Integrin activation and structural rearrangement (Q30848202)

27 June 2017

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title

Integrin activation and structural rearrangement (English)

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27 June 2017

Junichi Takagi

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27 June 2017

Timothy A Springer

series ordinal

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27 June 2017

publication date

1 August 2002

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27 June 2017

published in

Immunological Reviews

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27 June 2017

volume

186

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27 June 2017

page(s)

141-163

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Integrins: versatility, modulation, and signaling in cell adhesion

27 June 2017

cites work

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Exposure of platelet fibrinogen receptors by ADP and epinephrine

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

The dynamic regulation of integrin adhesiveness

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Stimulation of integrin-mediated adhesion of T lymphocytes and monocytes: two mechanisms with divergent biological consequences

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Regulation of leukocyte integrin function: affinity vs. avidity

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Are changes in integrin affinity and conformation overemphasized?

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

The actin cytoskeleton regulates LFA-1 ligand binding through avidity rather than affinity changes

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Crystal structure of the extracellular segment of integrin alpha Vbeta3

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

The role of the specificity-determining loop of the integrin beta subunit I-like domain in autonomous expression, association with the alpha subunit, and ligand binding

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Crystal structure of a tandem pair of fibronectin type III domains from the cytoplasmic tail of integrin alpha 6beta 4

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Folding of the N-terminal, ligand-binding region of integrin alpha-subunits into a beta-propeller domain

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Experimental support for a beta-propeller domain in integrin alpha-subunits and a calcium binding site on its lower surface

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

A novel Ca2+ binding beta hairpin loop better resembles integrin sequence motifs than the EF hand

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Amino acid residues in the alpha IIb subunit that are critical for ligand binding to integrin alpha IIbbeta 3 are clustered in the beta-propeller model

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

A novel divalent cation-binding site in the A domain of the beta 2 integrin CR3 (CD11b/CD18) is essential for ligand binding

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b/CD18) for four distinct adhesion ligands.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

The structure of the beta-propeller domain and C-terminal region of the integrin alphaM subunit. Dependence on beta subunit association and prediction of domains.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Domains in plexins: links to integrins and transcription factors

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Assignment of disulphide bonds in human platelet GPIIIa. A disulphide pattern for the beta-subunits of the integrin family

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Amino acid residues in the PSI domain and cysteine-rich repeats of the integrin beta2 subunit that restrain activation of the integrin alpha(X)beta(2).

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Evolution of domain families

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Folding of the conserved domain but not of flanking regions in the integrin beta2 subunit requires association with the alpha subunit

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Folding of the beta-propeller domain of the integrin alphaL subunit is independent of the I domain and dependent on the beta2 subunit

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Multiple discontinuous ligand-mimetic antibody binding sites define a ligand binding pocket in integrin alpha(IIb)beta(3).

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

The top of the inserted-like domain of the integrin lymphocyte function-associated antigen-1 beta subunit contacts the alpha subunit beta -propeller domain near beta-sheet 3

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Definition of EGF-like, closely interacting modules that bear activation epitopes in integrin beta subunits

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Defining the repeating elements in the cysteine-rich region (CRR) of the CD18 integrin beta 2 subunit

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Epitope mapping of antibodies to the C-terminal region of the integrin beta 2 subunit reveals regions that become exposed upon receptor activation

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Two conformations of the integrin A-domain (I-domain): a pathway for activation?

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Cation binding to the integrin CD11b I domain and activation model assessment

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

The role of the divalent cation in the structure of the I domain from the CD11a/CD18 integrin

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

NMR solution structure of the inserted domain of human leukocyte function associated antigen-1

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Crystal Structure of the I Domain from Integrin α2β1

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Structural basis of collagen recognition by integrin alpha2beta1

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Crystal structure of the alpha1beta1 integrin I-domain: insights into integrin I-domain function

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Trench-shaped binding sites promote multiple classes of interactions between collagen and the adherence receptors, alpha(1)beta(1) integrin and Staphylococcus aureus cna MSCRAMM

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

The integrin I domain: crystals, metals and related artefacts

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Conformational changes in tertiary structure near the ligand binding site of an integrin I domain.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Computational design of an integrin I domain stabilized in the open high affinity conformation

