The adverse outcome pathway for rodent liver tumor promotion by sustained activation of the aryl hydrocarbon receptor

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exposure of normal human dermal fibroblasts results in AhR-dependent and -independent changes in gene expression.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Liver stem cells: implications for hepatocarcinogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

2,3,7,8-tetrachlorodibenzo-p-dioxin counteracts the p53 response to a genotoxicant by upregulating expression of the metastasis marker agr2 in the hepatocarcinoma cell line HepG2.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Regional hepatic CYP1A1 and CYP1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin evaluated with a multicompartment geometric model of hepatic zonation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Dose-response approaches for nuclear receptor-mediated modes of action for liver carcinogenicity: Results of a workshop

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Aryl hydrocarbon receptor-mediated disruption of contact inhibition is associated with connexin43 downregulation and inhibition of gap junctional intercellular communication

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Aryl hydrocarbon receptor-mediated induction of Stearoyl-CoA desaturase 1 alters hepatic fatty acid composition in TCDD-elicited steatosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Altered function, localization and phosphorylation of gap junctions in rat liver epithelial, IAR 20, cells after treatment with PCBs or TCDD

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Attenuation of multi-targeted proliferation-linked signaling by 3,3′-diindolylmethane (DIM): From bench to clinic

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Increasing Scientific Confidence in Adverse Outcome Pathways: Application of Tailored Bradford-Hill Considerations for Evaluating Weight of Evidence

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

The aryl hydrocarbon receptor complex and the control of gene expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

From single cells to deep phenotypes in cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Ten-year mortality study of the population involved in the Seveso incident in 1976.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Cross-species comparisons of transcriptomic alterations in human and rat primary hepatocytes exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Ah receptor- and TCDD-mediated liver tumor promotion: clonal selection and expansion of cells evading growth arrest and apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

IPCS framework for analyzing the relevance of a cancer mode of action for humans.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Application of key events analysis to chemical carcinogens and noncarcinogens

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

IPCS framework for analyzing the relevance of a noncancer mode of action for humans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Dioxin-dependent and dioxin-independent gene batteries: comparison of liver and kidney in AHR-null mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Dioxin-responsive AHRE-II gene battery: identification by phylogenetic footprinting

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Hepatic transcriptomic responses to TCDD in dioxin-sensitive and dioxin-resistant rats during the onset of toxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Temporal and dose-dependent hepatic gene expression patterns in mice provide new insights into TCDD-Mediated hepatotoxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Comparative toxicogenomic analysis of the hepatotoxic effects of TCDD in Sprague Dawley rats and C57BL/6 mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

The effect of aryl hydrocarbon receptor ligands on the expression of polymerase (DNA directed) kappa (Polκ), polymerase RNA II (DNA directed) polypeptide A (PolR2a), CYP1B1 and CYP1A1 genes in rat liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

The constitutively active Ah receptor (CA-Ahr) mouse as a potential model for dioxin exposure--effects in vital organs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Effects of 2,3,7,8-tetrachloro- and 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin on the proliferation of preneoplastic liver cells in the rat

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Human and rat primary hepatocyte CYP1A1 and 1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, and 2,3,4,7,8-pentachlorodibenzofuran.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Mode of action and dose-response framework analysis for receptor-mediated toxicity: The aryl hydrocarbon receptor as a case study.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Hepatic and gastrointestinal effects in an occupational cohort exposed to 2,3,7,8-tetrachlorodibenzo-para-dioxin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Divergent transcriptomic responses to aryl hydrocarbon receptor agonists between rat and human primary hepatocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Using mode of action information to improve regulatory decision-making: an ECETOC/ILSI RF/HESI workshop overview.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

A histochemical and pathological study on the interrelationship between TCDD-induced AhR expression, AhR activation, and hepatotoxicity in mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Stem cell genome‐to‐systems biology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Inhibition of UV-C light-induced apoptosis in liver cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Inhibition of apoptosis by 2,3,7,8-tetrachlorodibenzo-p-dioxin depends on protein biosynthesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Dioxin toxicity, aryl hydrocarbon receptor signaling, and apoptosis—Persistent pollutants affect programmed cell death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Blood lipid concentrations of dioxins and dibenzofurans causing chloracne

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Cell proliferation in carcinogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Evaluating the human relevance of chemically induced animal tumors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

