Tumour prevention by a single antibody domain targeting the interaction of signal transduction proteins with RAS (Q27645826)

22 June 2017

title

Tumour prevention by a single antibody domain targeting the interaction of signal transduction proteins with RAS (English)

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22 June 2017

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22 June 2017

Terence H Rabbitts

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Tomoyuki Tanaka

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22 June 2017

language of work or name

English

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publication date

14 June 2007

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22 June 2017

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22 June 2017

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22 June 2017

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22 June 2017

page(s)

3250-3259

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Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

22 June 2017

cites work

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20 March 2017

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The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins

20 March 2017

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Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras

20 March 2017

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Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins

20 March 2017

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

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The CCP4 suite: programs for protein crystallography

20 March 2017

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The atomic structure of protein-protein recognition sites

20 March 2017

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Improved methods for building protein models in electron density maps and the location of errors in these models

20 March 2017

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The guanine nucleotide-binding switch in three dimensions

20 March 2017

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Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

20 March 2017

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Targeting RAS signalling pathways in cancer therapy

20 March 2017

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Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes

20 March 2017

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Isolation of a transforming sequence from a human bladder carcinoma cell line

20 March 2017

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Coordinating ERK/MAPK signalling through scaffolds and inhibitors

20 March 2017

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Recent advances with liposomes as pharmaceutical carriers

7 April 2017

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Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery

7 April 2017

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K-ras as a target for cancer therapy

29 September 2017

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Gene therapy: twenty-first century medicine

29 September 2017

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RalGDS is required for tumor formation in a model of skin carcinogenesis.

29 September 2017

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Single domain intracellular antibodies: a minimal fragment for direct in vivo selection of antigen-specific intrabodies

29 September 2017

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Intrabodies based on intracellular capture frameworks that bind the RAS protein with high affinity and impair oncogenic transformation

29 September 2017

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Intracellular antibody capture technology: application to selection of intracellular antibodies recognising the BCR-ABL oncogenic protein

29 September 2017

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Protein transduction technology

29 September 2017

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Blocking oncogenic Ras signaling for cancer therapy

29 September 2017

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The EGF receptor family as targets for cancer therapy

29 September 2017

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Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

29 September 2017

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Targeting rare populations of murine antigen-specific T lymphocytes by retroviral transduction for potential application in gene therapy for autoimmune disease

29 September 2017

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Selection of antibodies for intracellular function using a two-hybrid in vivo system

29 September 2017

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Essential role for oncogenic Ras in tumour maintenance

29 September 2017

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Loss of oncogenic ras expression does not correlate with loss of tumorigenicity in human cells

29 September 2017

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Evidence for proteasome dysfunction in cytotoxicity mediated by anti-Ras intracellular antibodies.

29 September 2017

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Biological properties of human c-Ha-ras1 genes mutated at codon 12.

2 June 2018

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Chromosomal translocation engineering to recapitulate primary events of human cancer.

2 June 2018

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The activation of RalGDS can be achieved independently of its Ras binding domain. Implications of an activation mechanism in Ras effector specificity and signal distribution

27 November 2018

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12 December 2020

Transient Kinetic Studies on the Interaction of Ras and the Ras-Binding Domain of c-Raf-1 Reveal Rapid Equilibration of the Complex†

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12 December 2020

Species- and cell type-specific requirements for cellular transformation

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12 December 2020

Re: Blocking Oncogenic Ras Signaling for Cancer Therapy

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12 December 2020

Intracellular Antibodies

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7601744

7 January 2021

inferred from DOI database lookup

AMoRe: an automated package for molecular replacement

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7601744

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/SJ.EMBOJ.7601744

1 reference

OpenCitations bibliographic resource ID

22 June 2017

1472320

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1472320

1 reference