Integrin activation takes shape (Q34817107)

4 August 2017

4 references

31 July 2019

15 December 2019

26 August 2020

7 November 2020

Integrin activation takes shape (English)

1 reference

cell adhesion mediated by integrin

4 August 2017

main subject

cell surface receptor

1 reference

31 July 2019

1 reference

15 December 2019

1 reference

1 reference

cell-cell adhesion mediated by integrin

Gene Ontology ID

GO:0033622

1 reference

positive regulation of integrin activation by cell surface receptor linked signal transduction

Gene Ontology ID

GO:0033631

1 reference

1 reference

26 August 2020

1 reference

7 November 2020

R C Liddington

1 reference

4 August 2017

M H Ginsberg

series ordinal

1 reference

4 August 2017

language of work or name

English

0 references

publication date

3 September 2002

1 reference

4 August 2017

2 September 2002

4 references

31 July 2019

15 December 2019

26 August 2020

7 November 2020

1 reference

inferred from page(s)

published in

Journal of Cell Biology

5 references

4 August 2017

31 July 2019

15 December 2019

26 August 2020

7 November 2020

158

1 reference

4 August 2017

1 reference

4 August 2017

page(s)

833-839

1 reference

Solution structures of the cytoplasmic tail complex from platelet integrin alpha IIb- and beta 3-subunits

4 August 2017

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

The phosphotyrosine binding-like domain of talin activates integrins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

Molecular basis for interaction between Icap1 alpha PTB domain and beta 1 integrin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

Oligomerization of the integrin alphaIIbbeta3: roles of the transmembrane and cytoplasmic domains

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

Crystal structure of the extracellular segment of integrin alpha Vbeta3

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

NMR analysis of structure and dynamics of the cytosolic tails of integrin alpha IIb beta 3 in aqueous solution

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

Calpain cleavage promotes talin binding to the beta 3 integrin cytoplasmic domain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

Conformation, localization, and integrin binding of talin depend on its interaction with phosphoinositides

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

An isoleucine-based allosteric switch controls affinity and shape shifting in integrin CD11b A-domain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

ERM-Merlin and EBP50 protein families in plasma membrane organization and function

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

Integrin cytoplasmic domain-binding proteins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

Identification of shc as the primary protein binding to the tyrosine-phosphorylated beta 3 subunit of alpha IIbbeta 3 during outside-in integrin platelet signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

Computational design of an integrin I domain stabilized in the open high affinity conformation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

Structural basis of collagen recognition by integrin alpha2beta1

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

A structural basis for integrin activation by the cytoplasmic tail of the alpha IIb-subunit

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

NMR solution structure of the inserted domain of human leukocyte function associated antigen-1

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

Diversity in protein recognition by PTB domains

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

Effects of ligand-mimetic peptides Arg-Gly-Asp-X (X = Phe, Trp, Ser) on alphaIIbbeta3 integrin conformation and oligomerization

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

Disruption of the talin gene compromises focal adhesion assembly in undifferentiated but not differentiated embryonic stem cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

Phosphoinositide 3-OH kinase activates the beta2 integrin adhesion pathway and induces membrane recruitment of cytohesin-1

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

Transmembrane-truncated alphavbeta3 integrin retains high affinity for ligand binding: evidence for an 'inside-out' suppressor?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

Structural aspects of heterotrimeric G-protein signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

A genetic analysis of integrin function: Glanzmann thrombasthenia in vitro

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

Folding of the N-terminal, ligand-binding region of integrin alpha-subunits into a beta-propeller domain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

Integrins: emerging paradigms of signal transduction

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

Breaking the integrin hinge. A defined structural constraint regulates integrin signaling

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18)

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

Regulation of integrin affinity states through an NPXY motif in the beta subunit cytoplasmic domain.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

Long range propagation of conformational changes in integrin alpha IIb beta 3

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

Integrin cytoplasmic domains mediate inside-out signal transduction

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

Interaction of plasma membrane fibronectin receptor with talin--a transmembrane linkage

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

Sequence and domain structure of talin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

Immobilized Arg-Gly-Asp (RGD) peptides of varying lengths as structural probes of the platelet glycoprotein IIb/IIIa receptor

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2173150

Determination of the Border between the Transmembrane and Cytoplasmic Domains of Human Integrin Subunits

8 July 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200206011

A membrane-distal segment of the integrin alpha IIb cytoplasmic domain regulates integrin activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200206011

Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200206011

Integrin beta cytoplasmic domains differentially bind to cytoskeletal proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200206011

Defining the Topology of Integrin α5β1-Fibronectin Interactions Using Inhibitory Anti-α5 and Anti-β1 Monoclonal Antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1083%2FJCB.200206011

Platelet membrane glycoprotein IIb-IIIa complex incorporated into phospholipid vesicles. Preparation and morphology

21 January 2018

1 reference

12 December 2020

Does the integrin alphaA domain act as a ligand for its betaA domain?

1 reference

12 December 2020

Beta 2 (CD18) mutations abolish ligand recognition by I domain integrins LFA-1 (alpha L beta 2, CD11a/CD18) and MAC-1 (alpha M beta 2, CD11b/CD18)

1 reference

12 December 2020

Cellular activation of leukocyte function-associated antigen-1 and its affinity are regulated at the I domain allosteric site

1 reference

12 December 2020

The inner world of cell adhesion: integrin cytoplasmic domains

1 reference

12 December 2020

C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1

1 reference

12 December 2020

Identifiers

DOI

10.1083/JCB.200206011

1 reference

4 August 2017

1 reference

4 August 2017

1 reference