The phosphatidylinositol 3-Kinase AKT pathway in human cancer (Q29547860)

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10 November 2019

review article

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title

The phosphatidylinositol 3-Kinase AKT pathway in human cancer (English)

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PubMed

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10 November 2019

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10 November 2019

Charles L Sawyers

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10 November 2019

language of work or name

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23 April 2017

publication date

1 July 2002

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10 November 2019

published in

Nature Reviews Cancer

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10 November 2019

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23 April 2017

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10 November 2019

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10 November 2019

page(s)

489-501

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Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

10 November 2019

cites work

1 reference

The IRS-signalling system: a network of docking proteins that mediate insulin action

31 March 2020

1 reference

p85alpha gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-Kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin

31 March 2020

1 reference

Insulin-like growth factors require phosphatidylinositol 3-kinase to signal myogenesis: dominant negative p85 expression blocks differentiation of L6E9 muscle cells

31 March 2020

1 reference

Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85alpha regulatory subunit

31 March 2020

1 reference

Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit

31 March 2020

1 reference

Phosphatidylinositol-3-OH kinase as a direct target of Ras

31 March 2020

1 reference

The activation of phosphatidylinositol 3-kinase by Ras

31 March 2020

1 reference

Tyrosine phosphorylation of p85 relieves its inhibitory activity on phosphatidylinositol 3-kinase

31 March 2020

1 reference

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

31 March 2020

1 reference

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

31 March 2020

1 reference

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

31 March 2020

1 reference

Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.

31 March 2020

1 reference

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

31 March 2020

1 reference

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

31 March 2020

1 reference

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

31 March 2020

1 reference

Shc and FAK differentially regulate cell motility and directionality modulated by PTEN.

31 March 2020

1 reference

Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

31 March 2020

1 reference

Phosphatidylinositol (3,4,5)P3 is essential but not sufficient for protein kinase B (PKB) activation; phosphatidylinositol (3,4)P2 is required for PKB phosphorylation at Ser-473: studies using cells from SH2-containing inositol-5-phosphatase knockou

31 March 2020

1 reference

SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival

31 March 2020

1 reference

Cellular survival: a play in three Akts

31 March 2020

1 reference

PKB/AKT: functional insights from genetic models

31 March 2020

1 reference

Role of translocation in the activation and function of protein kinase B

31 March 2020

1 reference

Akt activation by growth factors is a multiple-step process: the role of the PH domain

31 March 2020

1 reference

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

31 March 2020

1 reference

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

31 March 2020

1 reference

Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

31 March 2020

1 reference

The protooncogene TCL1 is an Akt kinase coactivator

31 March 2020

1 reference

Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors

31 March 2020

1 reference

Carboxyl-terminal modulator protein (CTMP), a negative regulator of PKB/Akt and v-Akt at the plasma membrane

31 March 2020

1 reference

Modulation of Akt kinase activity by binding to Hsp90

31 March 2020

1 reference

Regulation of neuronal survival by the serine-threonine protein kinase Akt

31 March 2020

1 reference

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

31 March 2020

1 reference

Regulation of cell death protease caspase-9 by phosphorylation

31 March 2020

1 reference

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

31 March 2020

1 reference

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

31 March 2020

1 reference

Induction of NF-kappaB by the Akt/PKB kinase

31 March 2020

1 reference

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

31 March 2020

1 reference

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

31 March 2020

1 reference

Regulation of PTEN transcription by p53

31 March 2020

1 reference

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

31 March 2020

1 reference

Increased AKT activity contributes to prostate cancer progression by dramatically accelerating prostate tumor growth and diminishing p27Kip1 expression

31 March 2020

1 reference

Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).

31 March 2020

1 reference

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

31 March 2020

1 reference

Insulin-like growth factor-mediated muscle cell survival: central roles for Akt and cyclin-dependent kinase inhibitor p21

31 March 2020

1 reference

Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells

31 March 2020

1 reference

Wortmannin inhibits serum-induced activation of phosphoinositide 3-kinase and proliferation of CHRF-288 cells

31 March 2020

1 reference

PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells

31 March 2020

1 reference

TOR, a central controller of cell growth

31 March 2020

1 reference

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

31 March 2020

1 reference

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

31 March 2020

1 reference

Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

31 March 2020

1 reference

Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways.

31 March 2020

1 reference

Mammalian TOR: a homeostatic ATP sensor

31 March 2020

1 reference

dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.

