Presenilin 1 and Presenilin 2 Target γ-Secretase Complexes to Distinct Cellular Compartments (Q30780773)

18 August 2017

Presenilin 1 and Presenilin 2 Target γ-Secretase Complexes to Distinct Cellular Compartments (English)

1 reference

18 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27059953%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Xavier Meckler

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27059953%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

language of work or name

English

0 references

publication date

8 April 2016

1 reference

Journal of Biological Chemistry

18 August 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27059953%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

volume

291

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27059953%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27059953%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

page(s)

12821-12837

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27059953%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

3 June 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4933450/fullTextXML

inferred from PubMed Central ID database lookup

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Signature amyloid β profiles are produced by different γ-secretase complexes

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20 June 2018

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Aminopeptidase A contributes to the N-terminal truncation of amyloid beta-peptide

20 June 2018

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S-palmitoylation of gamma-secretase subunits nicastrin and APH-1

20 June 2018

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Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution

20 June 2018

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20 June 2018

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Amyloid precursor protein trafficking, processing, and function

20 June 2018

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20 June 2018

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Endosomal entry regulates Notch receptor activation in Drosophila melanogaster

20 June 2018

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Active gamma-secretase complexes contain only one of each component

20 June 2018

1 reference

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Endoplasmic reticulum retention of the gamma-secretase complex component Pen2 by Rer1.

20 June 2018

1 reference

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Culturing hippocampal neurons

20 June 2018

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Rer1p competes with APH-1 for binding to nicastrin and regulates gamma-secretase complex assembly in the early secretory pathway

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis

20 June 2018

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Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

Aph-1 interacts at the cell surface with proteins in the active gamma-secretase complex and membrane-tethered Notch.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

Gamma-secretase complex assembly within the early secretory pathway

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage

20 June 2018

1 reference

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The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity

20 June 2018

1 reference

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Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity

20 June 2018

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Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

Identification of distinct gamma-secretase complexes with different APH-1 variants

20 June 2018

1 reference

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Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor

20 June 2018

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The presenilin proteins are components of multiple membrane-bound complexes that have different biological activities

20 June 2018

1 reference

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Enhanced generation of intracellular Abeta42 amyloid peptide by mutation of presenilins PS1 and PS2.

20 June 2018

1 reference

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Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

BACE1- and BACE2-expressing human cells: characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

APP processing and synaptic function

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

The role of presenilin cofactors in the gamma-secretase complex

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

Presenilin 1 is required for maturation and cell surface accumulation of nicastrin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

Subcellular compartment and molecular subdomain of beta-amyloid precursor protein relevant to the Abeta 42-promoting effects of Alzheimer mutant presenilin 2.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

Presenilins interact with Rab11, a small GTPase involved in the regulation of vesicular transport

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

Alzheimer's disease-linked mutation of presenilin 2 (N141I-PS2) drastically lowers APPalpha secretion: control by the proteasome.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

Cleavage of foot-and-mouth disease virus polyprotein is mediated by residues located within a 19 amino acid sequence

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

A phase 3 trial of semagacestat for treatment of Alzheimer's disease

20 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M115.708297

Reconstitution of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M115.708297

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M115.708297

Transfection of cultured primary neurons via nucleofection

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M115.708297

TrkA receptor activation by nerve growth factor induces shedding of the p75 neurotrophin receptor followed by endosomal gamma-secretase-mediated release of the p75 intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M115.708297

The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M115.708297

The extreme C terminus of presenilin 1 is essential for gamma-secretase complex assembly and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M115.708297

Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M115.708297

Presenilin/gamma-secretase activity regulates protein clearance from the endocytic recycling compartment

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M115.708297

Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M115.708297

Inhibition of Receptor-mediated Endocytosis Demonstrates Generation of Amyloid β-Protein at the Cell Surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M115.708297

Activation of beta2-adrenergic receptor stimulates gamma-secretase activity and accelerates amyloid plaque formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M115.708297

Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M115.708297

Visualization of specific γ-secretase complexes using bimolecular fluorescence complementation

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

Lack of effect of Presenilin 1, betaAPP and their Alzheimer's disease-related mutated forms on Xenopus oocytes membrane currents

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4933450

Design and Construction of 2A Peptide-Linked Multicistronic Vectors

25 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27059953

12 December 2020

inferred from PubMed ID database lookup

Identification of presenilin 1-selective γ-secretase inhibitors with reconstituted γ-secretase complexes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27059953

12 December 2020

inferred from PubMed ID database lookup

Analysis of the aphthovirus 2A/2B polyprotein ‘cleavage’ mechanism indicates not a proteolytic reaction, but a novel translational effect: a putative ribosomal ‘skip’

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27059953

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1074/JBC.M115.708297

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27059953%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27059953%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

PubMed publication ID

27059953

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27059953%20AND%20SRC:MED&resulttype=core&format=json