Tumor Suppressor WWOX inhibits osteosarcoma metastasis by modulating RUNX2 function (Q41991686)

14 October 2017

Tumor Suppressor WWOX inhibits osteosarcoma metastasis by modulating RUNX2 function (English)

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14 October 2017

Sara Del Mare

1 reference

14 October 2017

Rami I Aqeilan

series ordinal

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14 October 2017

language of work or name

English

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publication date

10 August 2015

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14 October 2017

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14 October 2017

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14 October 2017

12959

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Creative Commons Attribution 4.0 International

14 October 2017

start time

10 August 2015

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April 2022 Public Data File from Crossref

copyrighted

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describes a project that uses

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4542681/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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WWOX: a fragile tumor suppressor

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A novel whole exon deletion in WWOX gene causes early epilepsy, intellectual disability and optic atrophy

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The supposed tumor suppressor gene WWOX is mutated in an early lethal microcephaly syndrome with epilepsy, growth retardation and retinal degeneration

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The tumour suppressor gene WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation

5 June 2018

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Correlation of WWOX, RUNX2 and VEGFA protein expression in human osteosarcoma

5 June 2018

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Conditional inactivation of the mouse Wwox tumor suppressor gene recapitulates the null phenotype

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A WWOX-binding molecule, transmembrane protein 207, is related to the invasiveness of gastric signet-ring cell carcinoma

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Genomic promoter occupancy of runt-related transcription factor RUNX2 in Osteosarcoma cells identifies genes involved in cell adhesion and motility

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Wwox inactivation enhances mammary tumorigenesis

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Molecular alterations as target for therapy in metastatic osteosarcoma: a review of literature

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Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression

5 June 2018

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Runx2 regulates survivin expression in prostate cancer cells

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Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesions

5 June 2018

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5 June 2018

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WWOX gene expression abolishes ovarian cancer tumorigenicity in vivo and decreases attachment to fibronectin via integrin alpha3.

5 June 2018

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The osteogenic transcription factor runx2 controls genes involved in sterol/steroid metabolism, including CYP11A1 in osteoblasts

5 June 2018

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Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors

5 June 2018

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The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism

5 June 2018

1 reference

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Role of the WWOX gene, encompassing fragile region FRA16D, in suppression of pancreatic carcinoma cells.

5 June 2018

1 reference

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WWOX hypomorphic mice display a higher incidence of B-cell lymphomas and develop testicular atrophy.

5 June 2018

1 reference

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Wwox suppresses prostate cancer cell growth through modulation of ErbB2-mediated androgen receptor signaling

5 June 2018

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Metastasis: recent discoveries and novel treatment strategies

5 June 2018

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Targeted deletion of Wwox reveals a tumor suppressor function

5 June 2018

1 reference

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Mitotic occupancy and lineage-specific transcriptional control of rRNA genes by Runx2.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4542681

Inhibition of breast cancer cell growth in vitro and in vivo: effect of restoration of Wwox expression

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4542681

Regulatory roles of Runx2 in metastatic tumor and cancer cell interactions with bone.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4542681

WWOX gene restoration prevents lung cancer growth in vitro and in vivo

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4542681

The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4542681

Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4542681

Fidelity of Runx2 activity in breast cancer cells is required for the generation of metastases-associated osteolytic disease.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4542681

Tissue specific regulation of VEGF expression during bone development requires Cbfa1/Runx2.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4542681

Metastases detected at the time of diagnosis of primary pediatric extremity osteosarcoma at diagnosis: imaging features

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4542681

The WHO classification of bone tumors

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4542681

Association study of a functional copy number variation in the WWOX gene with risk of gliomas among Chinese people.

5 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4542681

The polymorphisms and haplotypes of WWOX gene are associated with the risk of lung cancer in southern and eastern Chinese populations

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4542681

Inactivation of the Wwox gene accelerates forestomach tumor progression in vivo

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4542681

Primary metastatic osteosarcoma: presentation and outcome of patients treated on neoadjuvant Cooperative Osteosarcoma Study Group protocols

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4542681

High grade osteosarcoma of the extremities with lung metastases at presentation: treatment with neoadjuvant chemotherapy and simultaneous resection of primary and metastatic lesions

18 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4542681

Combined modality treatment of adult soft tissue sarcomas of the head and neck

3 November 2018

1 reference

12 December 2020

Evidence of molecular alterations in the tumour suppressor gene WWOX in benign and malignant bone related lesions of the jaws

1 reference

12 December 2020

A functional copy number variation in the WWOX gene is associated with lung cancer risk in Chinese

1 reference

12 December 2020

Regulation of MMP-13 expression by RUNX2 and FGF2 in osteoarthritic cartilage

1 reference

12 December 2020

Deletion of the WWOX gene and frequent loss of its protein expression in human osteosarcoma

1 reference

12 December 2020

Identifiers

DOI

10.1038/SREP12959

1 reference

14 October 2017

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14 October 2017

PubMed publication ID

26256646

1 reference