Allosteric beta1 integrin antibodies that stabilize the low affinity state by preventing the swing-out of the hybrid domain (Q44881202)

7 December 2017

title

Allosteric beta1 integrin antibodies that stabilize the low affinity state by preventing the swing-out of the hybrid domain (English)

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7 December 2017

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Bing-Hao Luo

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7 December 2017

Konstantin Strokovich

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7 December 2017

Thomas Walz

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7 December 2017

Timothy A Springer

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7 December 2017

Junichi Takagi

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7 December 2017

language of work or name

English

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publication date

27 April 2004

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Journal of Biological Chemistry

7 December 2017

published in

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7 December 2017

volume

279

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7 December 2017

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7 December 2017

page(s)

27466-27471

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Integrins: bidirectional, allosteric signaling machines

7 December 2017

cites work

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Integrin activation takes shape

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Integrin avidity regulation: are changes in affinity and conformation underemphasized?

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Integrin activation and structural rearrangement

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Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling

21 January 2018

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Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins

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A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face

21 January 2018

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Requirement for VLA-4 and VLA-5 integrins in lymphoma cells binding to and migration beneath stromal cells in culture

21 January 2018

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Analysis of fibronectin receptor function with monoclonal antibodies: roles in cell adhesion, migration, matrix assembly, and cytoskeletal organization

21 January 2018

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Regulation of fibronectin receptor distribution

21 January 2018

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Antibodies to different members of the β1 (CD29) integrins induce homotypic and heterotypic cellular aggregation

21 January 2018

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Activated conformations of very late activation integrins detected by a group of antibodies (HUTS) specific for a novel regulatory region (355-425) of the common beta 1 chain

21 January 2018

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The function of multiple extracellular matrix receptors in mediating cell adhesion to extracellular matrix: preparation of monoclonal antibodies to the fibronectin receptor that specifically inhibit cell adhesion to fibronectin and react with platel

21 January 2018

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Structure of integrin alpha5beta1 in complex with fibronectin

21 January 2018

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SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fields

21 January 2018

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Regulation of integrin function: evidence that bivalent-cation-induced conformational changes lead to the unmasking of ligand-binding sites within integrin alpha5 beta1.

21 January 2018

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Epitope mapping of antibodies to the C-terminal region of the integrin beta 2 subunit reveals regions that become exposed upon receptor activation

21 January 2018

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Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand

21 January 2018

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Locking the beta3 integrin I-like domain into high and low affinity conformations with disulfides

21 January 2018

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Structural and functional studies with antibodies to the integrin beta 2 subunit. A model for the I-like domain

21 January 2018

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Multiple discontinuous ligand-mimetic antibody binding sites define a ligand binding pocket in integrin alpha(IIb)beta(3).

21 January 2018

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21 January 2018

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Defining the Topology of Integrin α5β1-Fibronectin Interactions Using Inhibitory Anti-α5 and Anti-β1 Monoclonal Antibodies

21 January 2018

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The Inhibitory Anti-β1 Integrin Monoclonal Antibody 13 Recognizes an Epitope That Is Attenuated by Ligand Occupancy

21 January 2018

1 reference

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Identification of a novel anti-integrin monoclonal antibody that recognises a ligand-induced binding site epitope on the β1 subunit

21 January 2018

1 reference

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Conformational Changes in the Integrin βA Domain Provide a Mechanism for Signal Transduction via Hybrid Domain Movement

21 January 2018

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Suppressor effects and cyclic AMP accumulation by the CD29 molecule of CD4+ lymphocytes

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M404354200

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7 December 2017

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