Application of key events analysis to chemical carcinogens and noncarcinogens (Q33736229)

29 July 2017

title

Application of key events analysis to chemical carcinogens and noncarcinogens (English)

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29 July 2017

R Julian Preston

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29 July 2017

Alan R Boobis

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29 July 2017

George P Daston

series ordinal

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29 July 2017

Stephen S Olin

series ordinal

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29 July 2017

publication date

1 September 2009

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Critical Reviews in Food Science and Nutrition

29 July 2017

published in

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29 July 2017

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29 July 2017

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29 July 2017

page(s)

690-707

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The Key Events Dose-Response Framework: a cross-disciplinary mode-of-action based approach to examining dose-response and thresholds

29 July 2017

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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DNA-reactive carcinogens: mode of action and human cancer hazard

21 June 2018

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No-threshold dose-response curves for nongenotoxic chemicals: findings and applications for risk assessment

21 June 2018

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Design of a microsphere-based high-throughput gene expression assay to determine estrogenic potential

21 June 2018

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Reduced mitochondrial membrane potential and metabolism correspond to acute chloroform toxicity of in vitro hepatocytes

21 June 2018

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Phenotypic anchoring of gene expression changes during estrogen-induced uterine growth

21 June 2018

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Repair and genetic consequences of endogenous DNA base damage in mammalian cells

21 June 2018

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Experimental cancer studies of chlorinated by-products

21 June 2018

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The metabolic rate constants and specific activity of human and rat hepatic cytochrome P-450 2E1 toward toluene and chloroform

21 June 2018

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A framework for human relevance analysis of information on carcinogenic modes of action

21 June 2018

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Human drug metabolising cytochrome P450 enzymes: properties and polymorphisms

21 June 2018

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Chloroform, carbon tetrachloride and glutathione depletion induce secondary genotoxicity in liver cells via oxidative stress

21 June 2018

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Extent and timeliness of tissue repair determines the dose-related hepatotoxicity of chloroform

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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Species differences in the hepatotoxicity of paracetamol are due to differences in the rate of conversion to its cytotoxic metabolite.

21 June 2018

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The intralobular distribution of ethanol-inducible P450IIE1 in rat and human liver

21 June 2018

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A genetic model for colorectal tumorigenesis

21 June 2018

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Genetic Polymorphisms in the 5′-Flanking Region Change Transcriptional Regulation of the Human Cytochrome P450IIE1 Gene1

21 June 2018

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Expression of CYP2E1 during human fetal development: methylation of the CYP2E1 gene in human fetal and adult liver samples

21 June 2018

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21 June 2018

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21 June 2018

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21 January 2018

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IPCS framework for analyzing the relevance of a cancer mode of action for humans.

21 January 2018

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Mechanisms of chloroform-induced hepatotoxicity: oxidative stress and mitochondrial permeability transition in freshly isolated mouse hepatocytes.

21 January 2018

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Metabolism of Chloroform by Cytochrome P450 2E1 Is Required for Induction of Toxicity in the Liver, Kidney, and Nose of Male Mice

21 January 2018

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Systems biology and mode of action based risk assessment

21 January 2018

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Identification of temporal patterns of gene expression in the uteri of immature, ovariectomized mice following exposure to ethynylestradiol

21 January 2018

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Modeling for risk assessment of neurotoxic effects

21 January 2018

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Bioactivation, toxicokinetics and acute effects of chloroform in Fisher 344 and Osborne Mendel male rats.

21 January 2018

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Gene expression profiling of rat livers reveals indicators of potential adverse effects.

21 January 2018

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Human Hepatic CYP2E1 Expression during Development

21 January 2018

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Bayesian estimation of pharmacokinetic and pharmacodynamic parameters in a mode-of-action-based cancer risk assessment for chloroform

21 January 2018

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The effects of alcohol and diallyl sulphide on CYP2E1 activity in humans: a phenotyping study using chlorzoxazone

21 January 2018

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21 January 2018

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Guidelines for application of chemical-specific adjustment factors in dose/concentration-response assessment

21 January 2018

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Betulin is a potent anti-tumor agent that is enhanced by cholesterol

21 January 2018

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Gene expression changes induced in the testis by transplacental exposure to high and low doses of 17{alpha}-ethynyl estradiol, genistein, or bisphenol A.

21 January 2018

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Inhibition of human cytochrome P450 2E1 by halogenated anilines, phenols, and thiophenols

21 January 2018

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The effect of isoniazid on CYP2E1- and CYP4A-mediated hydroxylation of arachidonic acid in the rat liver and kidney

21 January 2018

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Patterns of chloroform-induced regenerative cell proliferation in BDF1 mice correlate with organ specificity and dose-response of tumor formation

21 January 2018

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A 90-day chloroform inhalation study in F-344 rats: profile of toxicity and relevance to cancer studies

21 January 2018

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Liver parenchymal cell injury. V. Relationships between patterns of chloromethane-C 14 incorporation into constituents of liver in vivo and cellular injury

21 January 2018

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12 December 2020

Phosgene: A metabolite of chloroform

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12 December 2020

The formation of diglutathionyl dithiocarbonate as a metabolite of chloroform, bromotrichloromethane, and carbon tetrachloride

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12 December 2020

Effect of cysteine, diethyl maleate, and phenobarbital treatments on the hepatotoxicity of [1H]- and [2H]chloroform

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12 December 2020

Mechanism of chloroform nephrotoxicity. I. Time course of chloroform toxicity in male and female mice

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12 December 2020

Mechanism of chloroform nephrotoxicity. II. In vitro evidence for renal metabolism of chloroform in mice

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12 December 2020

Nephrotoxicity of chloroform: metabolism to phosgene by the mouse kidney

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12 December 2020

Strain and sex differences in chloroform-induced nephrotoxicity. Different rates of metabolism of chloroform to phosgene by the mouse kidney

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12 December 2020

Role of intrarenal biotransformation in chloroform-induced nephrotoxicity in rats

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12 December 2020

Centrilobular expression of ethanol-inducible cytochrome P-450 (IIE1) in rat liver

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12 December 2020

Induced cytotoxicity and cell proliferation in the hepatocarcinogenicity of chloroform in female B6C3F1 mice: comparison of administration by gavage in corn oil vs ad libitum in drinking water

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12 December 2020

Comparison of chloroform-induced toxicity in the kidneys, liver, and nasal passages of male Osborne-Mendel and F-344 rats

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12 December 2020

Genetic polymorphism of human CYP2E1: characterization of two variant alleles

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12 December 2020

Time courses of hepatic injuries induced by chloroform and by carbon tetrachloride: comparison of biochemical and histopathological changes

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12 December 2020

Chloroform-induced cytolethality in freshly isolated male B6C3F1 mouse and F-344 rat hepatocytes

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12 December 2020

Development of a comprehensive panel of antibodies against the major xenobiotic metabolising forms of cytochrome P450 in humans

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12 December 2020

Ex vivo and in vitro testis and ovary explants: utility for identifying steroid biosynthesis inhibitors and comparison to a Tier I screening battery

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12 December 2020

Environmental antiandrogens: low doses of the fungicide vinclozolin alter sexual differentiation of the male rat

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12 December 2020

Renal and hepatic accumulation of cadmium and lead in the expression of CYP4F2 and CYP2E1

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12 December 2020

10.1080/10408390903098673

Identifiers

DOI

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29 July 2017

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29 July 2017

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