The role of ubiquitin-specific peptidases in cancer progression (Q64288182)

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28 April 2020

review article

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29 October 2020

8 February 2021

The role of ubiquitin-specific peptidases in cancer progression (English)

1 reference

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28 April 2020

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29 October 2020

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8 February 2021

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28 April 2020

Ming-Jer Young

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28 April 2020

Kai-Cheng Hsu

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28 April 2020

Tony Eight Lin

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28 April 2020

Wen-Chang Chang

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28 April 2020

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English

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publication date

27 May 2019

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28 April 2020

29 October 2020

8 February 2021

Journal of Biomedical Science

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28 April 2020

29 October 2020

8 February 2021

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28 April 2020

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28 April 2020

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Creative Commons Attribution 4.0 International

28 April 2020

2 references

29 October 2020

Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade

8 February 2021

cites work

1 reference

12 December 2020

Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases

1 reference

12 December 2020

An azoospermic man with a de novo point mutation in the Y-chromosomal gene USP9Y

1 reference

12 December 2020

An abundance of X-linked genes expressed in spermatogonia

1 reference

12 December 2020

Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein

1 reference

12 December 2020

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

1 reference

12 December 2020

The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

1 reference

12 December 2020

Two isoforms of otubain 1 regulate T cell anergy via GRAIL

1 reference

12 December 2020

The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer

1 reference

12 December 2020

A dynamic role of HAUSP in the p53-Mdm2 pathway

1 reference

12 December 2020

APC/C and SCF: controlling each other and the cell cycle

1 reference

12 December 2020

Novel mutations in testis-specific ubiquitin protease 26 gene may cause male infertility and hypogonadism

1 reference

12 December 2020

A leukemia-enriched cDNA microarray platform identifies new transcripts with relevance to the biology of pediatric acute lymphoblastic leukemia.

1 reference

12 December 2020

Ubiquitylation and cell signaling

1 reference

12 December 2020

A genomic and functional inventory of deubiquitinating enzymes

1 reference

12 December 2020

A novel and cytogenetically cryptic t(7;21)(p22;q22) in acute myeloid leukemia results in fusion of RUNX1 with the ubiquitin-specific protease gene USP42.

1 reference

12 December 2020

Protein degradation by the ubiquitin-proteasome pathway in normal and disease states

1 reference

12 December 2020

A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response

1 reference

12 December 2020

FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP

1 reference

12 December 2020

Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis.

1 reference

12 December 2020

Activation of a novel Bcr/Abl destruction pathway by WP1130 induces apoptosis of chronic myelogenous leukemia cells

1 reference

12 December 2020

Ubiquitination regulates PTEN nuclear import and tumor suppression

1 reference

12 December 2020

2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K.

1 reference

12 December 2020

The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2

1 reference

12 December 2020

Ubp43 regulates BCR-ABL leukemogenesis via the type 1 interferon receptor signaling

1 reference

12 December 2020

Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities

1 reference

12 December 2020

Fbw7 and Usp28 regulate myc protein stability in response to DNA damage

1 reference

12 December 2020

Regulation of cell cycle progression and gene expression by H2A deubiquitination

1 reference

12 December 2020

Human USP3 is a chromatin modifier required for S phase progression and genome stability

1 reference

12 December 2020

Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD.

1 reference

12 December 2020

Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation

1 reference

12 December 2020

Regulation of mitochondrial morphology by USP30, a deubiquitinating enzyme present in the mitochondrial outer membrane

1 reference

12 December 2020

Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD.

1 reference

12 December 2020

USP22, an hSAGA subunit and potential cancer stem cell marker, reverses the polycomb-catalyzed ubiquitylation of histone H2A

1 reference

12 December 2020

The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response

1 reference

12 December 2020

The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network

1 reference

12 December 2020

Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes

1 reference

12 December 2020

USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1

1 reference

12 December 2020

Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53

1 reference

12 December 2020

FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination

1 reference

12 December 2020

Lysine 63-linked polyubiquitin chain may serve as a targeting signal for the 26S proteasome

1 reference

12 December 2020

Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2

1 reference

12 December 2020

CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes

1 reference

12 December 2020

The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization

1 reference

12 December 2020

The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates

1 reference

12 December 2020

Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes

1 reference

12 December 2020

Recognition and processing of ubiquitin-protein conjugates by the proteasome

1 reference

12 December 2020

Breaking the chains: structure and function of the deubiquitinases

1 reference

12 December 2020

Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells

1 reference

12 December 2020

MdmX is a substrate for the deubiquitinating enzyme USP2a

1 reference

12 December 2020

USP11 negatively regulates TNFalpha-induced NF-kappaB activation by targeting on IkappaBalpha.