The human relevance of information on carcinogenic modes of action: overview

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

7 January 2021

Chemical carcinogenesis

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Mortality rates among trichlorophenol workers with exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Mortality rates among workers exposed to dioxins in the manufacture of pentachlorophenol

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

AH receptor agonist activity in human blood measured with a cell-based bioassay: evidence for naturally occurring AH receptor ligands in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Human response to dioxin: aryl hydrocarbon receptor (AhR) molecular structure, function, and dose-response data for enzyme induction indicate an impaired human AhR.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Hepatic Foci in Rats after Diethylnitrosamine Initiation and 2,3,7,8-Tetrachlorodibenzo-p-dioxin Promotion: Evaluation of a Quantitative Two-Cell Model and of CYP 1A1/1A2 as a Dosimeter

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Developing scientific confidence in HTS-derived prediction models: lessons learned from an endocrine case study.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Mode of action: moving toward a more relevant and efficient assessment paradigm

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Exactly the Same but Different: Promiscuity and Diversity in the Molecular Mechanisms of Action of the Aryl Hydrocarbon (Dioxin) Receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Differences in TCDD-elicited gene expression profiles in human HepG2, mouse Hepa1c1c7 and rat H4IIE hepatoma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

2,3,7,8-tetrachlorodibenzo-p-dioxin-dependent release from contact inhibition in WB-F344 cells: involvement of cyclin A.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

The aryl hydrocarbon receptor (AhR) in the regulation of cell-cell contact and tumor growth.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Animal studies addressing the carcinogenicity of TCDD (or related compounds) with an emphasis on tumour promotion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Characterization of the promotion of altered hepatic foci by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the female rat

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Differentiation-specific factors modulate epidermal CYP1-4 gene expression in human skin in response to retinoic acid and classic aryl hydrocarbon receptor ligands.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Prediction of a carcinogenic potential of rat hepatocarcinogens using toxicogenomics analysis of short-term in vivo studies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Comparison of the expression profiles induced by genotoxic and nongenotoxic carcinogens in rat liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Relative potency values derived from hepatic vitamin A reduction in male and female Sprague-Dawley rats following subchronic dietary exposure to individual polychlorinated dibenzo-p-dioxin and dibenzofuran congeners and a mixture thereof

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Application of the International Life Sciences Institute Key Events Dose-Response Framework to food contaminants

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Development and Evaluation of a Genomic Signature for the Prediction and Mechanistic Assessment of Nongenotoxic Hepatocarcinogens in the Rat

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

A gene expression biomarker provides early prediction and mechanistic assessment of hepatic tumor induction by nongenotoxic chemicals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Differential gene regulation by the human and mouse aryl hydrocarbon receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Hepatic vitamin a depletion is a sensitive marker of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure in four rodent species

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters the mRNA expression of critical genes associated with cholesterol metabolism, bile acid biosynthesis, and bile transport in rat liver: a microarray study

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Effects of TCDD on the expression of nuclear encoded mitochondrial genes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Induction of a chloracne phenotype in an epidermal equivalent model by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is dependent on aryl hydrocarbon receptor activation and is not reproduced by aryl hydrocarbon receptor knock down.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Patterns of dioxin-altered mRNA expression in livers of dioxin-sensitive versus dioxin-resistant rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

The pleiotropy of dioxin toxicity--xenobiotic misappropriation of the aryl hydrocarbon receptor's alternative physiological roles.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Expression and activity of aryl hydrocarbon receptors in development and cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Transcription factor interactions in genomic nuclear receptor function.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: clinical and laboratory effects

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

2,3,7,8-tetrachlorodibenzo-p-dioxin impairs differentiation of normal human epidermal keratinocytes in a skin equivalent model

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Hepatotoxicity and carcinogenicity in female Sprague-Dawley rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): a pathology working group reevaluation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Increases in cytochrome P-450 mediated 17 beta-estradiol 2-hydroxylase activity in rat liver microsomes after both acute administration and subchronic administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin in a two-stage hepatocarcinogenesis model.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Does dioxin exert toxic effects in humans at or near current background body levels?: An evidence-based conclusion.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Classification of proliferative hepatocellular lesions in harlan sprague-dawley rats chronically exposed to dioxin-like compounds.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