31 March 2020

1 reference

Phosphorylation and activation of p70s6k by PDK1

31 March 2020

1 reference

Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases

31 March 2020

1 reference

Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxicity in natural killer cells

31 March 2020

1 reference

Protein kinase B and rac are activated in parallel within a phosphatidylinositide 3OH-kinase-controlled signaling pathway

31 March 2020

1 reference

Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

31 March 2020

1 reference

P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

31 March 2020

1 reference

Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices

31 March 2020

1 reference

Role of the PI3K regulatory subunit in the control of actin organization and cell migration

31 March 2020

1 reference

Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a)

31 March 2020

1 reference

Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway

31 March 2020

1 reference

Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB.

31 March 2020

1 reference

PIK3CA is implicated as an oncogene in ovarian cancer.

31 March 2020

1 reference

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

31 March 2020

1 reference

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

31 March 2020

1 reference

Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas

31 March 2020

1 reference

Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

31 March 2020

1 reference

Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptor

31 March 2020

1 reference

A novel amplification at 17q21-23 in ovarian cancer cell lines detected by comparative genomic hybridization.

31 March 2020

1 reference

Detecting activation of ribosomal protein S6 kinase by complementary DNA and tissue microarray analysis

31 March 2020

1 reference

Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity

31 March 2020

1 reference

The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region

31 March 2020

1 reference

Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

31 March 2020

1 reference

The conserved phosphoinositide 3-kinase pathway determines heart size in mice

31 March 2020

1 reference

Akt/protein kinase B promotes organ growth in transgenic mice

31 March 2020

1 reference

Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo

31 March 2020

1 reference

Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

31 March 2020

1 reference

Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression

31 March 2020

1 reference

Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice

31 March 2020

1 reference

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

31 March 2020

1 reference

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

31 March 2020

1 reference

Pten is essential for embryonic development and tumour suppression

31 March 2020

1 reference

Targeting the BCR-ABL tyrosine kinase in chronic myeloid leukemia

31 March 2020

1 reference

Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome

31 March 2020

1 reference

Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a phase I study

31 March 2020

1 reference

Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase

31 March 2020

1 reference

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

31 March 2020

1 reference

W mutant mice with mild or severe developmental defects contain distinct point mutations in the kinase domain of the c-kit receptor

31 March 2020

1 reference

Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.

31 March 2020

1 reference

An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice

31 March 2020

1 reference

Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

31 March 2020

1 reference

Dissection of angiogenic signaling in zebrafish using a chemical genetic approach

31 March 2020

1 reference

PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy

31 March 2020

1 reference

PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells

31 March 2020

1 reference

TEP1, the yeast homolog of the human tumor suppressor gene PTEN/MMAC1/TEP1, is linked to the phosphatidylinositol pathway and plays a role in the developmental process of sporulation

31 March 2020

1 reference

Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast

31 March 2020

1 reference

The TOR signaling cascade regulates gene expression in response to nutrients

31 March 2020

1 reference

Regulation of longevity and stress resistance by Sch9 in yeast

31 March 2020

1 reference

A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans

31 March 2020

1 reference

daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans

31 March 2020

1 reference

A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans

31 March 2020

1 reference

Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling

31 March 2020

1 reference

The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway

31 March 2020

1 reference

Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB.

31 March 2020

1 reference

Regulation of cellular growth by the Drosophila target of rapamycin dTOR

31 March 2020

1 reference

Drosophila S6 kinase: a regulator of cell size

31 March 2020

1 reference

The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila

31 March 2020

1 reference

Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway

31 March 2020

1 reference

Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways

31 March 2020

1 reference

Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma

31 March 2020

1 reference

Weakening link to colorectal cancer?

31 March 2020

1 reference

Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha

31 March 2020

1 reference

Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase.

31 March 2020

1 reference

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

31 March 2020

1 reference

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

31 March 2020

1 reference

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

31 March 2020

1 reference

AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells

31 March 2020

1 reference

PTEN methylation is associated with advanced stage and microsatellite instability in endometrial carcinoma

31 March 2020

1 reference

PTEN/MMAC1 mutations in hepatocellular carcinomas: somatic inactivation of both alleles in tumors

31 March 2020

1 reference

Identification of PTEN mutations in metastatic melanoma specimens

31 March 2020

1 reference

Epigenetic PTEN silencing in malignant melanomas without PTEN mutation

31 March 2020

1 reference

Mutation analysis of the PTEN/MMAC1 gene in cancers of the digestive tract

31 March 2020

1 reference

Mutation analysis of the PTEN/MMAC1 gene in lung cancer

31 March 2020

1 reference

Somatic mutations of the PTEN tumor suppressor gene in sporadic follicular thyroid tumors

31 March 2020

1 reference

Mutational analysis of the PTEN/MMAC1 gene in non-Hodgkin's lymphoma

31 March 2020

1 reference

Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.

31 March 2020

1 reference

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

31 March 2020

1 reference

Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

31 March 2020

1 reference

Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction

31 March 2020

1 reference

Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration

31 March 2020

1 reference

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10 November 2019

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