WW domain-containing oxidoreductase's role in myriad cancers: clinical significance and future implications (Q38186582)

30 August 2017

title

WW domain-containing oxidoreductase's role in myriad cancers: clinical significance and future implications (English)

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30 August 2017

Aliza Gardenswartz

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30 August 2017

Rami I Aqeilan

series ordinal

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30 August 2017

publication date

7 February 2014

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Experimental Biology and Medicine

30 August 2017

published in

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30 August 2017

volume

239

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30 August 2017

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30 August 2017

page(s)

253-263

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WWOX gene and gene product: tumor suppression through specific protein interactions

30 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Common chromosomal fragile site FRA16D sequence: identification of the FOR gene spanning FRA16D and homozygous deletions and translocation breakpoints in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

The landscape of somatic copy-number alteration across human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

17beta-Estradiol upregulates and activates WOX1/WWOXv1 and WOX2/WWOXv2 in vitro: potential role in cancerous progression of breast and prostate to a premetastatic state in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

WWOX gene restoration prevents lung cancer growth in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Inhibition of breast cancer cell growth in vitro and in vivo: effect of restoration of Wwox expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

A role for the WWOX gene in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Functional and Clinical Characterization of the Putative Tumor Suppressor WWOX in Non-small Cell Lung Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

WWOX gene expression abolishes ovarian cancer tumorigenicity in vivo and decreases attachment to fibronectin via integrin alpha3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Targeted deletion of Wwox reveals a tumor suppressor function

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Wwox inactivation enhances mammary tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

WWOX hypomorphic mice display a higher incidence of B-cell lymphomas and develop testicular atrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

WWOX in biological control and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

WWOX: its genomics, partners, and functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Hallmarks of Cancer: The Next Generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Genetic alterations of the WWOX gene in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Loss of WWOX expression in gastric carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

WWOX: a candidate tumor suppressor gene involved in multiple tumor types

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Genetic and epigenetic alterations of WWOX in the development of gastric cardia adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Fragile genes as biomarkers: epigenetic control of WWOX and FHIT in lung, breast and bladder cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Association between CpG island methylation of the WWOX gene and its expression in breast cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

E3 ubiquitin ligase-mediated regulation of bone formation and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Effects of multidisciplinary team working on breast cancer survival: retrospective, comparative, interventional cohort study of 13 722 women

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

A multistage genetic association study identifies breast cancer risk loci at 10q25 and 16q24

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

The fragile genes FHIT and WWOX are inactivated coordinately in invasive breast carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Alternative transcripts of the candidate tumor suppressor gene, WWOX, are expressed at high levels in human breast tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Cancer and the FRA3B/FHIT fragile locus: it's a HIT

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Concordant loss of fragile gene expression early in breast cancer development

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Aberrant expression of DNA damage response proteins is associated with breast cancer subtype and clinical features

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Association of Wwox with ErbB4 in breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Estrogen receptor-negative breast carcinomas: a review of morphology and immunophenotypical analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Frequent loss of WWOX expression in breast cancer: correlation with estrogen receptor status

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

WWOX--the FRA16D cancer gene: expression correlation with breast cancer progression and prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

The prognostic significance of WWOX expression in patients with breast cancer and its association with the basal-like phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Wwox and Ap2gamma expression levels predict tamoxifen response

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Wwox expression may predict benefit from adjuvant tamoxifen in randomized breast cancer patients

21 January 2018

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https://api.crossref.org/works/10.1177%2F1535370213519213

21 January 2018

Global cancer statistics

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https://api.crossref.org/works/10.1177%2F1535370213519213

Wwox suppresses prostate cancer cell growth through modulation of ErbB2-mediated androgen receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Complement C1q activates tumor suppressor WWOX to induce apoptosis in prostate cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Integration of high-resolution array comparative genomic hybridization analysis of chromosome 16q with expression array data refines common regions of loss at 16q23-qter and identifies underlying candidate tumor suppressor genes in prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Genome-wide linkage scan for prostate cancer susceptibility from the University of Michigan Prostate Cancer Genetics Project: suggestive evidence for linkage at 16q23.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Copy number alterations in prostate tumors and disease aggressiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Deletion and mutation of WWOX exons 6-8 in human non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

WWOX gene may contribute to progression of non-small-cell lung cancer (NSCLC).

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Bmi1 regulates cell fate via tumor suppressor WWOX repression in small-cell lung cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Bone Lesions: Benign and Malignant

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Elevated expression of Runx2 as a key parameter in the etiology of osteosarcoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Conditional survival in patients with pancreatic ductal adenocarcinoma resected with curative intent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

The tumor suppressor gene WWOX at FRA16D is involved in pancreatic carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Role of the WWOX gene, encompassing fragile region FRA16D, in suppression of pancreatic carcinoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Coordinate loss of fragile gene expression in pancreatobiliary cancers: correlations among markers and clinical features

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Hypermethylation-mediated reduction of WWOX expression in intraductal papillary mucinous neoplasms of the pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Loss of WW domain-containing oxidoreductase expression in the progression and development of gastric carcinoma: clinical and histopathologic correlations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

A WWOX-binding molecule, transmembrane protein 207, is related to the invasiveness of gastric signet-ring cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Inactivation of the Wwox gene accelerates forestomach tumor progression in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

WWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Cloning of WWOX gene and its growth-inhibiting effects on ovarian cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Aberrant expression of WWOX protein in epithelial ovarian cancer: a clinicopathologic and immunohistochemical study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

WWOX tumour suppressor gene polymorphisms and ovarian cancer pathology and prognosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

WOX1 is essential for UVB irradiation-induced apoptosis and down-regulated via translational blockade in UVB-induced cutaneous squamous cell carcinoma in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

WWOX suppresses autophagy for inducing apoptosis in methotrexate-treated human squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Integrated genomic characterization of endometrial carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

The JNK inhibitor SP600129 enhances apoptosis of HCC cells induced by the tumor suppressor WWOX.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

WWOX induces apoptosis and inhibits proliferation of human hepatoma cell line SMMC-7721.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Genetic alterations of WWOX in Wilms' tumor are involved in its carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

WWOX expression in colorectal cancer—a real-time quantitative RT-PCR study

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Study of FHIT and WWOX expression in mucoepidermoid carcinoma and adenoid cystic carcinoma of salivary gland

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Molecular analysis of WWOX expression correlation with proliferation and apoptosis in glioblastoma multiforme

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Overexpression of WW domain-containing oxidoreductase WOX1 preferentially induces apoptosis in human glioblastoma cells harboring mutant p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

Gene mapping and expression analysis of 16q loss of heterozygosity identifies WWOX and CYLD as being important in determining clinical outcome in multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

WWOX Expression in Different Histologic Types and Subtypes of Non-Small Cell Lung Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213519213

21 January 2018

Identifiers

DOI

10.1177/1535370213519213

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30 August 2017

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