1 reference

12 December 2020

Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1.

1 reference

12 December 2020

Suppression of cancer cell growth by promoting cyclin D1 degradation

1 reference

12 December 2020

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

1 reference

12 December 2020

Emerging roles of deubiquitinases in cancer-associated pathways

1 reference

12 December 2020

USP10 regulates p53 localization and stability by deubiquitinating p53

1 reference

12 December 2020

WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complex

1 reference

12 December 2020

Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes

1 reference

12 December 2020

Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A

1 reference

12 December 2020

Signaling to NF-kappaB: regulation by ubiquitination

1 reference

12 December 2020

Ubiquitin-specific protease 8 links the PTEN-Akt-AIP4 pathway to the control of FLIPS stability and TRAIL sensitivity in glioblastoma multiforme

1 reference

12 December 2020

The deubiquitinating enzyme USP26 is a regulator of androgen receptor signaling

1 reference

12 December 2020

USP32 is an active, membrane-bound ubiquitin protease overexpressed in breast cancers

1 reference

12 December 2020

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

1 reference

12 December 2020

The Deubiquitinating Enzyme USP8 Promotes Trafficking and Degradation of the Chemokine Receptor 4 at the Sorting Endosome

1 reference

12 December 2020

A screen for deubiquitinating enzymes involved in the G₂/M checkpoint identifies USP50 as a regulator of HSP90-dependent Wee1 stability.

1 reference

12 December 2020

Ubiquitin becomes ubiquitous in cancer: emerging roles of ubiquitin ligases and deubiquitinases in tumorigenesis and as therapeutic targets

1 reference

12 December 2020

Deubiquitinase inhibition by small-molecule WP1130 triggers aggresome formation and tumor cell apoptosis.

1 reference

12 December 2020

Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity

1 reference

12 December 2020

Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis

1 reference

12 December 2020

JTV1 co-activates FBP to induce USP29 transcription and stabilize p53 in response to oxidative stress

1 reference

12 December 2020

USP4 targets TAK1 to downregulate TNFα-induced NF-κB activation

1 reference

12 December 2020

USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase β

1 reference

12 December 2020

The ubiquitin-specific protease USP34 regulates axin stability and Wnt/β-catenin signaling

1 reference

12 December 2020

The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility

1 reference

12 December 2020

Disruption of the MDM2-p53 interaction strongly potentiates p53-dependent apoptosis in cisplatin-resistant human testicular carcinoma cells via the Fas/FasL pathway.

1 reference

12 December 2020

USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1

1 reference

12 December 2020

Ubiquitin-specific peptidase 20 targets TRAF6 and human T cell leukemia virus type 1 tax to negatively regulate NF-kappaB signaling

1 reference

12 December 2020

p53 regulation by ubiquitin

1 reference

12 December 2020

A novel small molecule deubiquitinase inhibitor blocks Jak2 signaling through Jak2 ubiquitination

1 reference

12 December 2020

USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma

1 reference

12 December 2020

USP22 acts as an oncogene by the activation of BMI-1-mediated INK4a/ARF pathway and Akt pathway

1 reference

12 December 2020

USP15 is a deubiquitylating enzyme for receptor-activated SMADs

1 reference

12 December 2020

Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13

1 reference

12 December 2020

PTBP1-dependent regulation of USP5 alternative RNA splicing plays a role in glioblastoma tumorigenesis

1 reference

12 December 2020

Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNFα-induced cancer cell migration.

