Role of pyruvate dehydrogenase inhibition in the development of hypertrophy in the hyperthyroid rat heart: a combined magnetic resonance imaging and hyperpolarized magnetic resonance spectroscopy study. (Q36168620)

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English	Role of pyruvate dehydrogenase inhibition in the development of hypertrophy in the hyperthyroid rat heart: a combined magnetic resonance imaging and hyperpolarized magnetic resonance spectroscopy study.	scientific article

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1 February 2020

Role of pyruvate dehydrogenase inhibition in the development of hypertrophy in the hyperthyroid rat heart: a combined magnetic resonance imaging and hyperpolarized magnetic resonance spectroscopy study (English)

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Damian J. Tyler

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George K. Radda

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George K Radda

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Helen J Atherton

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Lisa C Heather

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Marie A Schroeder

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Julian L Griffin

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Kieran Clarke

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23 May 2011

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2552-2561

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Insulin action in hyperthyroidism: a focus on muscle and adipose tissue

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Regulation of pyruvate dehydrogenase kinase 4 (PDK4) by thyroid hormone: role of the peroxisome proliferator-activated receptor gamma coactivator (PGC-1 alpha)

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Kinetic modeling of hyperpolarized 13C1-pyruvate metabolism in normal rats and TRAMP mice

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Substrate-enzyme competition attenuates upregulated anaplerotic flux through malic enzyme in hypertrophied rat heart and restores triacylglyceride content: attenuating upregulated anaplerosis in hypertrophy

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Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR.

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1 October 2017

Influence of the Thyroid State on the Intrinsic Contractile Properties and Energy Stores of the Myocardium*

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Dichloroacetate inhibits glycolysis and augments insulin-stimulated glycogen synthesis in rat muscle

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Fuel selection in animals

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Regulation of pyruvate dehydrogenase in rat heart. Mechanism of regulation of proportions of dephosphorylated and phosphorylated enzyme by oxidation of fatty acids and ketone bodies and of effects of diabetes: role of coenzyme A, acetyl-coenzyme A a

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Stimulation of phosphorylation and inactivation of pyruvate dehydrogenase by physiological inhibitors of the pyruvate dehydrogenase reaction

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Validation of the in vivo assessment of pyruvate dehydrogenase activity using hyperpolarised 13C MRS.

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Evaluation of the role of peroxisome-proliferator-activated receptor alpha in the regulation of cardiac pyruvate dehydrogenase kinase 4 protein expression in response to starvation, high-fat feeding and hyperthyroidism

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Hyperthyroidism facilitates cardiac fatty acid oxidation through altered regulation of cardiac carnitine palmitoyltransferase: studies in vivo and with cardiac myocytes

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A combined 1H-NMR spectroscopy- and mass spectrometry-based metabolomic study of the PPAR-alpha null mutant mouse defines profound systemic changes in metabolism linked to the metabolic syndrome

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Storage and oxidation of long-chain fatty acids in the C57/BL6 mouse heart as measured by NMR spectroscopy

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Residues and metabolism of 19-nortestosterone laurate in steers

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A mutant thyroid hormone receptor alpha antagonizes peroxisome proliferator-activated receptor alpha signaling in vivo and impairs fatty acid oxidation

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Faster protein and ribosome synthesis in thyroxine-induced hypertrophy of rat heart

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CINE-MR imaging of the normal and infarcted rat heart using an 11.7 T vertical bore MR system

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Long-term regulation of pyruvate dehydrogenase kinase by high-fat feeding. Experiments in vivo and in cultured cardiomyocytes

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Interactive effects of insulin and triiodothyronine on pyruvate dehydrogenase kinase activity in cardiac myocytes

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In vivo NMR investigation of intramuscular glucose metabolism in conscious rats

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The Effects of Hypertrophy and Diabetes on Cardiac Pyruvate Dehydrogenase Activity

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10.1161/CIRCULATIONAHA.110.011387

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