The extreme C terminus of presenilin 1 is essential for gamma-secretase complex assembly and activity (Q45025052)

8 December 2017

title

The extreme C terminus of presenilin 1 is essential for gamma-secretase complex assembly and activity (English)

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8 December 2017

Bengt Winblad

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8 December 2017

Anna Bergman

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8 December 2017

Hanna Laudon

series ordinal

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8 December 2017

Johan Lundkvist

series ordinal

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8 December 2017

Jan Näslund

series ordinal

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8 December 2017

language of work or name

English

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publication date

20 August 2004

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Journal of Biological Chemistry

8 December 2017

published in

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8 December 2017

volume

279

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8 December 2017

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8 December 2017

page(s)

45564-45572

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Biochemistry. Intramembrane proteases--mixing oil and water

8 December 2017

cites work

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21 January 2018

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Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

21 January 2018

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A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

21 January 2018

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Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

21 January 2018

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A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis

21 January 2018

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Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).

21 January 2018

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Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

21 January 2018

1 reference

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Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1.

21 January 2018

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

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APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

21 January 2018

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Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

21 January 2018

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aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

1 reference

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PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

21 January 2018

1 reference

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Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

21 January 2018

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Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

21 January 2018

1 reference

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

1 reference

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Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin

21 January 2018

1 reference

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Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases

21 January 2018

1 reference

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The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins

21 January 2018

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A sensitive and quantitative assay for measuring cleavage of presenilin substrates

21 January 2018

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Notch receptor cleavage depends on but is not directly executed by presenilins

21 January 2018

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Mice lacking both presenilin genes exhibit early embryonic patterning defects

21 January 2018

1 reference

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Pen-2 is sequestered in the endoplasmic reticulum and subjected to ubiquitylation and proteasome-mediated degradation in the absence of presenilin

21 January 2018

1 reference

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Co-expressed presenilin 1 NTF and CTF form functional gamma-secretase complexes in cells devoid of full-length protein

21 January 2018

1 reference

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APP intracellular domain formation and unaltered signaling in the presence of familial Alzheimer's disease mutations

21 January 2018

1 reference

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Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

21 January 2018

1 reference

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X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407717200

Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment

21 January 2018

1 reference

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Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407717200

Calsenilin reverses presenilin-mediated enhancement of calcium signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407717200

Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407717200

Different cofactor activities in gamma-secretase assembly: evidence for a nicastrin-Aph-1 subcomplex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407717200

Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M407717200

21 January 2018

Identifiers

DOI

10.1074/JBC.M407717200

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8 December 2017

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