1 reference

12 December 2020

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

1 reference

12 December 2020

Atypical mechanism of NF-κB activation by TRE17/ubiquitin-specific protease 6 (USP6) oncogene and its requirement in tumorigenesis

1 reference

12 December 2020

Regulation of p53 stability and function by the deubiquitinating enzyme USP42

1 reference

12 December 2020

Selective and cell-active inhibitors of the USP1/ UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cells

1 reference

12 December 2020

Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes

1 reference

12 December 2020

Domain analysis reveals that a deubiquitinating enzyme USP13 performs non-activating catalysis for Lys63-linked polyubiquitin

1 reference

12 December 2020

USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma

1 reference

12 December 2020

Chalcone-based small-molecule inhibitors attenuate malignant phenotype via targeting deubiquitinating enzymes

1 reference

12 December 2020

Indoleamine 2,3-dioxygenase expression and functional activity in dendritic cells exposed to cholera toxin

1 reference

12 December 2020

Discovery of specific inhibitors of human USP7/HAUSP deubiquitinating enzyme

1 reference

12 December 2020

MYC is activated by USP2a-mediated modulation of microRNAs in prostate cancer

1 reference

12 December 2020

Ubiquitin-specific protease 25 functions in Endoplasmic Reticulum-associated degradation

1 reference

12 December 2020

USP2a negatively regulates IL-1β- and virus-induced NF-κB activation by deubiquitinating TRAF6.

1 reference

12 December 2020

The deubiquitylase USP37 links REST to the control of p27 stability and cell proliferation

1 reference

12 December 2020

USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor

1 reference

12 December 2020

Ubiquitin removal in the TGF-β pathway

1 reference

12 December 2020

STAT3 repressed USP7 expression is crucial for colon cancer development

1 reference

12 December 2020

USP11 augments TGFβ signalling by deubiquitylating ALK5.

1 reference

12 December 2020

Antiviral activity of a small molecule deubiquitinase inhibitor occurs via induction of the unfolded protein response

1 reference

12 December 2020

CYLD inhibits melanoma growth and progression through suppression of the JNK/AP-1 and β1-integrin signaling pathways

1 reference

12 December 2020

A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance

1 reference

12 December 2020

The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability

1 reference

12 December 2020

The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation.

1 reference

12 December 2020

The deubiquitinating enzyme USP37 regulates the oncogenic fusion protein PLZF/RARA stability

1 reference

12 December 2020

A Strategy for Modulation of Enzymes in the Ubiquitin System

1 reference

12 December 2020

Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3

1 reference

12 December 2020

Up-regulation of USP2a and FASN in gliomas correlates strongly with glioma grade

1 reference

12 December 2020

USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110

1 reference

12 December 2020

The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells

1 reference

12 December 2020

Ubiquitin-specific protease 25 regulates TLR4-dependent innate immune responses through deubiquitination of the adaptor protein TRAF3.

1 reference

12 December 2020

Mitoxantrone targets human ubiquitin-specific peptidase 11 (USP11) and is a potent inhibitor of pancreatic cancer cell survival

1 reference

12 December 2020

Deubiquitinase inhibition of 19S regulatory particles by 4-arylidene curcumin analog AC17 causes NF-κB inhibition and p53 reactivation in human lung cancer cells.

1 reference

12 December 2020

Over-expression of deubiquitinating enzyme USP14 in lung adenocarcinoma promotes proliferation through the accumulation of β-catenin

1 reference

12 December 2020

USP15 negatively regulates Nrf2 through deubiquitination of Keap1.

1 reference

12 December 2020

USP8 is a novel target for overcoming gefitinib resistance in lung cancer

1 reference

12 December 2020

Vialinin A is a ubiquitin-specific peptidase inhibitor

1 reference

12 December 2020

USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing

1 reference

12 December 2020

USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex

1 reference

12 December 2020

Deubiquitylases from genes to organism

1 reference

12 December 2020

Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling

1 reference

12 December 2020

Deubiquitinating enzyme Usp12 is a novel co-activator of the androgen receptor.

1 reference

12 December 2020

CYLD controls c-MYC expression through the JNK-dependent signaling pathway in hepatocellular carcinoma.

1 reference

12 December 2020

The deubiquitinating enzyme USP17 is associated with non-small cell lung cancer (NSCLC) recurrence and metastasis.

