The role of ubiquitin-specific peptidases in cancer progression (Q64288182)

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scientific article published on 27 May 2019

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English	The role of ubiquitin-specific peptidases in cancer progression	scientific article published on 27 May 2019

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scholarly article

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28 April 2020

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Europe PubMed Central

29 October 2020

8 February 2021

The role of ubiquitin-specific peptidases in cancer progression (English)

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28 April 2020

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disease progression

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29 October 2020

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8 February 2021

5

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28 April 2020

author name string

Ming-Jer Young

1

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28 April 2020

Kai-Cheng Hsu

2

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28 April 2020

Tony Eight Lin

3

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28 April 2020

Wen-Chang Chang

4

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28 April 2020

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publication date

27 May 2019

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28 April 2020

29 October 2020

8 February 2021

Journal of Biomedical Science

3 references

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28 April 2020

29 October 2020

8 February 2021

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28 April 2020

1

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Europe PubMed Central

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28 April 2020

42

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28 April 2020

copyright license

Creative Commons Attribution 4.0 International

2 references

Europe PubMed Central

29 October 2020

Europe PubMed Central

8 February 2021

Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An azoospermic man with a de novo point mutation in the Y-chromosomal gene USP9Y

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An abundance of X-linked genes expressed in spermatogonia

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two isoforms of otubain 1 regulate T cell anergy via GRAIL

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A dynamic role of HAUSP in the p53-Mdm2 pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APC/C and SCF: controlling each other and the cell cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel mutations in testis-specific ubiquitin protease 26 gene may cause male infertility and hypogonadism

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A leukemia-enriched cDNA microarray platform identifies new transcripts with relevance to the biology of pediatric acute lymphoblastic leukemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitylation and cell signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A genomic and functional inventory of deubiquitinating enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel and cytogenetically cryptic t(7;21)(p22;q22) in acute myeloid leukemia results in fusion of RUNX1 with the ubiquitin-specific protease gene USP42.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein degradation by the ubiquitin-proteasome pathway in normal and disease states

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of a novel Bcr/Abl destruction pathway by WP1130 induces apoptosis of chronic myelogenous leukemia cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitination regulates PTEN nuclear import and tumor suppression

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubp43 regulates BCR-ABL leukemogenesis via the type 1 interferon receptor signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fbw7 and Usp28 regulate myc protein stability in response to DNA damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of cell cycle progression and gene expression by H2A deubiquitination

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human USP3 is a chromatin modifier required for S phase progression and genome stability

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of mitochondrial morphology by USP30, a deubiquitinating enzyme present in the mitochondrial outer membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of IkappaB kinase-related kinases and antiviral responses by tumor suppressor CYLD.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP22, an hSAGA subunit and potential cancer stem cell marker, reverses the polycomb-catalyzed ubiquitylation of histone H2A

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The tumour suppressor CYLD is a negative regulator of RIG-I-mediated antiviral response

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genome profiling of chronic myelomonocytic leukemia: frequent alterations of RAS and RUNX1 genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lysine 63-linked polyubiquitin chain may serve as a targeting signal for the 26S proteasome

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recognition and processing of ubiquitin-protein conjugates by the proteasome

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Breaking the chains: structure and function of the deubiquitinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MdmX is a substrate for the deubiquitinating enzyme USP2a

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP11 negatively regulates TNFalpha-induced NF-kappaB activation by targeting on IkappaBalpha.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Suppression of cancer cell growth by promoting cyclin D1 degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Emerging roles of deubiquitinases in cancer-associated pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP10 regulates p53 localization and stability by deubiquitinating p53

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signaling to NF-kappaB: regulation by ubiquitination

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin-specific protease 8 links the PTEN-Akt-AIP4 pathway to the control of FLIPS stability and TRAIL sensitivity in glioblastoma multiforme

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The deubiquitinating enzyme USP26 is a regulator of androgen receptor signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP32 is an active, membrane-bound ubiquitin protease overexpressed in breast cancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Deubiquitinating Enzyme USP8 Promotes Trafficking and Degradation of the Chemokine Receptor 4 at the Sorting Endosome

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A screen for deubiquitinating enzymes involved in the G₂/M checkpoint identifies USP50 as a regulator of HSP90-dependent Wee1 stability.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin becomes ubiquitous in cancer: emerging roles of ubiquitin ligases and deubiquitinases in tumorigenesis and as therapeutic targets

