Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch (Q33883369)

29 July 2017

title

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch (English)

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29 July 2017

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Ray WJ

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29 July 2017

Yao M

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29 July 2017

Mumm J

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29 July 2017

Schroeter EH

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29 July 2017

Saftig P

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29 July 2017

Wolfe M

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29 July 2017

Selkoe DJ

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29 July 2017

Kopan R

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29 July 2017

Goate AM

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29 July 2017

language of work or name

English

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publication date

1 December 1999

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Journal of Biological Chemistry

29 July 2017

published in

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29 July 2017

volume

274

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29 July 2017

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29 July 2017

page(s)

36801-36807

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Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

29 July 2017

cites work

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https://api.crossref.org/works/10.1074%2FJBC.274.51.36801

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.51.36801

The ins and outs of notch signaling

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.51.36801

Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.51.36801

The Notch1 receptor is cleaved constitutively by a furin-like convertase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.51.36801

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.51.36801

Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.51.36801

Nuclear access and action of notch in vivo

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.51.36801

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.51.36801

HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.51.36801

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.51.36801

Skeletal and CNS defects in Presenilin-1-deficient mice

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.51.36801

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.51.36801

The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.51.36801

Presenilins: genes for life and death

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.51.36801

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.51.36801

Presenilin is required for activity and nuclear access of Notch in Drosophila

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.51.36801

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.51.36801

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.51.36801

Interaction between amyloid precursor protein and presenilins in mammalian cells: Implications for the pathogenesis of Alzheimer disease

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.51.36801

Evidence for a physical interaction between presenilin and Notch

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.51.36801

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.51.36801

Effects of PS1 deficiency on membrane protein trafficking in neurons

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.51.36801

Presenilin 1 interaction in the brain with a novel member of the Armadillo family

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.51.36801

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.51.36801

Endogenous presenilin 1 redistributes to the surface of lamellipodia upon adhesion of Jurkat cells to a collagen matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.51.36801

Localization of Alzheimer-associated presenilin 1 in transfected COS-7 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.51.36801

Characterization of Drosophila Presenilin and its colocalization with Notch during development

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.51.36801

Notch is expressed in adult brain, is coexpressed with presenilin-1, and is altered in Alzheimer disease

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.51.36801

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.274.51.36801

Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.51.36801

Evidence That Intramolecular Associations between Presenilin Domains Are Obligatory for Endoproteolytic Processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.51.36801

21 January 2018

Identifiers

DOI

10.1074/JBC.274.51.36801

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29 July 2017

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