1 reference

12 December 2020

Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells.

1 reference

12 December 2020

USP9X expression correlates with tumor progression and poor prognosis in esophageal squamous cell carcinoma

1 reference

12 December 2020

USP3 counteracts RNF168 via deubiquitinating H2A and γH2AX at lysine 13 and 15.

1 reference

12 December 2020

USP22 regulates oncogenic signaling pathways to drive lethal cancer progression

1 reference

12 December 2020

Ubiquitin-specific proteases 25 negatively regulates virus-induced type I interferon signaling

1 reference

12 December 2020

USP3 controls BRCA1 "foci".

1 reference

12 December 2020

A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance

1 reference

12 December 2020

USP10 antagonizes c-Myc transcriptional activation through SIRT6 stabilization to suppress tumor formation

1 reference

12 December 2020

Metformin inhibits esophagus cancer proliferation through upregulation of USP7.

1 reference

12 December 2020

Prognostic significance of USP10 as a tumor-associated marker in gastric carcinoma

1 reference

12 December 2020

Characterization of the deubiquitinating activity of USP19 and its role in endoplasmic reticulum-associated degradation

1 reference

12 December 2020

Ubiquitin-specific protease 2a stabilizes MDM4 and facilitates the p53-mediated intrinsic apoptotic pathway in glioblastoma

1 reference

12 December 2020

Ubiquitin-specific protease 5 is required for the efficient repair of DNA double-strand breaks

1 reference

12 December 2020

Selective and reversible inhibitors of ubiquitin-specific protease 7: a patent evaluation (WO2013030218).

1 reference

12 December 2020

Ubiquitin-specific peptidase 22, a histone deubiquitinating enzyme, is a novel poor prognostic factor for salivary adenoid cystic carcinoma

1 reference

12 December 2020

USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase

1 reference

12 December 2020

A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30

1 reference

12 December 2020

A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses.

1 reference

12 December 2020

Ubiquitin-specific protease 22: a novel molecular biomarker in glioma prognosis and therapeutics.

1 reference

12 December 2020

USP29 controls the stability of checkpoint adaptor Claspin by deubiquitination.

1 reference

12 December 2020

USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses

1 reference

12 December 2020

Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47.

1 reference

12 December 2020

Usp5 links suppression of p53 and FAS levels in melanoma to the BRAF pathway

1 reference

12 December 2020

Tumor-associated macrophages as major players in the tumor microenvironment

1 reference

12 December 2020

Deubiquitination and stabilization of IL-33 by USP21.

1 reference

12 December 2020

Deubiquitinating enzyme Usp12 regulates the interaction between the androgen receptor and the Akt pathway.

1 reference

12 December 2020

USP37 directly deubiquitinates and stabilizes c-Myc in lung cancer

1 reference

12 December 2020

The histone H2A deubiquitinase USP16 interacts with HERC2 and fine-tunes cellular response to DNA damage

1 reference

12 December 2020

Ubiquitin specific protease 22 promotes cell proliferation and tumor growth of epithelial ovarian cancer through synergy with transforming growth factor β1.

1 reference

12 December 2020

Deubiquitinase inhibition as a cancer therapeutic strategy

1 reference

12 December 2020

The deubiquitinating enzyme USP24 is a regulator of the UV damage response

1 reference

12 December 2020

Ubiquitin specific protease 21 is dispensable for normal development, hematopoiesis and lymphocyte differentiation

1 reference

12 December 2020

USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell death

1 reference

12 December 2020

Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies

1 reference

12 December 2020

Deubiquitinating enzymes as oncotargets

1 reference

12 December 2020

Deubiquitinases in cancer

1 reference

12 December 2020

The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80.

1 reference

12 December 2020

Ubiquitin specific protease 4 positively regulates the WNT/β-catenin signaling in colorectal cancer

1 reference

12 December 2020

USP18 negatively regulates NF-κB signaling by targeting TAK1 and NEMO for deubiquitination through distinct mechanisms

1 reference

12 December 2020

USP35 activated by miR let-7a inhibits cell proliferation and NF-κB activation through stabilization of ABIN-2

1 reference

12 December 2020

USP4 inhibits p53 and NF-κB through deubiquitinating and stabilizing HDAC2.

