Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms. (Q53195350)

12 May 2018

title

Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms. (English)

1 reference

12 May 2018

1 reference

12 May 2018

Tapio Visakorpi

1 reference

12 May 2018

Markku Varjosalo

1 reference

12 May 2018

Mikko Turunen

0 references

Netta Mäkinen

0 references

Salla Keskitalo

0 references

Tuomas Heikkinen

0 references

Heli Nevanlinna

1 reference

12 May 2018

Jukka-Pekka Mecklin

1 reference

12 May 2018

Heikki Järvinen

1 reference

12 May 2018

author name string

Kati Kämpjärvi

1 reference

12 May 2018

Nam Hee Kim

1 reference

12 May 2018

Alison D Clark

1 reference

12 May 2018

Pernilla von Nandelstadh

1 reference

12 May 2018

Min Ju Park

1 reference

12 May 2018

Kati Kivinummi

1 reference

12 May 2018

Susanna Lintula

1 reference

12 May 2018

Kristina Hotakainen

1 reference

12 May 2018

Tom Böhling

1 reference

12 May 2018

Ralf Bützow

1 reference

12 May 2018

Jan Böhm

1 reference

12 May 2018

Mika Kontro

1 reference

12 May 2018

Jussi Taipale

1 reference

12 May 2018

Thomas G Boyer

1 reference

12 May 2018

Pia Vahteristo

1 reference

12 May 2018

publication date

18 September 2015

1 reference

12 May 2018

published in

The Prostate

1 reference

12 May 2018

volume

1 reference

12 May 2018

issue

1 reference

12 May 2018

page(s)

22-31

1 reference

12 May 2018

The human Mediator complex: a versatile, genome-wide regulator of transcription

cites work

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

Function and regulation of the Mediator complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

Origins and activity of the Mediator complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

CDK8: a positive regulator of transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

Mutations in Exon 1 highlight the role of MED12 in uterine leiomyomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

Characterization of uterine leiomyomas by whole-genome sequencing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

Uterine leiomyoma-linked MED12 mutations disrupt mediator-associated CDK activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

Mutational analysis of MED12 exon 2 in uterine leiomyoma and other common tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

MED12 alterations in both human benign and malignant uterine soft tissue tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

MED12 mutations in leiomyosarcoma and extrauterine leiomyoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

Somatic MED12 mutations are associated with poor prognosis markers in chronic lymphocytic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

Next-Gen Sequencing Exposes Frequent MED12 Mutations and Actionable Therapeutic Targets in Phyllodes Tumors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

The protein interaction landscape of the human CMGC kinase group

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

Mutations in MED12 cause X-linked Ohdo syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

Mediator is a transducer of Wnt/beta-catenin signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

Regulation of androgen receptor-dependent transcription by coactivator MED1 is mediated through a newly discovered noncanonical binding motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

A coregulatory role for the mediator complex in prostate cancer cell proliferation and gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

ERK and AKT signaling drive MED1 overexpression in prostate cancer in association with elevated proliferation and tumorigenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

MED15, encoding a subunit of the mediator complex, is overexpressed at high frequency in castration-resistant prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

MED12 overexpression is a frequent event in castration-resistant prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

Epithelial-mesenchymal transitions in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

TGFβ-induced invasion of prostate cancer cells is promoted by c-Jun-dependent transcriptional activation of Snail1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

Stromal TGF-β signaling induces AR activation in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

The mutational landscape of lethal castration-resistant prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

The mitochondrial and autosomal mutation landscapes of prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

Lack of evidence for frequent MED12 p.L1224F mutation in prostate tumours from Caucasian patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

COSMIC: exploring the world's knowledge of somatic mutations in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

Discovery and saturation analysis of cancer genes across 21 tumour types

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23092

21 January 2018

Identifiers

DOI

10.1002/PROS.23092

1 reference

12 May 2018

1 reference

12 May 2018