference

12 December 2020

MED12 is recurrently mutated in Middle Eastern colorectal cancer.

1 reference

12 December 2020

10.1007/978-3-030-23629-8_8

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31520353%20AND%20SRC:MED&resulttype=core&format=json

11 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31520353%20AND%20SRC:MED&resulttype=core&format=json