Molecular and Functions of the CDK8 and CDK19 Kinase Modules (Q61448703)

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English	Molecular and Functions of the CDK8 and CDK19 Kinase Modules	No description defined

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instance of

scholarly article

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title

Molecular and Functions of the CDK8 and CDK19 Kinase Modules (English)

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author name string

Marius Volker Dannappel

series ordinal

1

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Dhanya Sooraj

series ordinal

2

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Jia Jian Loh

series ordinal

3

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Ron Firestein

series ordinal

4

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language of work or name

English

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publication date

2018

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published in

Frontiers in Cell and Developmental Biology

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volume

6

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page(s)

171

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copyright license

Creative Commons Attribution 4.0 International

start time

14 January 2019

1 reference

stated in

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

A novel transcription factor reveals a functional link between the RNA polymerase II CTD and TFIID.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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inferred from PubMed ID database lookup

Identification of genes required for alpha 2 repression in Saccharomyces cerevisiae

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Cyclin-dependent protein kinase and cyclin homologs SSN3 and SSN8 contribute to transcriptional control in yeast

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Association of an activator with an RNA polymerase II holoenzyme

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12 December 2020

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A kinase-cyclin pair in the RNA polymerase II holoenzyme.

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12 December 2020

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The yeast UME5 gene regulates the stability of meiotic mRNAs in response to glucose

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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A multisubunit complex associated with the RNA polymerase II CTD and TATA-binding protein in yeast.

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12 December 2020

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RNA polymerase II transcription initiation: a structural view

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Srb/mediator proteins interact functionally and physically with transcriptional repressor Sfl1.

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12 December 2020

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Dissecting the regulatory circuitry of a eukaryotic genome

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Progression from colorectal adenoma to carcinoma is associated with non-random chromosomal gains as detected by comparative genomic hybridisation

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Requirement for beta-catenin in anterior-posterior axis formation in mice

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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A transcriptional autoregulatory loop for KIN28-CCL1 and SRB10-SRB11, each encoding RNA polymerase II CTD kinase-cyclin pair, stimulates the meiotic development of S. cerevisiae

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Drosophila homologues of the transcriptional coactivation complex subunits TRAP240 and TRAP230 are required for identical processes in eye-antennal disc development.

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Characterization of mediator complexes from HeLa cell nuclear extract

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Interaction of the Srb10 kinase with Sip4, a transcriptional activator of gluconeogenic genes in Saccharomyces cerevisiae

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Structure, function, and activator-induced conformations of the CRSP coactivator

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Saccharomyces cerevisiae C-type cyclin Ume3p/Srb11p is required for efficient induction and execution of meiotic development

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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The protein kinase complement of the human genome

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Two subunits of the Drosophila mediator complex act together to control cell affinity

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Mediator expression profiling epistasis reveals a signal transduction pathway with antagonistic submodules and highly specific downstream targets

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Mediator is a transducer of Wnt/beta-catenin signaling.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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The general transcription machinery and general cofactors

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Mediator modulates Gli3-dependent Sonic hedgehog signaling

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Distinct roles for Mediator Cdk8 module subunits in Drosophila development.

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Cdk8 is essential for preimplantation mouse development

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Histone deacetylase inhibitors: overview and perspectives

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex

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12 December 2020

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Human mediator kinase subunit CDK11 plays a negative role in viral activator VP16-dependent transcriptional regulation

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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The DNA-damage response in human biology and disease

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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CDK8 is a positive regulator of transcriptional elongation within the serum response network

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Med12 is essential for early mouse development and for canonical Wnt and Wnt/PCP signaling

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Control of the embryonic stem cell state

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Inflammation meets cancer, with NF-κB as the matchmaker

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Inhibiting eukaryotic transcription: Which compound to choose? How to evaluate its activity?

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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CDK8 maintains tumor dedifferentiation and embryonic stem cell pluripotency.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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A cardiac microRNA governs systemic energy homeostasis by regulation of MED13

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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BET domain co-regulators in obesity, inflammation and cancer

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities.

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Dosage changes of MED13L further delineate its role in congenital heart defects and intellectual disability.

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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A conserved Mediator-CDK8 kinase module association regulates Mediator-RNA polymerase II interaction

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Sox10 cooperates with the mediator subunit 12 during terminal differentiation of myelinating glia

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Mediator complex recruits epigenetic regulators via its two cyclin-dependent kinase subunits to repress transcription of immune response genes

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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The Mediator complex and transcription regulation

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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New and emerging HDAC inhibitors for cancer treatment

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Interferon-stimulated genes: a complex web of host defenses

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Further confirmation of the MED13L haploinsufficiency syndrome

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Subunit architecture and functional modular rearrangements of the transcriptional mediator complex

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12 December 2020

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The mechanisms behind the therapeutic activity of BET bromodomain inhibition

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12 December 2020

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Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress.

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12 December 2020

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Heart- and muscle-derived signaling system dependent on MED13 and Wingless controls obesity in Drosophila

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Cyclin-dependent kinases

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Cyclin C is a haploinsufficient tumour suppressor

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12 December 2020

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Fine-tuning of histone H3 Lys4 methylation during pseudohyphal differentiation by the CDK submodule of RNA polymerase II.

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Proteomics. Tissue-based map of the human proteome

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12 December 2020

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The Mediator complex: a central integrator of transcription

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Novel de novo heterozygous loss-of-function variants in MED13L and further delineation of the MED13L haploinsufficiency syndrome.

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12 December 2020

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Cdk8 deletion in the Apc(Min) murine tumour model represses EZH2 activity and accelerates tumourigenesis.

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12 December 2020

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Mediator kinase inhibition further activates super-enhancer-associated genes in AML

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12 December 2020

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Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Identification of Mediator Kinase Substrates in Human Cells using Cortistatin A and Quantitative Phosphoproteomics.

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12 December 2020

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MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis

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High-throughput discovery of novel developmental phenotypes

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12 December 2020

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Pan-Cancer Analysis of the Mediator Complex Transcriptome Identifies CDK19 and CDK8 as Therapeutic Targets in Advanced Prostate Cancer

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12 December 2020

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Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Mediator cyclin-dependent kinases upregulate transcription of inflammatory genes in cooperation with NF-κB and C/EBPβ on stimulation of Toll-like receptor 9.

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12 December 2020

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A Kinase-Independent Role for Cyclin-Dependent Kinase 19 in p53 Response.

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12 December 2020

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Hypoxia inducible factors in hepatocellular carcinoma

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12 December 2020

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A subcellular map of the human proteome

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12 December 2020

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A pathology atlas of the human cancer transcriptome

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12 December 2020

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CDK8/19 Mediator kinases potentiate induction of transcription by NFκB.

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12 December 2020

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CDK8 Kinase Activity Promotes Glycolysis.

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12 December 2020

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Mediator complex component MED13 regulates zygotic genome activation and is required for postimplantation development in the mouse.

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12 December 2020

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CDK8/19 inhibition induces premature G1/S transition and ATR-dependent cell death in prostate cancer cells.

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12 December 2020

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De novo mutations in MED13, a component of the Mediator complex, are associated with a novel neurodevelopmental disorder.

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https://pubmed.ncbi.nlm.nih.gov/30693281

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12 December 2020

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Identifiers

DOI

10.3389/FCELL.2018.00171

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PMC publication ID

6340071

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PubMed publication ID

30693281

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