USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor (Q84393677)

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scientific article published on 17 June 2012

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English	USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor	scientific article published on 17 June 2012

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title

USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor (English)

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22706160

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Long Zhang

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1

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FangFang Zhou

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Yvette Drabsch

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3

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Rui Gao

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4

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22706160

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B Ewa Snaar-Jagalska

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Craig Mickanin

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6

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Huizhe Huang

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Kelly-Ann Sheppard

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Jeff A Porter

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9

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Chris X Lu

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10

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22706160

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Peter ten Dijke

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11

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22706160

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publication date

17 June 2012

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5 February 2020

published in

Nature Cell Biology

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22706160

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volume

14

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22706160

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issue

7

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page(s)

717-726

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USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1

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USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma

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TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains.

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USP10 regulates p53 localization and stability by deubiquitinating p53

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fgf17b, a novel member of Fgf family, helps patterning zebrafish embryos

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Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

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PKB/Akt modulates TGF-beta signalling through a direct interaction with Smad3.

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14-3-3 Proteins: Diverse functions in cell proliferation and cancer progression

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TGFbeta signalling: a complex web in cancer progression

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The mammalian gene collection

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A multigenic program mediating breast cancer metastasis to bone

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Hox gene expression reveals regionalization along the anteroposterior axis of the zebrafish notochord.

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Will the Ubiquitin System Furnish as Many Drug Targets as Protein Kinases?

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New regulatory mechanisms of TGF-beta receptor function

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Smad3 protein levels are modulated by Ras activity and during the cell cycle to dictate transforming growth factor-beta responses

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The many forks in FOXO's road

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Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

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CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression

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UnpEL/Usp4 is ubiquitinated by Ro52 and deubiquitinated by itself

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12 December 2020

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Non-Smad pathways in TGF-beta signaling

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12 December 2020

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Ubiquitin-dependent degradation of TGF-beta-activated smad2.

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12 December 2020

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Akt interacts directly with Smad3 to regulate the sensitivity to TGF-beta induced apoptosis

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12 December 2020

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Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases.

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12 December 2020

based on heuristic

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Key role for ubiquitin protein modification in TGFβ signal transduction

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12 December 2020

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Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

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Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNFα-induced cancer cell migration.

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Neutrophil-mediated experimental metastasis is enhanced by VEGFR inhibition in a zebrafish xenograft model.

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A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

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Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

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Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors

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AKT/PKB signaling: navigating downstream

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https://pubmed.ncbi.nlm.nih.gov/22706160

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based on heuristic

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Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane

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https://pubmed.ncbi.nlm.nih.gov/22706160

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Inhibition of pulmonary and skeletal metastasis by a transforming growth factor-beta type I receptor kinase inhibitor

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The regulation of TGFbeta signal transduction

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TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells

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12 December 2020

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USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma

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12 December 2020

based on heuristic

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Noncanonical TGF-β Signaling During Mammary Tumorigenesis

1 reference

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12 December 2020

based on heuristic

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Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

1 reference

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12 December 2020

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Loss of the Smad3 expression increases susceptibility to tumorigenicity in human gastric cancer.

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A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis

1 reference

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12 December 2020

based on heuristic

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USP15 is a deubiquitylating enzyme for receptor-activated SMADs

1 reference

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https://pubmed.ncbi.nlm.nih.gov/22706160

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12 December 2020

based on heuristic

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A genomic and functional inventory of deubiquitinating enzymes

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP4 targets TAK1 to downregulate TNFα-induced NF-κB activation

1 reference

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12 December 2020

based on heuristic

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A positive role for Myc in TGFbeta-induced Snail transcription and epithelial-to-mesenchymal transition

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TGF-β-induced activation of mTOR complex 2 drives epithelial-mesenchymal transition and cell invasion

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12 December 2020

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Activated type I TGFbeta receptor kinase enhances the survival of mammary epithelial cells and accelerates tumor progression

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12 December 2020

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Ubiquitin-specific protease 4 mitigates Toll-like/interleukin-1 receptor signaling and regulates innate immune activation.

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12 December 2020

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Regulating the stability of TGFbeta receptors and Smads

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Identifiers

DOI

10.1038/NCB2522

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PubMed publication ID

22706160

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22706160%20AND%20SRC:MED&resulttype=core&format=json

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5 February 2020

Dimensions Publication ID

1034815752

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PubMed publication ID

22706160

1 reference

stated in

Europe PubMed Central

PubMed publication ID

22706160

reference URL

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22706160%20AND%20SRC:MED&resulttype=core&format=json

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5 February 2020

 

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