PHLPP phosphatases as a therapeutic target in insulin resistance-related diseases (Q38664551)

5 September 2017

title

PHLPP phosphatases as a therapeutic target in insulin resistance-related diseases (English)

1 reference

5 September 2017

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1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26652182%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26652182%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26652182%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26652182%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Marta Letizia Hribal

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26652182%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Teresa Vanessa Fiorentino

series ordinal

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9 June 2020

Giorgio Sesti

series ordinal

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26652182%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

language of work or name

English

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publication date

10 December 2015

1 reference

Expert Opinion on Therapeutic Targets

5 September 2017

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26652182%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

volume

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9 June 2020

issue

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9 June 2020

page(s)

663-675

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26652182%20AND%20SRC:MED&resulttype=core&format=json

SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus

9 June 2020

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PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

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PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms

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FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt.

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Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt.

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Scribble‐mediated membrane targeting of PHLPP1 is required for its negative regulation of Akt

21 January 2018

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PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma

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Diacylglycerol kinase δ modulates Akt phosphorylation through pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2)

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Insulin receptor kinase-independent signaling via tyrosine phosphorylation of phosphatase PHLPP1.

21 January 2018

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Serine/threonine kinase akt activation regulates the activity of retinal serine/threonine phosphatases, PHLPP and PHLPPL

21 January 2018

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mTOR-dependent regulation of PHLPP expression controls the rapamycin sensitivity in cancer cells

21 January 2018

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Histone deacetylase 3 suppression increases PH domain and leucine-rich repeat phosphatase (Phlpp)1 expression in chondrocytes to suppress Akt signaling and matrix secretion

21 January 2018

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microRNA-224 promotes cell proliferation and tumor growth in human colorectal cancer by repressing PHLPP1 and PHLPP2.

21 January 2018

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MicroRNA-141 promotes the proliferation of non-small cell lung cancer cells by regulating expression of PHLPP1 and PHLPP2.

21 January 2018

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MicroRNA-3127 promotes cell proliferation and tumorigenicity in hepatocellular carcinoma by disrupting of PI3K/AKT negative regulation

21 January 2018

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MicroRNA-331-3p promotes proliferation and metastasis of hepatocellular carcinoma by targeting PH domain and leucine-rich repeat protein phosphatase

21 January 2018

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miR-190-Mediated Downregulation of PHLPP Contributes to Arsenic-Induced Akt Activation and Carcinogenesis

21 January 2018

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NFκB1 (p50) suppresses SOD2 expression by inhibiting FoxO3a transactivation in a miR190/PHLPP1/Akt-dependent axis

21 January 2018

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NF-κB1 p50 promotes p53 protein translation through miR-190 downregulation of PHLPP1

21 January 2018

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MicroRNAs of the miR-17∼92 family are critical regulators of T(FH) differentiation

21 January 2018

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miR-205 targets PTEN and PHLPP2 to augment AKT signaling and drive malignant phenotypes in non-small cell lung cancer

21 January 2018

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miR-93 promotes cell proliferation in gliomas through activation of PI3K/Akt signaling pathway

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Exploitation of the ability of γ-tocopherol to facilitate membrane co-localization of Akt and PHLPP1 to develop PHLPP1-targeted Akt inhibitors

21 January 2018

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Guide to virtual screening: application to the Akt phosphatase PHLPP.

21 January 2018

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Discovery of small molecule inhibitors of the PH domain leucine-rich repeat protein phosphatase (PHLPP) by chemical and virtual screening

21 January 2018

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beta-TrCP-mediated ubiquitination and degradation of PHLPP1 are negatively regulated by Akt.

21 January 2018

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Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt.

21 January 2018

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Defining the human deubiquitinating enzyme interaction landscape

21 January 2018

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USP1 regulates AKT phosphorylation by modulating the stability of PHLPP1 in lung cancer cells

21 January 2018

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Deubiquitinating enzyme Usp12 regulates the interaction between the androgen receptor and the Akt pathway.

