Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients (Q46801587)

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English	Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients	scientific article

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Europe PubMed Central

PubMed publication ID

18204829

retrieved

25 December 2017

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http://europepmc.org/abstract/MED/18204829

title

Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients (English)

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Europe PubMed Central

PubMed publication ID

18204829

retrieved

25 December 2017

reference URL

http://europepmc.org/abstract/MED/18204829

main subject

preproinsulin

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based on heuristic

inferred from title

skeletal muscle cell

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based on heuristic

inferred from title

author

Luciano Pirola

series ordinal

6

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Europe PubMed Central

PubMed publication ID

18204829

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25 December 2017

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http://europepmc.org/abstract/MED/18204829

author name string

D Cozzone

series ordinal

1

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Europe PubMed Central

PubMed publication ID

18204829

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25 December 2017

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http://europepmc.org/abstract/MED/18204829

S Fröjdö

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2

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Europe PubMed Central

PubMed publication ID

18204829

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25 December 2017

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http://europepmc.org/abstract/MED/18204829

E Disse

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3

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Europe PubMed Central

PubMed publication ID

18204829

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25 December 2017

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http://europepmc.org/abstract/MED/18204829

C Debard

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4

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Europe PubMed Central

PubMed publication ID

18204829

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25 December 2017

reference URL

http://europepmc.org/abstract/MED/18204829

M Laville

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5

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Europe PubMed Central

PubMed publication ID

18204829

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25 December 2017

reference URL

http://europepmc.org/abstract/MED/18204829

H Vidal

series ordinal

7

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Europe PubMed Central

PubMed publication ID

18204829

retrieved

25 December 2017

reference URL

http://europepmc.org/abstract/MED/18204829

publication date

18 January 2008

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Europe PubMed Central

PubMed publication ID

18204829

retrieved

25 December 2017

reference URL

http://europepmc.org/abstract/MED/18204829

published in

Diabetologia

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Europe PubMed Central

PubMed publication ID

18204829

retrieved

25 December 2017

reference URL

http://europepmc.org/abstract/MED/18204829

volume

51

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Europe PubMed Central

PubMed publication ID

18204829

retrieved

25 December 2017

reference URL

http://europepmc.org/abstract/MED/18204829

issue

3

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Europe PubMed Central

PubMed publication ID

18204829

retrieved

25 December 2017

reference URL

http://europepmc.org/abstract/MED/18204829

page(s)

512-521

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Europe PubMed Central

PubMed publication ID

18204829

retrieved

25 December 2017

reference URL

http://europepmc.org/abstract/MED/18204829

cites work

Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18204829

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12 December 2020

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inferred from PubMed ID database lookup

Functional studies of Akt isoform specificity in skeletal muscle in vivo; maintained insulin sensitivity despite reduced insulin receptor substrate-1 expression

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18204829

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12 December 2020

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Mechanism of activation of protein kinase B by insulin and IGF-1

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18204829

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12 December 2020

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Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18204829

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12 December 2020

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siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18204829

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12 December 2020

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inferred from PubMed ID database lookup

Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18204829

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12 December 2020

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Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18204829

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12 December 2020

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Acute regulation by insulin of phosphatidylinositol-3-kinase, Rad, Glut 4, and lipoprotein lipase mRNA levels in human muscle

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18204829

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12 December 2020

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18204829

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12 December 2020

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Role for Akt3/protein kinase Bgamma in attainment of normal brain size

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18204829

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12 December 2020

based on heuristic

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Activation of liver X receptors promotes lipid accumulation but does not alter insulin action in human skeletal muscle cells.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18204829

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18204829

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of Akt/protein kinase B in metabolism.

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18204829

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12 December 2020

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inferred from PubMed ID database lookup

Defective signaling through Akt-2 and -3 but not Akt-1 in insulin-resistant human skeletal muscle: potential role in insulin resistance

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18204829

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12 December 2020

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inferred from PubMed ID database lookup

Insulin signalling in skeletal muscle of subjects with or without Type II-diabetes and first degree relatives of patients with the disease

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18204829

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12 December 2020

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Expression of key genes of fatty acid oxidation, including adiponectin receptors, in skeletal muscle of Type 2 diabetic patients

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18204829

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12 December 2020

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inferred from PubMed ID database lookup

Synergistic interaction between exercise and insulin on peripheral glucose uptake

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18204829

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12 December 2020

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Insulin action and glucose metabolism in nondiabetic control and NIDDM subjects. Comparison using human skeletal muscle cell cultures

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18204829

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12 December 2020

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Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18204829

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12 December 2020

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PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18204829

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12 December 2020

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3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18204829

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12 December 2020

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Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18204829

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12 December 2020

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Structure, regulation and function of PKB/AKT--a major therapeutic target

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18204829

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Decreased insulin responsiveness of glucose uptake in cultured human skeletal muscle cells from insulin-resistant nondiabetic relatives of type 2 diabetic families

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18204829

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycogen synthase activity is reduced in cultured skeletal muscle cells of non-insulin-dependent diabetes mellitus subjects. Biochemical and molecular mechanisms

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18204829

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased p85/55/50 expression and decreased phosphotidylinositol 3-kinase activity in insulin-resistant human skeletal muscle

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18204829

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired muscle glycogen synthase in type 2 diabetes is associated with diminished phosphatidylinositol 3-kinase activation

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18204829

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4,5-(PO4)3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: amelioration by rosiglitazone and exercise

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18204829

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle

1 reference

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18204829

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation by insulin of gene expression in human skeletal muscle and adipose tissue. Evidence for specific defects in type 2 diabetes.

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18204829

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The insulin signalling system and the IRS proteins

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18204829

retrieved

12 December 2020

based on heuristic

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The diabetic phenotype is conserved in myotubes established from diabetic subjects: evidence for primary defects in glucose transport and glycogen synthase activity

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PubMed

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https://pubmed.ncbi.nlm.nih.gov/18204829

retrieved

12 December 2020

based on heuristic

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The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18204829

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18204829

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resveratrol is a class IA phosphoinositide 3-kinase inhibitor

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18204829

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced activation of phosphatidylinositol-3 kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18204829

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes

1 reference

stated in

PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18204829

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase B/Akt at a glance

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18204829

retrieved

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

DOI

10.1007/S00125-007-0913-8

1 reference

stated in

Europe PubMed Central

PubMed publication ID

18204829

retrieved

25 December 2017

reference URL

http://europepmc.org/abstract/MED/18204829

PubMed publication ID

18204829

1 reference

stated in

Europe PubMed Central

PubMed publication ID

18204829

retrieved

25 December 2017

reference URL

http://europepmc.org/abstract/MED/18204829

ResearchGate publication ID

5646450

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