WWOX, the chromosomal fragile site FRA16D spanning gene: its role in metabolism and contribution to cancer (Q28080638)

title

WWOX, the chromosomal fragile site FRA16D spanning gene: its role in metabolism and contribution to cancer (English)

1 reference

1 reference

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31 May 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25595186%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Robert I Richards

1 reference

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31 May 2020

Cheng Shoou Lee

series ordinal

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25595186%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Louise O'Keefe

series ordinal

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31 May 2020

language of work or name

1 reference

March 2015

1 reference

Experimental Biology and Medicine

published in

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31 May 2020

volume

240

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31 May 2020

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31 May 2020

page(s)

338-344

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Hallmarks of Cancer: The Next Generation

31 May 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935231

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935231

Medium- and short-chain dehydrogenase/reductase gene and protein families : the SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935231

Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935231

Targeted deletion of Wwox reveals a tumor suppressor function

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935231

WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935231

WWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcome

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935231

Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935231

WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935231

WWOX, the FRA16D gene, behaves as a suppressor of tumor growth

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935231

Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935231

THE METABOLISM OF TUMORS IN THE BODY

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935231

Association of reactive oxygen species levels and radioresistance in cancer stem cells

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935231

Tumor cell metabolism: cancer's Achilles' heel

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935231

Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935231

The supposed tumor suppressor gene WWOX is mutated in an early lethal microcephaly syndrome with epilepsy, growth retardation and retinal degeneration

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935231

The tumour suppressor gene WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935231

A multi-exon deletion within WWOX is associated with a 46,XY disorder of sex development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935231

Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935231

Drosophila orthologue of WWOX, the chromosomal fragile site FRA16D tumour suppressor gene, functions in aerobic metabolism and regulates reactive oxygen species

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935231

Signatures of mutation and selection in the cancer genome

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935231

Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935231

Targeted ablation of the WW domain-containing oxidoreductase tumor suppressor leads to impaired steroidogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935231

Association of Wwox with ErbB4 in breast cancer.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935231

WWOX hypomorphic mice display a higher incidence of B-cell lymphomas and develop testicular atrophy.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935231

Mechanisms of common fragile site instability.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935231

Fragile and unstable chromosomes in cancer: causes and consequences

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935231

Chromosomal fragile site FRA16D and DNA instability in cancer

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935231

The prognostic significance of WWOX expression in patients with breast cancer and its association with the basal-like phenotype

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935231

A spontaneous mutation of the Wwox gene and audiogenic seizures in rats with lethal dwarfism and epilepsy.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935231

Constitutive fragile sites and cancer.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935231

Alternative transcripts of the candidate tumor suppressor gene, WWOX, are expressed at high levels in human breast tumors

2 June 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370214565990

Association study of a functional copy number variation in the WWOX gene with risk of gliomas among Chinese people.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370214565990

WWOX--the FRA16D cancer gene: expression correlation with breast cancer progression and prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370214565990

Inactivation of the Wwox gene accelerates forestomach tumor progression in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370214565990

Q&A: Cancer: clues from cell metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370214565990

Common chromosomal fragile site FRA16D tumor suppressor WWOX gene expression and metabolic reprograming in cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370214565990

FRA16D common chromosomal fragile site oxido-reductase (FOR/WWOX) protects against the effects of ionizing radiation in Drosophila

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4935231

Increased fragile sites and sister chromatid exchanges in bone marrow and peripheral blood of young cigarette smokers

27 November 2018

1 reference

12 December 2020

Molecular mechanisms underlying WOX1 activation during apoptotic and stress responses

1 reference

12 December 2020

WWOX oxidoreductase--substrate and enzymatic characterization

1 reference

12 December 2020

A functional copy number variation in the WWOX gene is associated with lung cancer risk in Chinese

1 reference

12 December 2020

Common chromosomal fragile site FRA16D mutation in cancer cells

1 reference

12 December 2020

Direct correlation between FRA3B expression and cigarette smoking

1 reference

12 December 2020

Phenotypic characterization of spontaneously mutated rats showing lethal dwarfism and epilepsy

1 reference

12 December 2020

Identifiers

DOI

10.1177/1535370214565990

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25595186%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25595186%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

PubMed publication ID

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25595186%20AND%20SRC:MED&resulttype=core&format=json