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

De Novo Protein Design: Fully Automated Sequence Selection

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

An isoleucine-based allosteric switch controls affinity and shape shifting in integrin CD11b A-domain

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin alphaL I domains with high affinity and antagonist activity in vivo

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

NMR and mutagenesis evidence for an I domain allosteric site that regulates lymphocyte function-associated antigen 1 ligand binding

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Functional consequences of integrin gene mutations in mice

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Effects of administration of a single dose of a humanized monoclonal antibody to CD11a on the immunobiology and clinical activity of psoriasis

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide lead

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Binding site elucidation of hydantoin-based antagonists of LFA-1 using multidisciplinary technologies: evidence for the allosteric inhibition of a protein--protein interaction

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 2. Mechanism of inhibition and structure-based improvement of pharmaceutical properties

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Small molecule inhibitors induce conformational changes in the I domain and the I-like domain of lymphocyte function-associated antigen-1. Molecular insights into integrin inhibition

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

A discrete site modulates activation of I domains. Application to integrin alphaMbeta2.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Crystal structure of the von Willebrand Factor A1 domain and implications for the binding of platelet glycoprotein Ib

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Activation-induced conformational changes in the I domain region of lymphocyte function-associated antigen 1.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

A Binding Interface on the I Domain of Lymphocyte Function-associated Antigen-1 (LFA-1) Required for Specific Interaction with Intercellular Adhesion Molecule 1 (ICAM-1)

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Topography of ligand-induced binding sites, including a novel cation-sensitive epitope (AP5) at the amino terminus, of the human integrin beta 3 subunit

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Specific association of CD63 with the VLA-3 and VLA-6 integrins

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Alpha 4 beta 1 integrin-dependent cell adhesion is regulated by a low affinity receptor pool that is conformationally responsive to ligand

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Integrin cytoplasmic domains mediate inside-out signal transduction

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Breaking the integrin hinge. A defined structural constraint regulates integrin signaling

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Regulation of Adhesion to ICAM-1 by the Cytoplasmic Domain of LFA-1 Integrin β Subunit

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Modulation of the affinity of integrin alpha IIb beta 3 (GPIIb-IIIa) by the cytoplasmic domain of alpha IIb

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

The conserved membrane-proximal region of an integrin cytoplasmic domain specifies ligand binding affinity.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Interchangeable alpha chain cytoplasmic domains play a positive role in control of cell adhesion mediated by VLA-4, a beta 1 integrin

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Transmembrane-truncated alphavbeta3 integrin retains high affinity for ligand binding: evidence for an 'inside-out' suppressor?

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

The thioesterase domain from a nonribosomal peptide synthetase as a cyclization catalyst for integrin binding peptides

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Ligands "activate" integrin alpha IIb beta 3 (platelet GPIIb-IIIa).

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Structural and functional studies with antibodies to the integrin beta 2 subunit. A model for the I-like domain

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Micromolar Ca2+ concentrations are essential for Mg2+-dependent binding of collagen by the integrin alpha 2beta 1 in human platelets

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

The lymphocyte function-associated antigen 1 I domain is a transient binding module for intercellular adhesion molecule (ICAM)-1 and ICAM-3 in hydrodynamic flow

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Green fluorescent protein (GFP) tagged to the cytoplasmic tail of alphaIIb or beta3 allows the expression of a fully functional integrin alphaIIb(beta3): effect of beta3GFP on alphaIIb(beta3) ligand binding

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Differential dynamics of alpha 5 integrin, paxillin, and alpha-actinin during formation and disassembly of adhesions in migrating cells

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Chemokines trigger immediate beta2 integrin affinity and mobility changes: differential regulation and roles in lymphocyte arrest under flow

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

Mapping the intercellular adhesion molecule-1 and -2 binding site on the inserted domain of leukocyte function-associated antigen-1.

1 reference

https://api.crossref.org/works/10.1034%2FJ.1600-065X.2002.18613.X

7 January 2021

10.1034/J.1600-065X.2002.18613.X

Identifiers

DOI

1 reference

27 June 2017

1 reference