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deubiquitinase inhibition by small-molecule WP1130 triggers aggresome formation and tumor cell apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

JTV1 co-activates FBP to induce USP29 transcription and stabilize p53 in response to oxidative stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP4 targets TAK1 to downregulate TNFα-induced NF-κB activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase β

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ubiquitin-specific protease USP34 regulates axin stability and Wnt/β-catenin signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disruption of the MDM2-p53 interaction strongly potentiates p53-dependent apoptosis in cisplatin-resistant human testicular carcinoma cells via the Fas/FasL pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin-specific peptidase 20 targets TRAF6 and human T cell leukemia virus type 1 tax to negatively regulate NF-kappaB signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 regulation by ubiquitin

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel small molecule deubiquitinase inhibitor blocks Jak2 signaling through Jak2 ubiquitination

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP22 acts as an oncogene by the activation of BMI-1-mediated INK4a/ARF pathway and Akt pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP15 is a deubiquitylating enzyme for receptor-activated SMADs

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PTBP1-dependent regulation of USP5 alternative RNA splicing plays a role in glioblastoma tumorigenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNFα-induced cancer cell migration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Atypical mechanism of NF-κB activation by TRE17/ubiquitin-specific protease 6 (USP6) oncogene and its requirement in tumorigenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of p53 stability and function by the deubiquitinating enzyme USP42

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective and cell-active inhibitors of the USP1/ UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Domain analysis reveals that a deubiquitinating enzyme USP13 performs non-activating catalysis for Lys63-linked polyubiquitin

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chalcone-based small-molecule inhibitors attenuate malignant phenotype via targeting deubiquitinating enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Indoleamine 2,3-dioxygenase expression and functional activity in dendritic cells exposed to cholera toxin

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of specific inhibitors of human USP7/HAUSP deubiquitinating enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MYC is activated by USP2a-mediated modulation of microRNAs in prostate cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin-specific protease 25 functions in Endoplasmic Reticulum-associated degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP2a negatively regulates IL-1β- and virus-induced NF-κB activation by deubiquitinating TRAF6.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The deubiquitylase USP37 links REST to the control of p27 stability and cell proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP4 is regulated by AKT phosphorylation and directly deubiquitylates TGF-β type I receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin removal in the TGF-β pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

STAT3 repressed USP7 expression is crucial for colon cancer development

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP11 augments TGFβ signalling by deubiquitylating ALK5.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiviral activity of a small molecule deubiquitinase inhibitor occurs via induction of the unfolded protein response

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CYLD inhibits melanoma growth and progression through suppression of the JNK/AP-1 and β1-integrin signaling pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The deubiquitinating enzyme USP37 regulates the oncogenic fusion protein PLZF/RARA stability

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Strategy for Modulation of Enzymes in the Ubiquitin System

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Up-regulation of USP2a and FASN in gliomas correlates strongly with glioma grade

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin-specific protease 25 regulates TLR4-dependent innate immune responses through deubiquitination of the adaptor protein TRAF3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitoxantrone targets human ubiquitin-specific peptidase 11 (USP11) and is a potent inhibitor of pancreatic cancer cell survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deubiquitinase inhibition of 19S regulatory particles by 4-arylidene curcumin analog AC17 causes NF-κB inhibition and p53 reactivation in human lung cancer cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Over-expression of deubiquitinating enzyme USP14 in lung adenocarcinoma promotes proliferation through the accumulation of β-catenin

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP15 negatively regulates Nrf2 through deubiquitination of Keap1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP8 is a novel target for overcoming gefitinib resistance in lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vialinin A is a ubiquitin-specific peptidase inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicing

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deubiquitylases from genes to organism

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deubiquitinating enzyme Usp12 is a novel co-activator of the androgen receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CYLD controls c-MYC expression through the JNK-dependent signaling pathway in hepatocellular carcinoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The deubiquitinating enzyme USP17 is associated with non-small cell lung cancer (NSCLC) recurrence and metastasis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP9X expression correlates with tumor progression and poor prognosis in esophageal squamous cell carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP3 counteracts RNF168 via deubiquitinating H2A and γH2AX at lysine 13 and 15.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP22 regulates oncogenic signaling pathways to drive lethal cancer progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin-specific proteases 25 negatively regulates virus-induced type I interferon signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP3 controls BRCA1 "foci".

