HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation (Q40767550)

23 September 2017

title

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation (English)

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23 September 2017

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protein ubiquitination

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B P Zhou

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23 September 2017

Y Liao

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23 September 2017

W Xia

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23 September 2017

Y Zou

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23 September 2017

B Spohn

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23 September 2017

M C Hung

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23 September 2017

publication date

1 November 2001

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23 September 2017

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23 September 2017

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23 September 2017

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23 September 2017

page(s)

973-982

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Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

23 September 2017

cites work

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https://api.crossref.org/works/10.1038%2FNCB1101-973

7 January 2021

Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer

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https://api.crossref.org/works/10.1038%2FNCB1101-973

7 January 2021

HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathway

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-973

7 January 2021

Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-973

7 January 2021

Mechanisms and consequences of activation of protein kinase B/Akt

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https://api.crossref.org/works/10.1038%2FNCB1101-973

7 January 2021

Cellular survival: a play in three Akts

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https://api.crossref.org/works/10.1038%2FNCB1101-973

7 January 2021

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

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https://api.crossref.org/works/10.1038%2FNCB1101-973

7 January 2021

Regulation of cell death protease caspase-9 by phosphorylation

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https://api.crossref.org/works/10.1038%2FNCB1101-973

7 January 2021

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

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https://api.crossref.org/works/10.1038%2FNCB1101-973

7 January 2021

Direct control of the Forkhead transcription factor AFX by protein kinase B

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https://api.crossref.org/works/10.1038%2FNCB1101-973

7 January 2021

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-973

7 January 2021

Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53-mediated, transcriptionally dependent apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-973

7 January 2021

Regulation of p53 function

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https://api.crossref.org/works/10.1038%2FNCB1101-973

7 January 2021

https://api.crossref.org/works/10.1038%2FNCB1101-973

1 reference

7 January 2021

https://api.crossref.org/works/10.1038%2FNCB1101-973

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7 January 2021

Surfing the p53 network

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https://api.crossref.org/works/10.1038%2FNCB1101-973

7 January 2021

Strategies for manipulating the p53 pathway in the treatment of human cancer.

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https://api.crossref.org/works/10.1038%2FNCB1101-973

7 January 2021

Checkpoints: How to activate p53

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https://api.crossref.org/works/10.1038%2FNCB1101-973

7 January 2021

MDM2--master regulator of the p53 tumor suppressor protein

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https://api.crossref.org/works/10.1038%2FNCB1101-973

7 January 2021

Regulation of p53 stability and activity in response to genotoxic stress.

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https://api.crossref.org/works/10.1038%2FNCB1101-973

7 January 2021

Binding and modulation of p53 by p300/CBP coactivators

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https://api.crossref.org/works/10.1038%2FNCB1101-973

7 January 2021

p300/MDM2 complexes participate in MDM2-mediated p53 degradation

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https://api.crossref.org/works/10.1038%2FNCB1101-973

7 January 2021

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-973

7 January 2021

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-973

7 January 2021

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

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https://api.crossref.org/works/10.1038%2FNCB1101-973

7 January 2021

Nucleolar Arf sequesters Mdm2 and activates p53

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https://api.crossref.org/works/10.1038%2FNCB1101-973

7 January 2021

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-973

7 January 2021

Enhanced chemoresistance by elevation of p185neu levels in HER-2/neu-transfected human lung cancer cells.

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-973

7 January 2021

The DNA damage response: putting checkpoints in perspective

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-973

7 January 2021

Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-973

7 January 2021

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-973

7 January 2021

Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus.

1 reference

https://api.crossref.org/works/10.1038%2FNCB1101-973

7 January 2021

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

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https://api.crossref.org/works/10.1038%2FNCB1101-973

7 January 2021

Identifiers

DOI

10.1038/NCB1101-973

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23 September 2017

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