The fungal resistome: a risk and an opportunity for the development of novel antifungal therapies (Q38835045)

6 September 2017

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title

The fungal resistome: a risk and an opportunity for the development of novel antifungal therapies (English)

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6 September 2017

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6 September 2017

Gloria Molero

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Concha Gil

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Jose A Reales-Calderón

series ordinal

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6 September 2017

publication date

3 August 2016

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Future Medicinal Chemistry

6 September 2017

published in

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6 September 2017

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6 September 2017

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6 September 2017

page(s)

1503-1520

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Invasive fungal infections during the neonatal period: diagnosis, treatment and prophylaxis

6 September 2017

cites work

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Anti-Candida drugs--the biochemical basis for their activity

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A global view of antibiotic resistance

21 January 2018

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Origins and evolution of antibiotic resistance

21 January 2018

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Molecular mechanisms of antibacterial multidrug resistance

21 January 2018

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Antifungals: Mechanism of Action and Drug Resistance

21 January 2018

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Antifungal resistance and new strategies to control fungal infections

21 January 2018

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Contribution of mutations in the cytochrome P450 14alpha-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans

21 January 2018

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Clade-specific flucytosine resistance is due to a single nucleotide change in the FUR1 gene of Candida albicans

21 January 2018

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Therapy for fungal diseases: opportunities and priorities

21 January 2018

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Beta-lactamase inhibitors from laboratory to clinic

21 January 2018

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The effect of the echinocandin analogue caspofungin on cell wall glucan synthesis by Cryptococcus neoformans

21 January 2018

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Heteroresistance to fluconazole in Cryptococcus neoformans is intrinsic and associated with virulence

21 January 2018

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Rare and emerging opportunistic fungal pathogens: concern for resistance beyond Candida albicans and Aspergillus fumigatus.

21 January 2018

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In vitro susceptibilities of Aspergillus species to voriconazole, itraconazole, and amphotericin B.

21 January 2018

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Causative agents of nosocomial mycoses

21 January 2018

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Fluconazole-resistant pathogens Candida inconspicua and C. norvegensis: DNA sequence diversity of the rRNA intergenic spacer region, antifungal drug susceptibility, and extracellular enzyme production

21 January 2018

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Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Heteroresistance of Cryptococcus gattii to fluconazole

21 January 2018

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Antifungal drug resistance: mechanisms, epidemiology, and consequences for treatment

21 January 2018

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Fungal echinocandin resistance.

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC-2016-0051

FsFKS1, the 1,3-beta-glucan synthase from the caspofungin-resistant fungus Fusarium solani

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Antifungal drug resistance: do molecular methods provide a way forward?

21 January 2018

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Mode of action and resistance to azole antifungals associated with the formation of 14 alpha-methylergosta-8,24(28)-dien-3 beta,6 alpha-diol.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Echinocandin antifungal drugs in fungal infections: a comparison

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

A naturally occurring proline-to-alanine amino acid change in Fks1p in Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis accounts for reduced echinocandin susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Candida albicans and Candida glabrata clinical isolates exhibiting reduced echinocandin susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Multiple resistance mechanisms among Aspergillus fumigatus mutants with high-level resistance to itraconazole.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

In-vitro susceptibility of Aspergillus spp. isolates to amphotericin B and itraconazole

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

The intrinsic resistome of bacterial pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Characterization of the polymyxin B resistome of Pseudomonas aeruginosa.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Intrinsic antibiotic resistance: mechanisms, origins, challenges and solutions

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

The antibiotic resistome: challenge and opportunity for therapeutic intervention.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

The intrinsic resistome of Pseudomonas aeruginosa to β-lactams.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Genetic determinants involved in the susceptibility of Pseudomonas aeruginosa to beta-lactam antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Determination of antibiotic hypersensitivity among 4,000 single-gene-knockout mutants of Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

The neglected intrinsic resistome of bacterial pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Investigation of multidrug efflux pumps in relation to fluconazole resistance in Candida albicans biofilms

