Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo (Q40199218)

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scientific article published on February 2007

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English	Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo	scientific article published on February 2007

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scholarly article

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Europe PubMed Central

PubMed publication ID

18 September 2017

Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo (English)

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Europe PubMed Central

PubMed publication ID

18 September 2017

author name string

Ishrut Hussain

1

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18 September 2017

Julie Hawkins

2

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18 September 2017

David Harrison

3

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18 September 2017

Christopher Hille

4

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18 September 2017

Gareth Wayne

5

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18 September 2017

Leanne Cutler

6

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18 September 2017

Tania Buck

7

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18 September 2017

Daryl Walter

8

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18 September 2017

Emmanuel Demont

9

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18 September 2017

Colin Howes

10

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18 September 2017

Alan Naylor

11

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18 September 2017

Philip Jeffrey

12

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18 September 2017

Maria I Gonzalez

13

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18 September 2017

Colin Dingwall

14

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18 September 2017

Anton Michel

15

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18 September 2017

Sally Redshaw

16

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18 September 2017

John B Davis

17

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18 September 2017

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publication date

1 February 2007

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18 September 2017

number of pages

8

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inferred from page(s)

Journal of Neurochemistry

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18 September 2017

100

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18 September 2017

3

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18 September 2017

802-809

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18 September 2017

The novel beta-secretase inhibitor KMI-429 reduces amyloid beta peptide production in amyloid precursor protein transgenic and wild-type mice

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04260.X

21 January 2018

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04260.X

21 January 2018

In vivo inhibition of Abeta production by memapsin 2 (beta-secretase) inhibitors

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04260.X

21 January 2018

Characterization of the glycosylation profiles of Alzheimer's beta -secretase protein Asp-2 expressed in a variety of cell lines.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04260.X

21 January 2018

Exclusively targeting beta-secretase to lipid rafts by GPI-anchor addition up-regulates beta-site processing of the amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04260.X

21 January 2018

Drug transport to the brain: key roles for the efflux pump P-glycoprotein in the blood-brain barrier

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04260.X

21 January 2018

Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04260.X

21 January 2018

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04260.X

21 January 2018

Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04260.X

21 January 2018

Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04260.X

21 January 2018

Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04260.X

21 January 2018

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04260.X

21 January 2018

Cognitive correlates of Abeta deposition in male and female mice bearing amyloid precursor protein and presenilin-1 mutant transgenes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04260.X

21 January 2018

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04260.X

21 January 2018

ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04260.X

21 January 2018

Human beta-secretase (BACE) and BACE inhibitors: progress report

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04260.X

21 January 2018

Design and synthesis of highly active Alzheimer's beta-secretase (BACE1) inhibitors, KMI-420 and KMI-429, with enhanced chemical stability

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04260.X

21 January 2018

Amyloid beta peptide load is correlated with increased beta-secretase activity in sporadic Alzheimer's disease patients

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04260.X

21 January 2018

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04260.X

21 January 2018

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04260.X

21 January 2018

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04260.X

21 January 2018

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04260.X

21 January 2018

BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04260.X

21 January 2018

Role of P-glycoprotein on the CNS disposition of amprenavir (141W94), an HIV protease inhibitor

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04260.X

21 January 2018

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04260.X

21 January 2018

Purification and cloning of amyloid precursor protein beta-secretase from human brain

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04260.X

21 January 2018

Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04260.X

21 January 2018

Conformationally biased P3 amide replacements of beta-secretase inhibitors

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04260.X

21 January 2018

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04260.X

21 January 2018

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04260.X

21 January 2018

Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04260.X

21 January 2018

Aminoethylenes: a tetrahedral intermediate isostere yielding potent inhibitors of the aspartyl protease BACE-1.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2006.04260.X

21 January 2018

Identifiers

10.1111/J.1471-4159.2006.04260.X

1 reference

Europe PubMed Central

PubMed publication ID

18 September 2017

release_dr4vsb655raoxei22pe6ei7k5e

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https://api.fatcat.wiki/v0/release/dr4vsb655raoxei22pe6ei7k5e

24 November 2022

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18 September 2017

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