The distribution of [14C]-2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and its effect on the vitamin A content in parenchymal and stellate cells of rat liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Hallmarks of Cancer: The Next Generation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Repression of aryl hydrocarbon receptor transcriptional activity by epidermal growth factor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Analysis of the transcriptional regulation and molecular function of the aryl hydrocarbon receptor repressor in human cell lines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

In vitro - in vivo correlation of gene expression alterations induced by liver carcinogens.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Indolo[3,2-b]carbazole inhibits gap junctional intercellular communication in rat primary hepatocytes and acts as a potential tumor promoter

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Catechol estrogens induce oxidative DNA damage and estradiol enhances cell proliferation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Retinoid status and responsiveness to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking retinoid binding protein or retinoid receptor forms.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Ginsenosides are novel naturally-occurring aryl hydrocarbon receptor ligands

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Transcription factor Nrf2/MafK regulates rat placental glutathione S-transferase gene during hepatocarcinogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Non-alcoholic steatohepatitis and hepatocellular carcinoma: implications for lycopene intervention

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

The emerging role of the Nrf2-Keap1 signaling pathway in cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Pathological changes in the liver of mice given 2,3,7,8-tetrachlorodibenzo-p-dioxin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

The Key Events Dose-Response Framework: a cross-disciplinary mode-of-action based approach to examining dose-response and thresholds

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

2,3,7,8-Tetrachlorodibenzo-p-dioxin alters sebaceous gland cell differentiation in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

2,3,7,8-Tetrachlorodibenzo-p-dioxin induced cytochrome P450s alter the formation of reactive oxygen species in liver cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Impaired preneoplastic changes and liver tumor formation in tumor necrosis factor receptor type 1 knockout mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

The Q-rich subdomain of the human Ah receptor transactivation domain is required for dioxin-mediated transcriptional activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Coregulators and chromatin remodeling in transcriptional control

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Induced CYP1A2 Activity as a Phenotypic Biomarker in Humans Highly Exposed to Certain PCBs/PCDFs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Nuclear receptors, coactivators and chromatin: new approaches, new insights

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Multiple roles of ligand in transforming the dioxin receptor to an active basic helix-loop-helix/PAS transcription factor complex with the nuclear protein Arnt

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Involvement of aryl hydrocarbon receptor in basal and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced expression of target genes in primary human hepatocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Hepatic progenitor cells in human liver tumor development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Hepatic progenitor cells in hepatocellular adenomas

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

2,3,7,8-Tetrachlorodibenzo-p-dioxin alters the differentiation pattern of human keratinocytes in organotypic culture

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on initiation and promotion of GST-P-positive foci in rat liver: A quantitative analysis of experimental data using a stochastic model

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Nrf2 protects against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced oxidative injury and steatohepatitis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Influence of light on aryl hydrocarbon receptor signaling and consequences in drug metabolism, physiology and disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

TCDD-inducible poly (ADP-ribose) polmerase: a novel response to 2,3,7,8-tetrachlorodibenzo-p-dioxin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Estrogen receptor and aryl hydrocarbon receptor signaling pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Aryl hydrocarbon receptor-mediated transcription: ligand-dependent recruitment of estrogen receptor alpha to 2,3,7,8-tetrachlorodibenzo-p-dioxin-responsive promoters

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Mortality in workers exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin at a trichlorophenol plant in New Zealand

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Recent developments in frameworks to consider human relevance of hypothesized modes of action for tumours in animals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

A framework for fit-for-purpose dose response assessment

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

A framework for human relevance analysis of information on carcinogenic modes of action

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Mode of action human relevance (species concordance) framework: Evolution of the Bradford Hill considerations and comparative analysis of weight of evidence

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

New developments in the evolution and application of the WHO/IPCS framework on mode of action/species concordance analysis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Clinical laboratory manifestations of exposure to dioxin in children. A six-year study of the effects of an environmental disaster near Seveso, Italy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Serum concentrations of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin and test results from selected residents of Seveso, Italy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

A constitutively active dioxin/aryl hydrocarbon receptor promotes hepatocarcinogenesis in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Aryl hydrocarbon receptor (AHR)-regulated transcriptomic changes in rats sensitive or resistant to major dioxin toxicities

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Quantitative analysis of enzyme-altered liver foci in rats initiated with diethylnitrosamine and promoted with 2,3,7,8-tetrachlorodibenzo-p-dioxin or 1,2,3,4,6,7,8-heptachlorodibenzo-p-dioxin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Cutaneous histologic findings in chemical workers with and without chloracne with past exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Lessons from mouse models of high-fat diet-induced NAFLD

