aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation (Q34137893)

31 July 2017

title

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation (English)

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31 July 2017

main subject

Nicastrin Dmel_CG7012

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Presenilin enhancer Dmel_CG33198

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Presenilin Dmel_CG18803

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Anterior pharynx defective 1 Dmel_CG2855

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Gamma-secretase subunit pen-2 CELE_T28D6.9

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Gamma-secretase subunit aph-1 CELE_VF36H2L.1

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ORCID Public Data File 2021

Javier Apfeld

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author name string

Ross Francis

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31 July 2017

Garth McGrath

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31 July 2017

Jianhuan Zhang

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31 July 2017

David A Ruddy

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31 July 2017

Mary Sym

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31 July 2017

Monique Nicoll

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31 July 2017

Mark Maxwell

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31 July 2017

Bing Hai

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31 July 2017

Michael C Ellis

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31 July 2017

Annette L Parks

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31 July 2017

Wei Xu

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31 July 2017

Jinhe Li

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31 July 2017

Mark Gurney

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31 July 2017

Richard L Myers

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31 July 2017

Carol S Himes

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31 July 2017

Ronald Hiebsch

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31 July 2017

Cara Ruble

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31 July 2017

Jeffrey S Nye

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31 July 2017

Daniel Curtis

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31 July 2017

language of work or name

English

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publication date

1 July 2002

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31 July 2017

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inferred from page(s)

published in

Developmental Cell

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31 July 2017

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31 July 2017

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31 July 2017

page(s)

85-97

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Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons

31 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

Notch signaling: cell fate control and signal integration in development

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

Nicastrin binds to membrane-tethered Notch

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

The SEL-12 presenilin mediates induction of the Caenorhabditis elegans uterine pi cell fate

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

Mice lacking both presenilin genes exhibit early embryonic patterning defects

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

A portrait of Alzheimer secretases--new features and familiar faces

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

Transgenic Drosophila expressing human amyloid precursor protein show gamma-secretase activity and a blistered-wing phenotype

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

The lin-12 locus specifies cell fates in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

A full genome scan for late onset Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

Subcellular localization of presenilins: association with a unique membrane pool in cultured cells

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

The LIN-12/Notch signaling pathway and its regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

A common enzyme connects notch signaling and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

Endogenous presenilin-1 targets to endocytic rather than biosynthetic compartments

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

APH-2/nicastrin functions in LIN-12/Notch signaling in the Caenorhabditis elegans somatic gonad.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

Drosophila nicastrin is essential for the intramembranous cleavage of notch

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

Endoproteolytic Processing and Stabilization of Wild-type and Mutant Presenilin

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

Nuclear access and action of notch in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

Presenilin is required for activity and nuclear access of Notch in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

Evidence That Levels of Presenilins (PS1 and PS2) Are Coordinately Regulated by Competition for Limiting Cellular Factors

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

Secretase targets for Alzheimer's disease: identification and therapeutic potential

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

1 reference

https://api.crossref.org/works/10.1016%2FS1534-5807%2802%2900189-2

7 January 2021

10.1016/S1534-5807(02)00189-2

Identifiers

DOI

1 reference

release_q7yyffvd7zajbn4i5yzu5u2yj4

31 July 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/q7yyffvd7zajbn4i5yzu5u2yj4

24 November 2022

mapped directly with Wikidata item

1 reference