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Azole susceptibility and transcriptome profiling in Candida albicans mitochondrial electron transport chain complex I mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Role of Sho1p adaptor in the pseudohyphal development, drugs sensitivity, osmotolerance and oxidant stress adaptation in the opportunistic yeast Candida lusitaniae.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Hypersusceptibility to azole antifungals in a clinical isolate of Candida glabrata with reduced aerobic growth

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Cyclic AMP Signaling Pathway Modulates Susceptibility of Candida Species and Saccharomyces cerevisiae to Antifungal Azoles and Other Sterol Biosynthesis Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Inhibition of resistance and virulence in itraconazole-resistant Candida albicans by butylated hydroxyanisole

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Genetic dissection of azole resistance mechanisms in Candida albicans and their validation in a mouse model of disseminated infection

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Identification and characterization of a Cryptococcus neoformans ATP binding cassette (ABC) transporter-encoding gene, CnAFR1, involved in the resistance to fluconazole

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

The genetic basis of resistance to 5-fluorocytosine in Candida species and Cryptococcus neoformans

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Molecular mechanisms of drug resistance in fungi

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Starvation induces genomic rearrangements and starvation-resilient phenotypes in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Aneuploidy and isochromosome formation in drug-resistant Candida albicans

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Break-induced replication: a review and an example in budding yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

The sister chromatid cohesion pathway suppresses multiple chromosome gain and chromosome amplification.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Mutations in the multi-drug resistance regulator MRR1, followed by loss of heterozygosity, are the main cause of MDR1 overexpression in fluconazole-resistant Candida albicans strains

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Karyotypic determinants of chromosome instability in aneuploid budding yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Never in neutral: a systems biology and evolutionary perspective on how aneuploidy contributes to human diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Ploidy variation as an adaptive mechanism in human pathogenic fungi

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Azole heteroresistance in Cryptococcus neoformans: emergence of resistant clones with chromosomal disomy in the mouse brain during fluconazole treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Aneuploidy underlies a multicellular phenotypic switch

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Aneuploidy: cells losing their balance

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Deletion of Cryptococcus neoformans AIF ortholog promotes chromosome aneuploidy and fluconazole-resistance in a metacaspase-independent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Unisexual and heterosexual meiotic reproduction generate aneuploidy and phenotypic diversity de novo in the yeast Cryptococcus neoformans

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Comparative genome hybridization reveals widespread aneuploidy in Candida albicans laboratory strains.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Phylogenetic analysis of fungal ABC transporters.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

ABC transporters in Saccharomyces cerevisiae and their interactors: new technology advances the biology of the ABCC (MRP) subfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

New high-throughput screening assay to reveal similarities and differences in inhibitory sensitivities of multidrug ATP-binding cassette transporters.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Chemosensitization of fluconazole resistance in Saccharomyces cerevisiae and pathogenic fungi by a D-octapeptide derivative

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Chemosensitization prevents tolerance of Aspergillus fumigatus to antimycotic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Characterization of three classes of membrane proteins involved in fungal azole resistance by functional hyperexpression in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Inhibition of fungal ABC transporters by unnarmicin A and unnarmicin C, novel cyclic peptides from marine bacterium

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Calcineurin is essential for survival during membrane stress in Candida albicans

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Reversal of fluconazole resistance by sulfated sterols from the marine sponge Topsentia sp

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

ABC transporter Cdr1p contributes more than Cdr2p does to fluconazole efflux in fluconazole-resistant Candida albicans clinical isolates.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

A new function of isonitrile as an inhibitor of the Pdr5p multidrug ABC transporter in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Microbial fermentation-derived inhibitors of efflux-pump-mediated drug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Disulfiram is a potent modulator of multidrug transporter Cdr1p of Candida albicans

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Antifungal activity of ibuprofen alone and in combination with fluconazole against Candida species

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Quinazolinone-based fungal efflux pump inhibitors. Part 1: Discovery of an (N-methylpiperazine)-containing derivative with activity in clinically relevant Candida spp.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

In vitro interaction between azoles and cyclosporin A against clinical isolates of Candida albicans determined by the chequerboard method and time-kill curves