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

UGT1A6 and UGT2B15 polymorphisms and acetaminophen conjugation in response to a randomized, controlled diet of select fruits and vegetables

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Cruciferous vegetable feeding alters UGT1A1 activity: diet- and genotype-dependent changes in serum bilirubin in a controlled feeding trial

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

The search for endogenous activators of the aryl hydrocarbon receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Predictive toxicogenomics approaches reveal underlying molecular mechanisms of nongenotoxic carcinogenicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

An aryl hydrocarbon receptor odyssey to the shores of toxicology: the Deichmann Lecture, International Congress of Toxicology-XI

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Mortality After Exposure to Polychlorinated Biphenyls and Polychlorinated Dibenzofurans: A 40-Year Follow-up Study of Yusho Patients

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Hepatic gene downregulation following acute and subchronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

TCDD activates Mdm2 and attenuates the p53 response to DNA damaging agents

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Origin and structural evolution of the early proliferating oval cells in rat liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Use and validation of HT/HC assays to support 21st century toxicity evaluations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Controlling nuclear receptors: the circular logic of cofactor cycles

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

CYP1A2, GSTM1, and GSTT1 polymorphisms and diet effects on CYP1A2 activity in a crossover feeding trial

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Mechanism-based common reactivity pattern (COREPA) modelling of aryl hydrocarbon receptor binding affinity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Aryl hydrocarbon receptor-dependent induction of liver fibrosis by dioxin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Hepatic stellate cells' involvement in progenitor-mediated liver regeneration

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Human health effects from accidental release of tetrachlorodibenzo-p-dioxin (TCDD) at Seveso, Italy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Differential effects of indirubin and 2,3,7,8-tetrachlorodibenzo-p-dioxin on the aryl hydrocarbon receptor (AhR) signalling in liver progenitor cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

The interplay of the aryl hydrocarbon receptor and β-catenin alters both AhR-dependent transcription and Wnt/β-catenin signaling in liver progenitors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on I-compounds in hepatic DNA of Sprague-Dawley rats: sex-specific effects and structure-activity relationships

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

The subdomains of the transactivation domain of the aryl hydrocarbon receptor (AhR) inhibit AhR and estrogen receptor transcriptional activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Acute human exposure to TCDD in Seveso, Italy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Perturbation of the mitosis/apoptosis balance: a fundamental mechanism in toxicology.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Transcriptional profiles induced by the Aryl Hydrocarbon Receptor agonists 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran and 2,3,4,7,8-pentachlorodibenzofuran in primary rat hepatocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Isolation and characterization of a novel population of progenitor cells from unmanipulated rat liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Identification of a critical dose level for risk assessment: developments in benchmark dose analysis of continuous endpoints

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

The aryl hydrocarbon receptor and glucocorticoid receptor interact to activate human metallothionein 2A.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

The Cutaneous Lesions of Dioxin Exposure: Lessons from the Poisoning of Victor Yushchenko

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Chloracne, a misnomer and its implications

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters the endogenous metabolism of all-trans-retinoic acid in the rat.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Promotion of preneoplastic foci in rat liver with 2,3,7,8-tetrachlorodibenzo-p-dioxin, 1,2,3,4,6,7,8-heptachloro-dibenzo-p-dioxin and a defined mixture of 49 polychlorinated dibenzo-p-dioxins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Tumor promoters as inhibitors of apoptosis in rat hepatocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Ah receptor ligands and tumor promotion: survival of neoplastic cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Overview: Using mode of action and life stage information to evaluate the human relevance of animal toxicity data

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Hepatic stellate cell (vitamin A-storing cell) and its relative--past, present and future

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

The transcription factor NF-E2-related factor 2 (Nrf2): a protooncogene?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Comparison of TCDD and PCB CYP1A induction sensitivities in fresh hepatocytes from human donors, sprague-dawley rats, and rhesus monkeys and HepG2 cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Estimates of cancer potency of 2,3,7,8-tetrachlorodibenzo(p)dioxin using linear and nonlinear dose-response modeling and toxicokinetics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

The use of mode of action information in risk assessment: quantitative key events/dose-response framework for modeling the dose-response for key events

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

A biomonitoring framework to support exposure and risk assessments.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