21 January 2018

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The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer

21 January 2018

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WD repeat protein WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1)

21 January 2018

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The de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signaling

21 January 2018

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The N-terminal region of p27 inhibits HIF-1α protein translation in ribosomal protein S6-dependent manner by regulating PHLPP-Ras-ERK-p90RSK axis

21 January 2018

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Crucial role of c-Jun phosphorylation at Ser63/73 mediated by PHLPP protein degradation in the cheliensisin a inhibition of cell transformation

21 January 2018

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The phosphatase PHLPP controls the cellular levels of protein kinase C

21 January 2018

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PHLPP-mediated dephosphorylation of S6K1 inhibits protein translation and cell growth

21 January 2018

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Mst1 is an interacting protein that mediates PHLPPs' induced apoptosis

21 January 2018

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Suprachiasmatic nucleus circadian oscillatory protein, a novel binding partner of K-Ras in the membrane rafts, negatively regulates MAPK pathway

21 January 2018

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Proteolytic degradation of SCOP in the hippocampus contributes to activation of MAP kinase and memory

21 January 2018

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Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output.

21 January 2018

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Structure, regulation and function of PKB/AKT--a major therapeutic target

21 January 2018

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Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt.

21 January 2018

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FKBP5 as a selection biomarker for gemcitabine and Akt inhibitors in treatment of pancreatic cancer

21 January 2018

1 reference

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Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients

21 January 2018

1 reference

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Lipid activation of protein kinases

21 January 2018

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Active Site Inhibitors Protect Protein Kinase C from Dephosphorylation and Stabilize Its Mature Form

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2016.1130822

Molecular mechanisms of insulin resistance: serine phosphorylation of insulin receptor substrate-1 and increased expression of p85alpha: the two sides of a coin

21 January 2018

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Biosignaling of mammalian Ste20-related kinases

21 January 2018

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AP-1/c-Jun transcription factors: regulation and function in malignant melanoma

21 January 2018

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Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.

21 January 2018

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PHLPP-1 negatively regulates Akt activity and survival in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1130822

Physiological activation of Akt by PHLPP1 deletion protects against pathological hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1130822

Activation of PH-domain leucine-rich protein phosphatase 2 (PHLPP2) by agonist stimulation in cardiac myocytes expressing adenylyl cyclase type 6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1130822

PHLPP1 gene deletion protects the brain from ischemic injury

21 January 2018

1 reference

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Increased levels of the Akt-specific phosphatase PH domain leucine-rich repeat protein phosphatase (PHLPP)-1 in obese participants are associated with insulin resistance.

21 January 2018

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Glucose tolerance, insulin sensitivity and insulin release in European non-diabetic carriers of a polymorphism upstream of CDKN2A and CDKN2B.

21 January 2018

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Protein phosphatase PHLPP1 controls the light-induced resetting of the circadian clock

21 January 2018

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The impact of sleep disorders on glucose metabolism: endocrine and molecular mechanisms

21 January 2018

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Light activation of the insulin receptor regulates mitochondrial hexokinase. A possible mechanism of retinal neuroprotection

21 January 2018

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Photoreceptors in diabetic retinopathy

21 January 2018

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Genome-wide association with diabetes-related traits in the Framingham Heart Study

21 January 2018

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Association of POL1, MALT1, MC4R, PHLPP and DSEL single nucleotide polymorphisms in chromosome 18q region with type 2 diabetes in Tunisians

21 January 2018

1 reference

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Common polymorphism in the phosphatase PHLPP2 results in reduced regulation of Akt and protein kinase C.

21 January 2018

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Identification of pharmacogenetic markers in smoking cessation therapy

21 January 2018

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Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population

21 January 2018

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Biological, clinical and population relevance of 95 loci for blood lipids

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2016.1130822

Discovery and refinement of loci associated with lipid levels

21 January 2018

1 reference

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Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1130822

Pleckstrin homology domain leucine-rich repeat protein phosphatase (PHLPP): a new player in cell signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2016.1130822

Selective insulin and leptin resistance in metabolic disorders

21 January 2018

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10.1517/14728222.2016.1130822

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26652182%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26652182%20AND%20SRC:MED&resulttype=core&format=json