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP10 antagonizes c-Myc transcriptional activation through SIRT6 stabilization to suppress tumor formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metformin inhibits esophagus cancer proliferation through upregulation of USP7.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prognostic significance of USP10 as a tumor-associated marker in gastric carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the deubiquitinating activity of USP19 and its role in endoplasmic reticulum-associated degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin-specific protease 2a stabilizes MDM4 and facilitates the p53-mediated intrinsic apoptotic pathway in glioblastoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin-specific protease 5 is required for the efficient repair of DNA double-strand breaks

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective and reversible inhibitors of ubiquitin-specific protease 7: a patent evaluation (WO2013030218).

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin-specific peptidase 22, a histone deubiquitinating enzyme, is a novel poor prognostic factor for salivary adenoid cystic carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin-specific protease 22: a novel molecular biomarker in glioma prognosis and therapeutics.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP29 controls the stability of checkpoint adaptor Claspin by deubiquitination.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective Dual Inhibitors of the Cancer-Related Deubiquitylating Proteases USP7 and USP47.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Usp5 links suppression of p53 and FAS levels in melanoma to the BRAF pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor-associated macrophages as major players in the tumor microenvironment

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deubiquitination and stabilization of IL-33 by USP21.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deubiquitinating enzyme Usp12 regulates the interaction between the androgen receptor and the Akt pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP37 directly deubiquitinates and stabilizes c-Myc in lung cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The histone H2A deubiquitinase USP16 interacts with HERC2 and fine-tunes cellular response to DNA damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin specific protease 22 promotes cell proliferation and tumor growth of epithelial ovarian cancer through synergy with transforming growth factor β1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deubiquitinase inhibition as a cancer therapeutic strategy

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The deubiquitinating enzyme USP24 is a regulator of the UV damage response

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin specific protease 21 is dispensable for normal development, hematopoiesis and lymphocyte differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP30 deubiquitylates mitochondrial Parkin substrates and restricts apoptotic cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deubiquitinating enzymes as oncotargets

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deubiquitinases in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin specific protease 4 positively regulates the WNT/β-catenin signaling in colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP18 negatively regulates NF-κB signaling by targeting TAK1 and NEMO for deubiquitination through distinct mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP35 activated by miR let-7a inhibits cell proliferation and NF-κB activation through stabilization of ABIN-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP4 inhibits p53 and NF-κB through deubiquitinating and stabilizing HDAC2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deubiquitinating c-Myc: USP36 steps up in the nucleolus

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP7 Enforces Heterochromatinization of p53 Target Promoters by Protecting SUV39H1 from MDM2-Mediated Degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin modifications

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The deubiquitinase Usp27x stabilizes the BH3-only protein Bim and enhances apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Roles of MDM2 and MDMX in Cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ATXN7L3 and ENY2 Coordinate Activity of Multiple H2B Deubiquitinases Important for Cellular Proliferation and Tumor Growth.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of USP7 and MARCH7 Is Correlated with Poor Prognosis in Epithelial Ovarian Cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP7 promotes cell proliferation through the stabilization of Ki-67 protein in non-small cell lung cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt signaling in cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP44 Is an Integral Component of N-CoR that Contributes to Gene Repression by Deubiquitinating Histone H2B.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TGF-β upregulates the translation of USP15 via the PI3K/AKT pathway to promote p53 stability

