Phosphoinositide 3-kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death (Q40068228)

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English	Phosphoinositide 3-kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

17 September 2017

Phosphoinositide 3-kinase/Akt pathway plays an important role in chemoresistance of gastric cancer cells against etoposide and doxorubicin induced cell death (English)

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Europe PubMed Central

PubMed publication ID

17 September 2017

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author name string

Hong-Gang Yu

1

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17 September 2017

Yao-Wei Ai

2

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17 September 2017

Liang-Liang Yu

3

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17 September 2017

Xiao-Dong Zhou

4

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17 September 2017

Jin Liu

5

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17 September 2017

Jun-Hua Li

6

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17 September 2017

Xi-Ming Xu

7

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17 September 2017

Song Liu

8

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17 September 2017

Jing Chen

9

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17 September 2017

Fen Liu

10

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17 September 2017

Yuan-Ling Qi

11

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17 September 2017

Quanjun Deng

12

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17 September 2017

Jun Cao

13

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17 September 2017

Shi-Quan Liu

14

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17 September 2017

He-Sheng Luo

15

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17 September 2017

Jie-Ping Yu

16

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17 September 2017

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publication date

1 January 2008

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17 September 2017

International Journal of Cancer

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17 September 2017

122

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17 September 2017

2

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17 September 2017

433-443

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17 September 2017

Long-term follow-up of a pilot phase II study with neoadjuvant epidoxorubicin, etoposide and cisplatin in gastric cancer

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https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

Histomorphology and grading of regression in gastric carcinoma treated with neoadjuvant chemotherapy

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https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

A phase II study of doxorubicin, cisplatin, and 5-fluorouracil in patients with advanced adenocarcinoma of the stomach or esophagus

1 reference

https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

Mitochondria as therapeutic targets for cancer chemotherapy

1 reference

https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy

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https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

1 reference

https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas

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https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

Molecular cloning and identification of a serine/threonine protein kinase of the second-messenger subfamily

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https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells

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https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

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https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis

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https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

Frequent monoallelic deletion of PTEN and its reciprocal associatioin with PIK3CA amplification in gastric carcinoma.

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https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

Akt phosphorylation associates with LOH of PTEN and leads to chemoresistance for gastric cancer

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https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

1 reference

https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma

1 reference

https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

Akt-and CREB-mediated prostate cancer cell proliferation inhibition by Nexrutine, a Phellodendron amurense extract

1 reference

https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

Akt kinase activation blocks apoptosis in intestinal epithelial cells by inhibiting caspase-3 after polyamine depletion

1 reference

https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer

1 reference

https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

PED mediates AKT-dependent chemoresistance in human breast cancer cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation

1 reference

https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

The promoter of human p22/PACAP response gene 1 (PRG1) contains functional binding sites for the p53 tumor suppressor and for NFkappaB.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity

1 reference

https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

1 reference

https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

The survival kinases Akt and Pim as potential pharmacological targets

1 reference

https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

COX-2 inhibitor, NS398, enhances Fas-mediated apoptosis via modulation of the PTEN-Akt pathway in human gastric carcinoma cell lines

1 reference

https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction

1 reference

https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

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https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

Internalin B activates nuclear factor-kappa B via Ras, phosphoinositide 3-kinase, and Akt.

1 reference

https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

Nuclear factor-kappaB in cancer development and progression

1 reference

https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

Rho/Rhotekin-mediated NF-kappaB activation confers resistance to apoptosis

1 reference

https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

Tumor stroma interactions induce chemoresistance in pancreatic ductal carcinoma cells involving increased secretion and paracrine effects of nitric oxide and interleukin-1beta

1 reference

https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

Inducible nuclear factor-kappaB activation contributes to chemotherapy resistance in gastric cancer

1 reference

https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

Kinase regulation in inflammatory response

1 reference

https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

1 reference

https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)

1 reference

https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

Forkhead transcription factors contribute to execution of the mitotic programme in mammals

1 reference

https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

Inhibition of the PI3K-Akt signaling pathway enhances the sensitivity of Fas-mediated apoptosis in human gastric carcinoma cell line, MKN-45

1 reference

https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

1 reference

https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

Alterations of tumor suppressor and tumor-related genes in the development and progression of gastric cancer

1 reference

https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

Role and regulation of activation of caspases in cisplatin-induced injury to renal tubular epithelial cells

1 reference

https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

Regulation of cell death protease caspase-9 by phosphorylation

1 reference

https://api.crossref.org/works/10.1002%2FIJC.23049

21 January 2018

Identifiers

10.1002/IJC.23049

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

17 September 2017

ResearchGate publication ID

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