Critical nodes in signalling pathways: insights into insulin action (Q29614735)

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=16493415

30 April 2017

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Kahn CR

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30 April 2017

Taniguchi CM

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=16493415

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=16493415

30 April 2017

Emanuelli B

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30 April 2017

language of work or name

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30 April 2017

publication date

February 2006

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Nature Reviews Molecular Cell Biology

30 April 2017

published in

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30 April 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=16493415

30 April 2017

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30 April 2017

page(s)

85-96

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Insulin signal transduction through protein kinase cascades

30 April 2017

cites work

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Signal transduction by receptors with tyrosine kinase activity

31 March 2020

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Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene

31 March 2020

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Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms

31 March 2020

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SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice

31 March 2020

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Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

31 March 2020

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Role of IRS-2 in insulin and cytokine signalling

31 March 2020

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The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family

31 March 2020

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Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells

31 March 2020

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Two New Substrates in Insulin Signaling, IRS5/DOK4 and IRS6/DOK5

31 March 2020

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Identification of major tyrosine phosphorylation sites in the human insulin receptor substrate Gab-1 by insulin receptor kinase in vitro

31 March 2020

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CAP defines a second signalling pathway required for insulin-stimulated glucose transport

31 March 2020

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Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain

31 March 2020

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Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance

31 March 2020

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The COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signaling

31 March 2020

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Insulin receptor substrate proteins create a link between the tyrosine phosphorylation cascade and the Ca2+-ATPases in muscle and heart

31 March 2020

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Association of insulin receptor substrate 1 with simian virus 40 large T antigen

31 March 2020

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Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes

31 March 2020

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The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

31 March 2020

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Activation of cJun NH2-terminal kinase/stress-activated protein kinase by insulin

31 March 2020

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Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

31 March 2020

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A central role for JNK in obesity and insulin resistance

31 March 2020

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The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)

31 March 2020

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14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner

31 March 2020

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Deletion of Gab1 in the liver leads to enhanced glucose tolerance and improved hepatic insulin action

31 March 2020

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Insulin down-regulates insulin receptor substrate-2 expression through the phosphatidylinositol 3-kinase/Akt pathway

31 March 2020

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SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2

31 March 2020

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Defects of the insulin receptor substrate (IRS) system in human metabolic disorders

31 March 2020

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Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

31 March 2020

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Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus

31 March 2020

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Disruption of IRS-2 causes type 2 diabetes in mice

31 March 2020

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Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin

31 March 2020

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Essential role of insulin receptor substrate 1 (IRS-1) and IRS-2 in adipocyte differentiation

31 March 2020

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Differential contribution of insulin receptor substrates 1 versus 2 to insulin signaling and glucose uptake in l6 myotubes.

31 March 2020

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Complementary roles of IRS-1 and IRS-2 in the hepatic regulation of metabolism

31 March 2020

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The IRS-2 gene on murine chromosome 8 encodes a unique signaling adapter for insulin and cytokine action.

31 March 2020

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Insulin substrates 1 and 2 are corequired for activation of atypical protein kinase C and Cbl-dependent phosphatidylinositol 3-kinase during insulin action in immortalized brown adipocytes

31 March 2020

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Insulin receptor substrate 3 (IRS-3) and IRS-4 impair IRS-1- and IRS-2-mediated signaling

31 March 2020

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Dynamics of insulin signaling in 3T3-L1 adipocytes. Differential compartmentalization and trafficking of insulin receptor substrate (IRS)-1 and IRS-2.

31 March 2020

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Insulin receptor substrate (IRS)-2 is dephosphorylated more rapidly than IRS-1 via its association with phosphatidylinositol 3-kinase in skeletal muscle cells

31 March 2020

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Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786

31 March 2020

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IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85

31 March 2020

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Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

31 March 2020

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha

31 March 2020

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Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

31 March 2020

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

31 March 2020

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PTEN: a tumour suppressor that functions as a phospholipid phosphatase

31 March 2020

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Muscle-specific Pten deletion protects against insulin resistance and diabetes

31 March 2020

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PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes

31 March 2020

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Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity

31 March 2020

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Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling

31 March 2020

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Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit

31 March 2020

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p110beta is up-regulated during differentiation of 3T3-L1 cells and contributes to the highly insulin-responsive glucose transport activity

31 March 2020

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Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of phosphatidylinositol 3-kinase

31 March 2020

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Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain

31 March 2020

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Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase

31 March 2020

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Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

31 March 2020

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p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity

31 March 2020

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Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha

31 March 2020

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Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

