A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease. (Q39665939)

From Wikidata

Jump to navigation Jump to search

The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.

scientific article published on August 2010

Language	Label	Description	Also known as
English	A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease.	scientific article published on August 2010

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20720123%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20720123%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Alzheimer's disease

0 references

0 references

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20720123%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

author name string

Hiroaki Fukumoto

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20720123%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Hideki Takahashi

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20720123%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Naoki Tarui

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20720123%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Junji Matsui

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20720123%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Mitsuhiro Hirode

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20720123%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Masumi Sagayama

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20720123%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Ryouta Maeda

8

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20720123%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Makiko Kawamoto

9

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20720123%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Kazuko Hirai

10

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20720123%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Jun Terauchi

11

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20720123%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Yasufumi Sakura

12

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20720123%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Mitsuru Kakihana

13

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20720123%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Kaneyoshi Kato

14

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20720123%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Takeshi Iwatsubo

15

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20720123%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Masaomi Miyamoto

16

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20720123%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

language of work or name

0 references

publication date

1 August 2010

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20720123%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20720123%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

30

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20720123%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

33

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20720123%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

11157-11166

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20720123%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Primary cultures of neuronal and non-neuronal rat brain cells secrete similar proportions of amyloid β peptides ending at Aβ40 and Aβ42

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mice lacking both presenilin genes exhibit early embryonic patterning defects

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and cloning of amyloid precursor protein beta-secretase from human brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease and Down's syndrome: roles of APP, trophic factors and ACh.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TACE/ADAM-17 enzymatic activity is increased in response to cellular stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP).

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-secretase activity increases with aging in human, monkey, and mouse brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Compounds that bind APP and inhibit Abeta processing in vitro suggest a novel approach to Alzheimer disease therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-dependent differential expression of BACE splice variants in brain regions of tg2576 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bace1 modulates myelination in the central and peripheral nervous system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral administration of a potent and selective non-peptidic BACE-1 inhibitor decreases beta-cleavage of amyloid precursor protein and amyloid-beta production in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The proteins BACE1 and BACE2 and beta-secretase activity in normal and Alzheimer's disease brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurosecretases provide strategies to treat sporadic and familial Alzheimer disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid modulation of synaptic transmission and plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo beta-secretase 1 inhibition leads to brain Abeta lowering and increased alpha-secretase processing of amyloid precursor protein without effect on neuregulin-1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of presenilin function causes Alzheimer's disease-like neurodegeneration in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BACE1 structure and function in health and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A closer look at alpha-secretase

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Boom in the development of non-peptidic beta-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel role of RanBP9 in BACE1 processing of amyloid precursor protein and amyloid beta peptide generation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long Amyloid .beta.-Protein Secreted from Wild-Type Human Neuroblastoma IMR-32 Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Skeletal and CNS defects in Presenilin-1-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/20720123

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.2884-10.2010

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20720123%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20720123%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20720123%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q39665939&oldid=1475502171"