1 reference

12 December 2020

Deubiquitinating c-Myc: USP36 steps up in the nucleolus

1 reference

12 December 2020

USP7 Enforces Heterochromatinization of p53 Target Promoters by Protecting SUV39H1 from MDM2-Mediated Degradation

1 reference

12 December 2020

Ubiquitin modifications

1 reference

12 December 2020

The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis

1 reference

12 December 2020

The Roles of MDM2 and MDMX in Cancer.

1 reference

12 December 2020

ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth.

1 reference

12 December 2020

Expression of USP7 and MARCH7 Is Correlated with Poor Prognosis in Epithelial Ovarian Cancer.

1 reference

12 December 2020

USP7 promotes cell proliferation through the stabilization of Ki-67 protein in non-small cell lung cancer cells

1 reference

12 December 2020

Wnt signaling in cancer.

1 reference

12 December 2020

Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models

1 reference

12 December 2020

USP44 Is an Integral Component of N-CoR that Contributes to Gene Repression by Deubiquitinating Histone H2B.

1 reference

12 December 2020

The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog.

1 reference

12 December 2020

TGF-β upregulates the translation of USP15 via the PI3K/AKT pathway to promote p53 stability

1 reference

12 December 2020

The bad seed gardener: Deubiquitinases in the cancer stem-cell signaling network and therapeutic resistance

1 reference

12 December 2020

New Mechanisms of Tumor-Associated Macrophages on Promoting Tumor Progression: Recent Research Advances and Potential Targets for Tumor Immunotherapy

1 reference

12 December 2020

EGF-mediated inhibition of ubiquitin-specific peptidase 24 expression has a crucial role in tumorigenesis

1 reference

12 December 2020

Aberrant Phosphorylation of SMAD4 Thr277-Mediated USP9x-SMAD4 Interaction by Free Fatty Acids Promotes Breast Cancer Metastasis

1 reference

12 December 2020

Deubiquitinating enzyme USP22 positively regulates c-Myc stability and tumorigenic activity in mammalian and breast cancer cells.

1 reference

12 December 2020

USP22 maintains gastric cancer stem cell stemness and promotes gastric cancer progression by stabilizing BMI1 protein

1 reference

12 December 2020

Regulation of Ubiquitin Enzymes in the TGF-β Pathway.

1 reference

12 December 2020

USP22 knockdown enhanced chemosensitivity of hepatocellular carcinoma cells to 5-Fu by up-regulation of Smad4 and suppression of Akt.

1 reference

12 December 2020

Progress in tumor-associated macrophage (TAM)-targeted therapeutics

1 reference

12 December 2020

Mechanisms of Deubiquitinase Specificity and Regulation.

1 reference

12 December 2020

Inhibition of ubiquitin-specific protease 34 (USP34) induces epithelial-mesenchymal transition and promotes stemness in mammary epithelial cells.

1 reference

12 December 2020

High ubiquitin-specific protease 44 expression induces DNA aneuploidy and provides independent prognostic information in gastric cancer

1 reference

12 December 2020

USP22 Induces Cisplatin Resistance in Lung Adenocarcinoma by Regulating γH2AX-Mediated DNA Damage Repair and Ku70/Bax-Mediated Apoptosis

1 reference

12 December 2020

Downregulated USP3 mRNA functions as a competitive endogenous RNA of SMAD4 by sponging miR-224 and promotes metastasis in colorectal cancer

1 reference

12 December 2020

Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth

1 reference

12 December 2020

Dub3 controls DNA damage signalling by direct deubiquitination of H2AX.

1 reference

12 December 2020

Loss of Usp9x disrupts cell adhesion, and components of the Wnt and Notch signaling pathways in neural progenitors

1 reference

12 December 2020

USP10 inhibits lung cancer cell growth and invasion by upregulating PTEN.

1 reference

12 December 2020

Mechanism and regulation of the Lys6-selective deubiquitinase USP30.

1 reference

12 December 2020

Inhibition of USP10 induces degradation of oncogenic FLT3.

