A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease. (Q39665939)

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10 February 2020

title

A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease (English)

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10 February 2020

Hiroaki Fukumoto

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10 February 2020

Hideki Takahashi

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10 February 2020

Naoki Tarui

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10 February 2020

Junji Matsui

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10 February 2020

Mitsuhiro Hirode

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10 February 2020

Masumi Sagayama

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Ryouta Maeda

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Makiko Kawamoto

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Kazuko Hirai

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10 February 2020

Jun Terauchi

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10 February 2020

Yasufumi Sakura

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Mitsuru Kakihana

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Kaneyoshi Kato

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Takeshi Iwatsubo

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10 February 2020

Masaomi Miyamoto

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language of work or name

English

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publication date

1 August 2010

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10 February 2020

published in

Journal of Neuroscience

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volume

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issue

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10 February 2020

page(s)

11157-11166

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

10 February 2020

cites work

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12 December 2020

Primary cultures of neuronal and non-neuronal rat brain cells secrete similar proportions of amyloid β peptides ending at Aβ40 and Aβ42

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12 December 2020

Mice lacking both presenilin genes exhibit early embryonic patterning defects

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12 December 2020

Purification and cloning of amyloid precursor protein beta-secretase from human brain

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12 December 2020

Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh.

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12 December 2020

The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.

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12 December 2020

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

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12 December 2020

Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.

1 reference

12 December 2020

Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics

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12 December 2020

Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation

1 reference

12 December 2020

TACE/ADAM-17 enzymatic activity is increased in response to cellular stimulation

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12 December 2020

Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP).

1 reference

12 December 2020

BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

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12 December 2020

Beta-secretase activity increases with aging in human, monkey, and mouse brain.

1 reference

12 December 2020

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

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12 December 2020

Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme

1 reference

12 December 2020

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

1 reference

12 December 2020

Compounds that bind APP and inhibit Abeta processing in vitro suggest a novel approach to Alzheimer disease therapeutics

1 reference

12 December 2020

Age-dependent differential expression of BACE splice variants in brain regions of tg2576 mice

1 reference

12 December 2020

Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice.

1 reference

12 December 2020

Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.

1 reference

12 December 2020

Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease

1 reference

12 December 2020

ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein

1 reference

12 December 2020

Bace1 modulates myelination in the central and peripheral nervous system.

1 reference

12 December 2020

Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo

1 reference

12 December 2020

BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice

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12 December 2020

The proteins BACE1 and BACE2 and beta-secretase activity in normal and Alzheimer's disease brain.

1 reference

12 December 2020

Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice

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12 December 2020

Neurosecretases provide strategies to treat sporadic and familial Alzheimer disorders

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12 December 2020

Beta-amyloid modulation of synaptic transmission and plasticity

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12 December 2020

In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.

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12 December 2020

Loss of presenilin function causes Alzheimer's disease-like neurodegeneration in the mouse

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12 December 2020

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice

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12 December 2020

BACE1 structure and function in health and Alzheimer's disease

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12 December 2020

A closer look at alpha-secretase

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12 December 2020

Boom in the development of non-peptidic beta-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease

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12 December 2020

First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates

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12 December 2020

Novel role of RanBP9 in BACE1 processing of amyloid precursor protein and amyloid beta peptide generation

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12 December 2020

The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex

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12 December 2020

Long Amyloid .beta.-Protein Secreted from Wild-Type Human Neuroblastoma IMR-32 Cells

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12 December 2020

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

1 reference

12 December 2020

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

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12 December 2020

Skeletal and CNS defects in Presenilin-1-deficient mice

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12 December 2020

10.1523/JNEUROSCI.2884-10.2010

Identifiers

DOI

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10 February 2020

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10 February 2020

PubMed publication ID

20720123

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