Increasing Pyruvate Dehydrogenase Flux as a Treatment for Diabetic Cardiomyopathy: A Combined 13C Hyperpolarized Magnetic Resonance and Echocardiography Study (Q42394507)

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scientific article published on 20 March 2015

Language	Label	Description	Also known as
English	Increasing Pyruvate Dehydrogenase Flux as a Treatment for Diabetic Cardiomyopathy: A Combined 13C Hyperpolarized Magnetic Resonance and Echocardiography Study	scientific article published on 20 March 2015

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scholarly article

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Europe PubMed Central

PMC publication ID

29 October 2017

Increasing Pyruvate Dehydrogenase Flux as a Treatment for Diabetic Cardiomyopathy: A Combined 13C Hyperpolarized Magnetic Resonance and Echocardiography Study (English)

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Europe PubMed Central

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29 October 2017

echocardiography

1 reference

based on heuristic

inferred from title

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based on heuristic

inferred from title

diabetic cardiomyopathy

1 reference

based on heuristic

inferred from title

Damian J. Tyler

9

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25795215%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Lydia M Le Page

1

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7 June 2020

Carolyn A. Carr

7

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7 June 2020

author name string

Oliver J Rider

2

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7 June 2020

Andrew J Lewis

3

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7 June 2020

Vicky Ball

4

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7 June 2020

Kieran Clarke

5

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7 June 2020

Edvin Johansson

6

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7 June 2020

Lisa C Heather

8

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7 June 2020

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publication date

20 March 2015

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29 October 2017

number of pages

9

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7 June 2020

64

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7 June 2020

8

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7 June 2020

2735-2743

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7 June 2020

Clinical implications of cardiac hyperpolarized magnetic resonance imaging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516266

28 May 2018

Cardiac metabolism in a new rat model of type 2 diabetes using high-fat diet with low dose streptozotocin.

1 reference

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28 May 2018

ATP consumption by sarcoplasmic reticulum Ca²⁺ pumps accounts for 40-50% of resting metabolic rate in mouse fast and slow twitch skeletal muscle.

1 reference

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28 May 2018

Phenylbutyrate therapy for pyruvate dehydrogenase complex deficiency and lactic acidosis.

1 reference

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28 May 2018

Metabolic dysfunction in diabetic cardiomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516266

28 May 2018

Myocardial substrate metabolism in obesity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516266

28 May 2018

Diabetic cardiomyopathy: bench to bedside

1 reference

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28 May 2018

Role of pyruvate dehydrogenase inhibition in the development of hypertrophy in the hyperthyroid rat heart: a combined magnetic resonance imaging and hyperpolarized magnetic resonance spectroscopy study.

1 reference

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28 May 2018

Metabolism, hypoxia and the diabetic heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516266

28 May 2018

Validation of the in vivo assessment of pyruvate dehydrogenase activity using hyperpolarised 13C MRS.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516266

28 May 2018

Kinetic modeling of hyperpolarized 13C1-pyruvate metabolism in normal rats and TRAMP mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516266

28 May 2018

Peripheral neuropathy in rats exposed to dichloroacetate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516266

28 May 2018

Diabetic cardiomyopathy: insights into pathogenesis, diagnostic challenges, and therapeutic options

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516266

28 May 2018

In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516266

28 May 2018

Pyruvate dehydrogenase kinase-4 deficiency lowers blood glucose and improves glucose tolerance in diet-induced obese mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516266

28 May 2018

Effect of streptozotocin-induced diabetes on left ventricular function in adult rats: an in vivo Pinhole Gated SPECT study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516266

28 May 2018

Distinct structural mechanisms for inhibition of pyruvate dehydrogenase kinase isoforms by AZD7545, dichloroacetate, and radicicol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516266

28 May 2018

The failing heart--an engine out of fuel

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516266

28 May 2018

Role of pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) in glucose homoeostasis during starvation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516266

28 May 2018

Diagnosis and early management of inborn errors of metabolism presenting around the time of birth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516266

28 May 2018

Myocardial substrate metabolism in the normal and failing heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516266

28 May 2018

Linking gene expression to function: metabolic flexibility in the normal and diseased heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516266

28 May 2018

Global prevalence of diabetes: estimates for the year 2000 and projections for 2030

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516266

28 May 2018

Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516266

28 May 2018

Diastolic dysfunction is associated with altered myocardial metabolism in asymptomatic normotensive patients with well-controlled type 2 diabetes mellitus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516266

28 May 2018

New concepts in diastolic dysfunction and diastolic heart failure: Part I: diagnosis, prognosis, and measurements of diastolic function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516266

28 May 2018

Java-based graphical user interface for the MRUI quantitation package

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516266

28 May 2018

Increased uncoupling proteins and decreased efficiency in palmitate-perfused hyperthyroid rat heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516266

28 May 2018

Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart

1 reference

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28 May 2018

Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516266

28 May 2018

Regulation of energy substrate metabolism in the diabetic heart

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516266

28 May 2018

The metabolic effects of sodium dichloroacetate in the starved rat.

1 reference

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28 May 2018

Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM.

1 reference

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28 May 2018

Mechanisms decreasing glucose oxidation in diabetes and starvation: role of lipid fuels and hormones.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516266

28 May 2018

Dichloroacetate

1 reference

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28 May 2018

Evidence for cardiomyopathy in familial diabetes mellitus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516266

28 May 2018

Metabolic Effects of Dichloroacetate in Patients with Diabetes Mellitus and Hyperlipoproteinemia

1 reference

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28 May 2018

Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts.

1 reference

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16 August 2018

Differential modulation of glucose, lactate, and pyruvate oxidation by insulin and dichloroacetate in the rat heart

1 reference

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16 August 2018

Mortality and causes of death in the WHO Multinational Study of Vascular Disease in Diabetes.

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16 August 2018

A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4516266

16 August 2018

Impaired pyruvate oxidation but normal glucose uptake in diabetic pig heart during dobutamine-induced work

1 reference

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16 August 2018

Diabetic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/25795215

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of pyruvate kinase by free fatty acids in rat heart muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/25795215

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose oxidation rates in fatty acid-perfused isolated working hearts from diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/25795215

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diabetic cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/25795215

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of free fatty acids and dichloroacetate on isolated working diabetic rat heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/25795215

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiovascular function in patients with insulin-dependent diabetes mellitus: a study using noninvasive methods

1 reference

https://pubmed.ncbi.nlm.nih.gov/25795215

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pyruvate inhibition of pyruvate dehydrogenase kinase. Effects of progressive starvation and hyperthyroidism in vivo, and of dibutyryl cyclic AMP and fatty acids in cultured cardiac myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/25795215

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of the inhibition of fatty acid oxidation on pyruvate dehydrogenase complex activity in tissues of lean and obese mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/25795215

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationship between cardiac function and substrate oxidation in hearts of diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/25795215

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular analysis of insulin resistance in isolated ventricular cardiomyocytes of obese Zucker rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/25795215

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Effects of Hypertrophy and Diabetes on Cardiac Pyruvate Dehydrogenase Activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/25795215

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diastolic dysfunction in hypertensive heart disease is associated with altered myocardial metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/25795215

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/25795215

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ANG II causes insulin resistance and induces cardiac metabolic switch and inefficiency: a critical role of PDK4

1 reference

https://pubmed.ncbi.nlm.nih.gov/25795215

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2337/DB14-1560

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25795215%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25795215%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25795215%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

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