IPCS conceptual framework for evaluating a mode of action for chemical carcinogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

AhR signalling and dioxin toxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Ligand Displaces Heat Shock Protein 90 from Overlapping Binding Sites within the Aryl Hydrocarbon Receptor Ligand-binding Domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Inhibition of apoptosis during 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated tumour promotion in rat liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

2,3,7,8-Tetrachlorodibenzo-p-dioxin Increases the Expression of Genes in the Human Epidermal Differentiation Complex and Accelerates Epidermal Barrier Formation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Analysis of the CYP1A1 mRNA Dose-Response in Human Keratinocytes Indicates that Relative Potencies of Dioxins, Furans, and PCBs Are Species and Congener Specific

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

EGF receptor signaling blocks aryl hydrocarbon receptor-mediated transcription and cell differentiation in human epidermal keratinocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Liver stem/progenitor cells: their characteristics and regulatory mechanisms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Inhibitory effect of sinigrin and indole-3-carbinol on diethylnitrosamine-induced hepatocarcinogenesis in male ACI/N rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Expression of AhR, CYP1A1, GSTA1, c-fos and TGF-alpha in skin lesions from dioxin-exposed humans with chloracne

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Quantitative analysis of dose- and time-dependent promotion of four phenotypes of altered hepatic foci by 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Sprague-Dawley rats.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Nuclear receptor recruitment of histone-modifying enzymes to target gene promoters

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Increased liver and lupus mortalities in 24-year follow-up of the Taiwanese people highly exposed to polychlorinated biphenyls and dibenzofurans

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Accelerator mass spectrometry in biomedical dosimetry: relationship between low-level exposure and covalent binding of heterocyclic amine carcinogens to DNA

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Tumor necrosis factor-alpha modulates effects of aryl hydrocarbon receptor ligands on cell proliferation and expression of cytochrome P450 enzymes in rat liver "stem-like" cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

CYP1A1 and CYP1A2 expression: comparing 'humanized' mouse lines and wild-type mice; comparing human and mouse hepatoma-derived cell lines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Comparison of supervised clustering methods to discriminate genotoxic from non-genotoxic carcinogens by gene expression profiling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Subchronic exposure to TCDD, PeCDF, PCB126, and PCB153: effect on hepatic gene expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Estrogen receptor levels and occupancy in hepatic sinusoidal endothelial and Kupffer cells are enhanced by initiation with diethylnitrosamine and promotion with 17alpha-ethinylestradiol in rats.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Adverse outcome pathway (AOP) development I: strategies and principles

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Adverse outcome pathway development II: best practices.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

The role of aryl hydrocarbon receptor in regulation of enzymes involved in metabolic activation of polycyclic aromatic hydrocarbons in a model of rat liver progenitor cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Comparison of chronic toxicity and carcinogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in 2-year bioassays in female Sprague-Dawley rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

The aryl hydrocarbon receptor interacts with nuclear factor erythroid 2-related factor 2 to mediate induction of NAD(P)H:quinoneoxidoreductase 1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

The origin and liver repopulating capacity of murine oval cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Synergism between 2,3,7,8-tetrachlorodibenzo-p-dioxin and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone on lung tumor incidence in mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Discrimination of genotoxic and non-genotoxic hepatocarcinogens by statistical analysis based on gene expression profiling in the mouse liver as determined by quantitative real-time PCR.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

TCDD deregulates contact inhibition in rat liver oval cells via Ah receptor, JunD and cyclin A

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

2,3,7,8-Tetrachlorodibenzo-p-dioxin mechanistic data and risk assessment: gene regulation, cytotoxicity, enhanced cell proliferation, and tumor promotion

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Growth stimulation of primary rat hepatocytes by 2,3,7,8-tetrachlorodibenzo-p-dioxin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

2,3,7,8-Tetrachlorodibenzo-p-dioxin suppresses apoptosis and leads to hyperphosphorylation of p53 in rat hepatocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Involvement of PTEN/Akt signaling and oxidative stress on indole-3-carbinol (I3C)-induced hepatocarcinogenesis in rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Inter-strain heterogeneity in rat hepatic transcriptomic responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Keap1 eye on the target: chemoprevention of liver cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Dose response relationship in anti-stress gene regulatory networks

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015

Theoretical study of the quantitative structure-activity relationships for the toxicity of dibenzo-p-dioxins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YRTPH.2015.06.015