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The bad seed gardener: Deubiquitinases in the cancer stem-cell signaling network and therapeutic resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New Mechanisms of Tumor-Associated Macrophages on Promoting Tumor Progression: Recent Research Advances and Potential Targets for Tumor Immunotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EGF-mediated inhibition of ubiquitin-specific peptidase 24 expression has a crucial role in tumorigenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant Phosphorylation of SMAD4 Thr277-Mediated USP9x-SMAD4 Interaction by Free Fatty Acids Promotes Breast Cancer Metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deubiquitinating enzyme USP22 positively regulates c-Myc stability and tumorigenic activity in mammalian and breast cancer cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP22 maintains gastric cancer stem cell stemness and promotes gastric cancer progression by stabilizing BMI1 protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of Ubiquitin Enzymes in the TGF-β Pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP22 knockdown enhanced chemosensitivity of hepatocellular carcinoma cells to 5-Fu by up-regulation of Smad4 and suppression of Akt.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progress in tumor-associated macrophage (TAM)-targeted therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of Deubiquitinase Specificity and Regulation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of ubiquitin-specific protease 34 (USP34) induces epithelial-mesenchymal transition and promotes stemness in mammary epithelial cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High ubiquitin-specific protease 44 expression induces DNA aneuploidy and provides independent prognostic information in gastric cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP22 Induces Cisplatin Resistance in Lung Adenocarcinoma by Regulating γH2AX-Mediated DNA Damage Repair and Ku70/Bax-Mediated Apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Downregulated USP3 mRNA functions as a competitive endogenous RNA of SMAD4 by sponging miR-224 and promotes metastasis in colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA repair and tumor growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dub3 controls DNA damage signalling by direct deubiquitination of H2AX.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of Usp9x disrupts cell adhesion, and components of the Wnt and Notch signaling pathways in neural progenitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP10 inhibits lung cancer cell growth and invasion by upregulating PTEN.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism and regulation of the Lys6-selective deubiquitinase USP30.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of USP10 induces degradation of oncogenic FLT3.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hypoxia induces epithelial-mesenchymal transition in colorectal cancer cells through ubiquitin-specific protease 47-mediated stabilization of Snail: A potential role of Sox9.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TGF-β signaling in cancer metastasis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery and characterization of highly potent and selective allosteric USP7 inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting mutant p53 for efficient cancer therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of the Mdm2-p53 pathway by the ubiquitin E3 ligase MARCH7.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of USP10 with G3BP2 Inhibits p53 Signaling and Contributes to Poor Outcome in Prostate Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP35 regulates mitotic progression by modulating the stability of Aurora B.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

YAP1-Mediated Suppression of USP31 Enhances NFκB Activity to Promote Sarcomagenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deubiquitylation and stabilization of p21 by USP11 is critical for cell-cycle progression and DNA damage responses.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deubiquitinating enzyme USP3 controls CHK1 chromatin association and activation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP22 deficiency leads to myeloid leukemia upon oncogenic Kras activation through a PU.1-dependent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP22 promotes resistance to EGFR-TKIs by preventing ubiquitination-mediated EGFR degradation in EGFR-mutant lung adenocarcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovering proteasomal deubiquitinating enzyme inhibitors for cancer therapy: lessons from rational design, nature and old drug reposition

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Knockdown of USP28 enhances the radiosensitivity of esophageal cancer cells via the c-Myc/hypoxia-inducible factor-1 alpha pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of CCND1 ubiquitylation by the catalytic SAGA subunit USP22 is essential for cell cycle progression through G1 in cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and β-TrCP and promotes cancer malignancy

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein Language: Post-Translational Modifications Talking to Each Other

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP14 as a novel prognostic marker promotes cisplatin resistance via Akt/ERK signaling pathways in gastric cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of Ubiquitin-Specific Proteases as a Novel Anticancer Therapeutic Strategy

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TGF-β signaling pathway mediated by deubiquitinating enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

H19/miR-148a/USP4 axis facilitates liver fibrosis by enhancing TGF-β signaling in both hepatic stellate cells and hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and Characterization of USP7 Targets in Cancer Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

UniProt: a worldwide hub of protein knowledge

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A Novel and Cytogenetically Cryptic t(7;21)(q36.1;q22) Disrupting RUNX1 in Acute Myeloid Leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP28 contributes to the proliferation and metastasis of gastric cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Upregulation of USP11 promotes epithelial‑to‑mesenchymal transition by deubiquitinating Snail in ovarian cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Autophagy Inhibitor Spautin-1 Antagonizes Rescue of Mutant CFTR Through an Autophagy-Independent and USP13-Mediated Mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

USP44 Promotes the Tumorigenesis of Prostate Cancer Cells through EZH2 Protein Stabilization

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Breaking the chains: deubiquitylating enzyme specificity begets function

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Scope, Functions, and Dynamics of Posttranslational Protein Modifications

1 reference

https://pubmed.ncbi.nlm.nih.gov/31133011

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/S12929-019-0522-0

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31133011%20AND%20SRC:MED&resulttype=core&format=json

28 April 2020

PMC publication ID

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31133011%20AND%20SRC:MED&resulttype=core&format=json

28 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:31133011%20AND%20SRC:MED&resulttype=core&format=json

28 April 2020

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