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

The monoamine oxidase A inhibitor clorgyline is a broad-spectrum inhibitor of fungal ABC and MFS transporter efflux pump activities which reverses the azole resistance of Candida albicans and Candida glabrata clinical isolates

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Elevated cell wall chitin in Candida albicans confers echinocandin resistance in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Characterization and cilofungin inhibition of solubilized Aspergillus fumigatus (1,3)-beta-D-glucan synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

In vitro antifungal activities and in vivo efficacies of 1,3-beta-D-glucan synthesis inhibitors L-671,329, L-646,991, tetrahydroechinocandin B, and L-687,781, a papulacandin

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Discovery of a small-molecule inhibitor of {beta}-1,6-glucan synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Antifungal activity against Candida albicans of nikkomycin Z in combination with caspofungin, voriconazole or amphotericin B.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Drug interaction studies of a glucan synthase inhibitor (LY 303366) and a chitin synthase inhibitor (Nikkomycin Z) for inhibition and killing of fungal pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

In-vitro activity of nikkomycin Z alone and in combination with polyenes, triazoles or echinocandins against Aspergillus fumigatus

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Compounds active against cell walls of medically important fungi

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Polyoxin D inhibits growth of zoopathogenic fungi

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Inhibiting GPI anchor biosynthesis in fungi stresses the endoplasmic reticulum and enhances immunogenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Efficacy of oral E1210, a new broad-spectrum antifungal with a novel mechanism of action, in murine models of candidiasis, aspergillosis, and fusariosis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Hsp90 governs dispersion and drug resistance of fungal biofilms

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Combination of caspofungin with inhibitors of the calcineurin pathway attenuates growth in vitro in Aspergillus species

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

In vitro activity of calcineurin and heat shock protein 90 Inhibitors against Aspergillus fumigatus azole- and echinocandin-resistant strains.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Antifungal activity of geldanamycin alone or in combination with fluconazole against Candida species

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Lipid formulations of amphotericin B: clinical efficacy and toxicities

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Comparison of nephrotoxicity associated to different lipid formulations of amphotericin B: a real-life study.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Efficacy and toxicity evaluation of new amphotericin B micelle systems for brain fungal infections

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Recent insights into Candida albicans biofilm resistance mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

New amphotericin B-gamma cyclodextrin formulation for topical use with synergistic activity against diverse fungal species and Leishmania spp.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Undressing the fungal cell wall/cell membrane--the antifungal drug targets.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Membrane and cell wall targets in Aspergillus fumigatus

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Fungal-specific subunits of the Candida albicans mitochondrial complex I drive diverse cell functions including cell wall synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Specific molecular features in the organization and biosynthesis of the cell wall of Aspergillus fumigatus

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Activation of caspase-like activity and poly (ADP-ribose) polymerase degradation during sporulation in Aspergillus nidulans.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

The metacaspase (Mca1p) has a dual role in farnesol-induced apoptosis in Candida albicans.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Ras pathway signaling accelerates programmed cell death in the pathogenic fungus Candida albicans

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Programmed cell death in pathogenic fungi

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Beyond serial passages: new methods for predicting the emergence of resistance to novel antibiotics.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Fitness trade-offs restrict the evolution of resistance to amphotericin B

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Use of collateral sensitivity networks to design drug cycling protocols that avoid resistance development.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Collateral Resistance and Sensitivity Modulate Evolution of High-Level Resistance to Drug Combination Treatment in Staphylococcus aureus.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Collateral sensitivity of antibiotic-resistant microbes.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Bacterial evolution of antibiotic hypersensitivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Single nuclear gene inherited cross resistance and collateral sensitivity to 17 inhibitors of mitochondrial function in S. cerevisiae.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Consensus statement on the future of mannan-binding lectin (MBL)-replacement therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Preclinical assessment of the efficacy of mycograb, a human recombinant antibody against fungal HSP90

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

Phase I evaluation of the safety and pharmacokinetics of murine-derived anticryptococcal antibody 18B7 in subjects with treated cryptococcal meningitis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2016-0051

21 January 2018

Identifiers

DOI

10.4155/FMC-2016-0051

1 reference

6 September 2017

1 reference