Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids (Q89838002)

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scientific article published on 20 February 2020

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English	Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids	scientific article published on 20 February 2020

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Europe PubMed Central

PubMed publication ID

32086379

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32086379%20AND%20SRC:MED&resulttype=core&format=json

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8 April 2020

title

Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids (English)

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PubMed publication ID

32086379

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main subject

organoid

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author

Pierre Maisonneuve

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2

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PubMed publication ID

32086379

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8 April 2020

Manuel Kaulich

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5

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PubMed publication ID

32086379

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Igor Kurinov

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8

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PubMed publication ID

32086379

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Henner F Farin

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9

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PubMed publication ID

32086379

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author name string

Svenja Wiechmann

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1

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PubMed publication ID

32086379

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8 April 2020

Britta M Grebbin

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3

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PubMed publication ID

32086379

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8 April 2020

Meike Hoffmeister

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4

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PubMed publication ID

32086379

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Hans Clevers

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6

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32086379

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8 April 2020

Krishnaraj Rajalingam

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7

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PubMed publication ID

32086379

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8 April 2020

Frank Sicheri

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10

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PubMed publication ID

32086379

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8 April 2020

Andreas Ernst

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11

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PubMed publication ID

32086379

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language of work or name

English

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publication date

20 February 2020

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PubMed publication ID

32086379

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8 April 2020

number of pages

15

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published in

Journal of Biological Chemistry

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PubMed publication ID

32086379

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8 April 2020

volume

295

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PubMed publication ID

32086379

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8 April 2020

issue

14

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PubMed publication ID

32086379

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8 April 2020

page(s)

4526-4540

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Europe PubMed Central

PubMed publication ID

32086379

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8 April 2020

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ImageJ

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11 June 2022

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https://www.ebi.ac.uk/europepmc/webservices/rest/PMC7136003/fullTextXML

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cites work

Kinetics of interaction of nucleotides with nucleotide-free H-ras p21

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Rapid and efficient site-specific mutagenesis without phenotypic selection

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The 2.2 A crystal structure of the Ras-binding domain of the serine/threonine kinase c-Raf1 in complex with Rap1A and a GTP analogue

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cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway

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PubMed

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12 December 2020

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Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

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12 December 2020

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Isoform-specific localization of A-RAF in mitochondria

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Point mutants of c-raf-1 RBD with elevated binding to v-Ha-Ras

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PubMed

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Thermodynamics of Ras/effector and Cdc42/effector interactions probed by isothermal titration calorimetry

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Active Ras induces heterodimerization of cRaf and BRaf

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Stop and go extraction tips for matrix-assisted laser desorption/ionization, nanoelectrospray, and LC/MS sample pretreatment in proteomics

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A detailed thermodynamic analysis of ras/effector complex interfaces

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12 December 2020

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Refinement of macromolecular structures by the maximum-likelihood method

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PubMed

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12 December 2020

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Coot: model-building tools for molecular graphics

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PubMed

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Massive sequence perturbation of a small protein.

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12 December 2020

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Production and purification of lentiviral vectors

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In-gel digestion for mass spectrometric characterization of proteins and proteomes

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12 December 2020

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Tumour prevention by a single antibody domain targeting the interaction of signal transduction proteins with RAS

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Inference of macromolecular assemblies from crystalline state

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MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

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Phasercrystallographic software

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12 December 2020

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Improved binding of raf to Ras.GDP is correlated with biological activity

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XDS

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

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What makes Ras an efficient molecular switch: a computational, biophysical, and structural study of Ras-GDP interactions with mutants of Raf

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Molecular Genetics of Colorectal Cancer

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Andromeda: a peptide search engine integrated into the MaxQuant environment

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Overview of the CCP4 suite and current developments

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Mass spectrometry-based proteomics using Q Exactive, a high-performance benchtop quadrupole Orbitrap mass spectrometer.

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12 December 2020

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Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

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12 December 2020

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Controlled gene expression in primary Lgr5 organoid cultures

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12 December 2020

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A Strategy for Modulation of Enzymes in the Ubiquitin System

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12 December 2020

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A review of novel therapies for melanoma

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12 December 2020

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Accurate proteome-wide label-free quantification by delayed normalization and maximal peptide ratio extraction, termed MaxLFQ.

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Promises and pitfalls of intracellular delivery of proteins

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12 December 2020

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Drugging the undruggable RAS: Mission possible?

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12 December 2020

based on heuristic

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Allosteric effects of the oncogenic RasQ61L mutant on Raf-RBD

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12 December 2020

based on heuristic

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Prospective derivation of a living organoid biobank of colorectal cancer patients.

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12 December 2020

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Efficient Delivery of Structurally Diverse Protein Cargo into Mammalian Cells by a Bacterial Toxin.

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https://pubmed.ncbi.nlm.nih.gov/32086379

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12 December 2020

based on heuristic

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RAS/Effector Interactions from Structural and Biophysical Perspective

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12 December 2020

based on heuristic

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Discovery of a Direct Ras Inhibitor by Screening a Combinatorial Library of Cell-Permeable Bicyclic Peptides

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The Perseus computational platform for comprehensive analysis of (prote)omics data

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12 December 2020

based on heuristic

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Resistant mechanisms to BRAF inhibitors in melanoma

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12 December 2020

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Automated refinement of macromolecular structures at low resolution using prior information

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12 December 2020

based on heuristic

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Inhibition of RAS function through targeting an allosteric regulatory site.

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12 December 2020

based on heuristic

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The RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding Regions

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12 December 2020

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KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer

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12 December 2020

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Antibody targeting intracellular oncogenic Ras mutants exerts anti-tumour effects after systemic administration.

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12 December 2020

based on heuristic

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Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange.

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12 December 2020

based on heuristic

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An engineered protein antagonist of K-Ras/B-Raf interaction

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12 December 2020

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Site-specific inhibition of the small ubiquitin-like modifier (SUMO)-conjugating enzyme Ubc9 selectively impairs SUMO chain formation.

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12 December 2020

based on heuristic

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Exceptionally high-affinity Ras binders that remodel its effector domain.

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12 December 2020

based on heuristic

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A Raf-Competitive K-Ras Binder Can Fail to Functionally Antagonize Signaling

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12 December 2020

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The PRIDE database and related tools and resources in 2019: improving support for quantification data

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12 December 2020

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Targeting the α4-α5 dimerization interface of K-RAS inhibits tumor formation in vivo

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Towards the application of Tc toxins as a universal protein translocation system

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Identifiers

DOI

10.1074/JBC.RA119.011025

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Europe PubMed Central

PubMed publication ID

32086379

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32086379%20AND%20SRC:MED&resulttype=core&format=json

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8 April 2020

PMC publication ID

7136003

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PubMed publication ID

32086379

1 reference

stated in

Europe PubMed Central

PubMed publication ID

32086379

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:32086379%20AND%20SRC:MED&resulttype=core&format=json

retrieved

8 April 2020

 

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