31 March 2020

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Human placental growth hormone increases expression of the p85 regulatory unit of phosphatidylinositol 3-kinase and triggers severe insulin resistance in skeletal muscle

31 March 2020

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Increased p85/55/50 expression and decreased phosphotidylinositol 3-kinase activity in insulin-resistant human skeletal muscle

31 March 2020

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Positive and negative regulation of phosphoinositide 3-kinase-dependent signaling pathways by three different gene products of the p85alpha regulatory subunit

31 March 2020

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The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex

31 March 2020

1 reference

Positive and Negative Roles of p85α and p85β Regulatory Subunits of Phosphoinositide 3-Kinase in Insulin Signaling

31 March 2020

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31 March 2020

Phosphoinositide kinases

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Proteolysis-independent regulation of PI3K by Cbl-b-mediated ubiquitination in T cells.

31 March 2020

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

31 March 2020

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Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation

31 March 2020

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Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

31 March 2020

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The forkhead transcription factor Foxo1 regulates adipocyte differentiation

31 March 2020

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Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes.

31 March 2020

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Advances in protein kinase B signalling: AKTion on multiple fronts

31 March 2020

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PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

31 March 2020

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TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver

31 March 2020

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PGC-1 promotes insulin resistance in liver through PPAR-alpha-dependent induction of TRB-3.

31 March 2020

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Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

31 March 2020

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Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

31 March 2020

1 reference

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

31 March 2020

1 reference

A family with severe insulin resistance and diabetes due to a mutation in AKT2.

31 March 2020

1 reference

Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis

31 March 2020

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AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation

31 March 2020

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Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B.

31 March 2020

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Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing

31 March 2020

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Insulin increases the association of Akt-2 with Glut4-containing vesicles

31 March 2020

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Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles

31 March 2020

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Molecular cloning, expression and characterization of the human serine/threonine kinase Akt-3

31 March 2020

1 reference

Insulin and PIP3 activate PKC-zeta by mechanisms that are both dependent and independent of phosphorylation of activation loop (T410) and autophosphorylation (T560) sites

31 March 2020

1 reference

Function and dysfunction of aPKC isoforms for glucose transport in insulin-sensitive and insulin-resistant states

31 March 2020

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Atypical protein kinase C in insulin action and insulin resistance

31 March 2020

1 reference

Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling

31 March 2020

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Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice

31 March 2020

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The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis

31 March 2020

1 reference

Ras plasma membrane signalling platforms

31 March 2020

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Phosphatidylinositol-3-OH kinase as a direct target of Ras

31 March 2020

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The RAF proteins take centre stage

31 March 2020

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Small GTPase Rac1: structure, localization, and expression of the human gene.

31 March 2020

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Genomic organization and chromosomal location of murine Cdc42.

31 March 2020

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The GTP-binding protein Rac does not couple PI 3-kinase to insulin-stimulated glucose transport in adipocytes

31 March 2020

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Cdc42 is a Rho GTPase family member that can mediate insulin signaling to glucose transport in 3T3-L1 adipocytes

31 March 2020

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Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development

31 March 2020

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Activation and signaling of the p38 MAP kinase pathway

31 March 2020

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Activation of the glucose transporter GLUT4 by insulin

31 March 2020

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Enhanced basal activation of mitogen-activated protein kinases in adipocytes from type 2 diabetes: potential role of p38 in the downregulation of GLUT4 expression.

31 March 2020

1 reference

TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport

31 March 2020

1 reference

Cbl: many adaptations to regulate protein tyrosine kinases

31 March 2020

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c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action

31 March 2020

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Analysis of insulin signalling by RNAi-based gene silencing

31 March 2020

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A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells

31 March 2020

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Generation of Ski-knockdown mice by expressing a long double-strand RNA from an RNA polymerase II promoter.

31 March 2020

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Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice

31 March 2020

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Insulin receptor structure and function in normal and pathological conditions

31 March 2020

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Separate domains of the insulin receptor contain sites of autophosphorylation and tyrosine kinase activity

31 March 2020

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Tissue-specific expression of two alternatively spliced isoforms of the human insulin receptor protein.

31 March 2020

1 reference

Functional properties of two naturally occurring isoforms of the human insulin receptor in Chinese hamster ovary cells

31 March 2020

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Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells

31 March 2020

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Emergent properties of networks of biological signaling pathways

31 March 2020

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=16493415

31 March 2020

Identifiers

2 references

30 April 2017

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2843563

Dimensions Publication ID

1000054376

0 references

OpenCitations bibliographic resource ID

2843563

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2843563

PubMed publication ID

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=16493415