Inhibition of Ubiquitin-Specific Proteases as a Novel Anticancer Therapeutic Strategy (Q57490982)

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Meidan Ying

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Ji Cao

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Qiaojun He

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Hong Zhu

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Bo Yang

Frontiers in Pharmacology

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language of work or name

English

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publication date

2018

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published in

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volume

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page(s)

1080

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Creative Commons Attribution 4.0 International

start time

27 September 2018

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April 2022 Public Data File from Crossref

copyrighted

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cites work

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Inhibition of USP10 induces degradation of oncogenic FLT3.

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Deubiquitinating Enzyme USP9X Suppresses Tumor Growth via LATS Kinase and Core Components of the Hippo Pathway.

2 November 2018

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USP9X regulates centrosome duplication and promotes breast carcinogenesis

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Modulation of the p53/MDM2 interplay by HAUSP inhibitors

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The bad seed gardener: Deubiquitinases in the cancer stem-cell signaling network and therapeutic resistance

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Amplification of USP13 drives ovarian cancer metabolism

2 November 2018

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Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models

2 November 2018

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USP14 de-ubiquitinates vimentin and miR-320a modulates USP14 and vimentin to contribute to malignancy in gastric cancer cells

2 November 2018

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Deubiquitinases and cancer: A snapshot

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Ubiquitin-specific protease 7 expression is a prognostic factor in epithelial ovarian cancer and correlates with lymph node metastasis

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Deubiquitination and Activation of AMPK by USP10

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Recent Advances in the Discovery of Deubiquitinating Enzyme Inhibitors

2 November 2018

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Decision for cell fate: deubiquitinating enzymes in cell cycle checkpoint

2 November 2018

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Downregulation of ubiquitin-specific protease 14 (USP14) inhibits breast cancer cell proliferation and metastasis, but promotes apoptosis

2 November 2018

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Inhibition of proteasome deubiquitinase activity: a strategy to overcome resistance to conventional proteasome inhibitors?

2 November 2018

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Deubiquitinases in cancer

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Deubiquitinating enzymes as oncotargets

2 November 2018

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Ubiquitin-specific proteases as therapeutic targets for the treatment of breast cancer

2 November 2018

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Deubiquitinases and the new therapeutic opportunities offered to cancer

2 November 2018

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USP7 overexpression predicts a poor prognosis in lung squamous cell carcinoma and large cell carcinoma

2 November 2018

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Deubiquitinase inhibition as a cancer therapeutic strategy

2 November 2018

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Parkin-mediated K63-polyubiquitination targets ubiquitin C-terminal hydrolase L1 for degradation by the autophagy-lysosome system

2 November 2018

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SCF ubiquitin ligase-targeted therapies.

2 November 2018

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Emerging potential of therapeutic targeting of ubiquitin-specific proteases in the treatment of cancer.

2 November 2018

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A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses.

2 November 2018

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A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance

2 November 2018

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USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis

2 November 2018

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The deubiquitinating enzyme USP17 is associated with non-small cell lung cancer (NSCLC) recurrence and metastasis.

2 November 2018

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2 November 2018

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The WD40-repeat protein-containing deubiquitinase complex: catalysis, regulation, and potential for therapeutic intervention

2 November 2018

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Vialinin A is a ubiquitin-specific peptidase inhibitor

2 November 2018

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Over-expression of deubiquitinating enzyme USP14 in lung adenocarcinoma promotes proliferation through the accumulation of β-catenin

2 November 2018

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Expression of HAUSP in gliomas correlates with disease progression and survival of patients

2 November 2018

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A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance

2 November 2018

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Discovery of specific inhibitors of human USP7/HAUSP deubiquitinating enzyme

2 November 2018

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The ubiquitin-specific protease USP2a enhances tumor progression by targeting cyclin A1 in bladder cancer

2 November 2018

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USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma

2 November 2018

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Inhibition of proteasome deubiquitinating activity as a new cancer therapy

2 November 2018

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Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13

2 November 2018

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USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma

2 November 2018

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DUB-le Trouble for Cell Survival

2 November 2018

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USP10 regulates p53 localization and stability by deubiquitinating p53

2 November 2018

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Emerging roles of deubiquitinases in cancer-associated pathways

2 November 2018

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Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

2 November 2018

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Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells

2 November 2018

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Breaking the chains: structure and function of the deubiquitinases

2 November 2018

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2 November 2018

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A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway

2 November 2018

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Regulation of monoubiquitinated PCNA by DUB autocleavage

2 November 2018

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Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14

2 November 2018

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The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway

2 November 2018

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2 November 2018

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