1 reference

12 December 2020

Hypoxia induces epithelial-mesenchymal transition in colorectal cancer cells through ubiquitin-specific protease 47-mediated stabilization of Snail: A potential role of Sox9.

1 reference

12 December 2020

TGF-β signaling in cancer metastasis.

1 reference

12 December 2020

Discovery and characterization of highly potent and selective allosteric USP7 inhibitors

1 reference

12 December 2020

Targeting mutant p53 for efficient cancer therapy.

1 reference

12 December 2020

Regulation of the Mdm2-p53 pathway by the ubiquitin E3 ligase MARCH7.

1 reference

12 December 2020

Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors

1 reference

12 December 2020

Association of USP10 with G3BP2 Inhibits p53 Signaling and Contributes to Poor Outcome in Prostate Cancer

1 reference

12 December 2020

USP35 regulates mitotic progression by modulating the stability of Aurora B.

1 reference

12 December 2020

YAP1-Mediated Suppression of USP31 Enhances NFκB Activity to Promote Sarcomagenesis.

1 reference

12 December 2020

Deubiquitylation and stabilization of p21 by USP11 is critical for cell-cycle progression and DNA damage responses.

1 reference

12 December 2020

Deubiquitinating enzyme USP3 controls CHK1 chromatin association and activation.

1 reference

12 December 2020

USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism

1 reference

12 December 2020

USP22 promotes resistance to EGFR-TKIs by preventing ubiquitination-mediated EGFR degradation in EGFR-mutant lung adenocarcinoma

1 reference

12 December 2020

Discovering proteasomal deubiquitinating enzyme inhibitors for cancer therapy: lessons from rational design, nature and old drug reposition

1 reference

12 December 2020

Knockdown of USP28 enhances the radiosensitivity of esophageal cancer cells via the c-Myc/hypoxia-inducible factor-1 alpha pathway

1 reference

12 December 2020

Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells

1 reference

12 December 2020

USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and β-TrCP and promotes cancer malignancy

1 reference

12 December 2020

Protein Language: Post-Translational Modifications Talking to Each Other

1 reference

12 December 2020

USP14 as a novel prognostic marker promotes cisplatin resistance via Akt/ERK signaling pathways in gastric cancer

1 reference

12 December 2020

Inhibition of Ubiquitin-Specific Proteases as a Novel Anticancer Therapeutic Strategy

1 reference

12 December 2020

TGF-β signaling pathway mediated by deubiquitinating enzymes

1 reference

12 December 2020

H19/miR-148a/USP4 axis facilitates liver fibrosis by enhancing TGF-β signaling in both hepatic stellate cells and hepatocytes

1 reference

12 December 2020

Identification and Characterization of USP7 Targets in Cancer Cells

1 reference

12 December 2020

UniProt: a worldwide hub of protein knowledge

1 reference

12 December 2020

A Novel and Cytogenetically Cryptic t(7;21)(q36.1;q22) Disrupting RUNX1 in Acute Myeloid Leukemia

1 reference

12 December 2020

USP28 contributes to the proliferation and metastasis of gastric cancer

1 reference

12 December 2020

Upregulation of USP11 promotes epithelial‑to‑mesenchymal transition by deubiquitinating Snail in ovarian cancer

1 reference

12 December 2020

The Autophagy Inhibitor Spautin-1 Antagonizes Rescue of Mutant CFTR Through an Autophagy-Independent and USP13-Mediated Mechanism

1 reference

12 December 2020

USP44 Promotes the Tumorigenesis of Prostate Cancer Cells through EZH2 Protein Stabilization

1 reference

12 December 2020

Breaking the chains: deubiquitylating enzyme specificity begets function

1 reference

12 December 2020

The Scope, Functions, and Dynamics of Posttranslational Protein Modifications

1 reference

12 December 2020

10.1186/S12929-019-0522-0

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31133011%20AND%20SRC:MED&resulttype=core&format=json

28 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31133011%20AND%20SRC:MED&resulttype=core&format=json

28 April 2020

PubMed publication ID

31133011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31133011%20AND%20SRC:MED&resulttype=core&format=json