Increased levels of the Akt-specific phosphatase PH domain leucine-rich repeat protein phosphatase (PHLPP)-1 in obese participants are associated with insulin resistance. (Q39565163)

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scientific article published on April 2011

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English	Increased levels of the Akt-specific phosphatase PH domain leucine-rich repeat protein phosphatase (PHLPP)-1 in obese participants are associated with insulin resistance.	scientific article published on April 2011

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27 January 2020

Increased levels of the Akt-specific phosphatase PH domain leucine-rich repeat protein phosphatase (PHLPP)-1 in obese participants are associated with insulin resistance (English)

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27 January 2020

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insulin resistance

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Francesco Andreozzi

1

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27 January 2020

Gaia Chiara Mannino

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27 January 2020

Gregoryalexander Raciti

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27 January 2020

11

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27 January 2020

12

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27 January 2020

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C Procopio

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27 January 2020

A Greco

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27 January 2020

C Miele

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27 January 2020

C Iadicicco

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27 January 2020

F Beguinot

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27 January 2020

A E Pontiroli

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27 January 2020

M L Hribal

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27 January 2020

publication date

1 April 2011

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27 January 2020

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9

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27 January 2020

54

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27 January 2020

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27 January 2020

1879-1887

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27 January 2020

Molecular mechanism of insulin resistance in type 2 diabetes mellitus: role of the insulin receptor variant forms

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21 January 2018

Pathophysiology of insulin resistance.

1 reference

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21 January 2018

Critical nodes in signalling pathways: insights into insulin action

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2116-6

21 January 2018

Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus

1 reference

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21 January 2018

Physiological and molecular determinants of insulin action in the baboon.

1 reference

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21 January 2018

Increased expression of insulin/insulin-like growth factor-I hybrid receptors in skeletal muscle of noninsulin-dependent diabetes mellitus subjects

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2116-6

21 January 2018

Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2116-6

21 January 2018

Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance of noninsulin-dependent diabetes mellitus and obesity.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2116-6

21 January 2018

Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2116-6

21 January 2018

Defects of the insulin receptor substrate (IRS) system in human metabolic disorders

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21 January 2018

Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential

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21 January 2018

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

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21 January 2018

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

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21 January 2018

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

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21 January 2018

Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation

1 reference

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21 January 2018

Activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: amelioration by rosiglitazone and exercise

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2116-6

21 January 2018

Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2116-6

21 January 2018

Insulin-stimulated protein kinase C lambda/zeta activity is reduced in skeletal muscle of humans with obesity and type 2 diabetes: reversal with weight reduction

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2116-6

21 January 2018

Impaired activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 in cultured preadipocyte-derived adipocytes and myotubes of obese subjects

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2116-6

21 January 2018

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2116-6

21 January 2018

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2116-6

21 January 2018

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2116-6

21 January 2018

siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2116-6

21 January 2018

Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2116-6

21 January 2018

Defective signaling through Akt-2 and -3 but not Akt-1 in insulin-resistant human skeletal muscle: potential role in insulin resistance

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2116-6

21 January 2018

Impaired expression and insulin-stimulated phosphorylation of Akt-2 in muscle of obese patients with atypical diabetes

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2116-6

21 January 2018

Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2116-6

21 January 2018

PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2116-6

21 January 2018

PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2116-6

21 January 2018

Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

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21 January 2018

Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells.

1 reference

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21 January 2018

Defective insulin receptor tyrosine kinase in human skeletal muscle in obesity and type 2 (non-insulin-dependent) diabetes mellitus

1 reference

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PHLPPing it off: phosphatases get in the Akt

1 reference

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Insulin-receptor kinase activity of adipose tissue from morbidly obese humans with and without NIDDM.

1 reference

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Diagnosis and Classification of Diabetes Mellitus

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Increased abundance of insulin/insulin-like growth factor-I hybrid receptors in skeletal muscle of obese subjects is correlated with in vivo insulin sensitivity

1 reference

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12 December 2020

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Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects

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Impaired phosphorylation and insulin-stimulated translocation to the plasma membrane of protein kinase B/Akt in adipocytes from Type II diabetic subjects

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Impaired autophosphorylation of insulin receptors from abdominal skeletal muscles in nonobese subjects with NIDDM.

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