From crystal to compound: structure-based antimalarial drug discovery (Q38227796)

https://api.crossref.org/works/10.1042%2FBJ20140240

Plasmodium dominicana n. sp. (Plasmodiidae: Haemospororida) from Tertiary Dominican amber

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Traditional herbal medicines for malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Reflections on the 'discovery' of the antimalarial qinghao

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Ancient Chinese methods are remarkably effective for the preparation of artemisinin-rich extracts of Qing Hao with potent antimalarial activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Malaria, a journey in time: in search of the lost myths and forgotten stories

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Artemisinin Resistance in Plasmodium falciparum Malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Evidence of Artemisinin-Resistant Malaria in Western Cambodia

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Artemisinin-resistant malaria in Asia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

A major genome region underlying artemisinin resistance in malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Novel approaches in antimalarial drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Antimalarial drug discovery - approaches and progress towards new medicines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Molecular Basis for Drug Resistance in HIV-1 Protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Drug resistance against HCV NS3/4A inhibitors is defined by the balance of substrate recognition versus inhibitor binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

New targets, new hope: novel drug targets for curbing malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

The state of the art in anti-malarial drug discovery and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Thousands of chemical starting points for antimalarial lead identification

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Chemical genetics of Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Spiroindolones, a potent compound class for the treatment of malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Primaquine therapy for malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

A pre-emptive strike against malaria's stealthy hepatic forms

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

The next opportunity in anti-malaria drug discovery: the liver stage

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Redefining the role of de novo fatty acid synthesis in Plasmodium parasites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Type II fatty acid synthesis is essential only for malaria parasite late liver stage development

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

The caspase-1 inflammasome: a pilot of innate immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

The multienzyme architecture of eukaryotic fatty acid synthases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Escherichia coli as a model for the regulation of dissociable (type II) fatty acid biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

'FAS't inhibition of malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Structural basis for catalytic and inhibitory mechanisms of beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ)

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

The crystal structure of PfFabZ, the unique beta-hydroxyacyl-ACP dehydratase involved in fatty acid biosynthesis of Plasmodium falciparum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Identification, characterization, and inhibition of Plasmodium falciparum beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ).

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Synthesis and biological evaluation of NAS-21 and NAS-91 analogues as potential inhibitors of the mycobacterial FAS-II dehydratase enzyme Rv0636.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Antimycobacterial Activity and Mechanism of Action of NAS-91

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Structural basis for the functional and inhibitory mechanisms of β-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Novel diphenyl ethers: design, docking studies, synthesis and inhibition of enoyl ACP reductase of Plasmodium falciparum and Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-substituted triclosan derivatives.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2'-substituted triclosan derivatives.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Design, synthesis, and biological and crystallographic evaluation of novel inhibitors of Plasmodium falciparum enoyl-ACP-reductase (PfFabI)

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Privileged structures: applications in drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Structure of 2C-methyl-D-erythritol 2,4- cyclodiphosphate synthase: an essential enzyme for isoprenoid biosynthesis and target for antimicrobial drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Sterol molecule: structure, biosynthesis, and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Isoprenoid biosynthesis in bacteria: a novel pathway for the early steps leading to isopentenyl diphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Functional genetic analysis of the Plasmodium falciparum deoxyxylulose 5-phosphate reductoisomerase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Active isoprenoid pathway in the intra-erythrocytic stages of Plasmodium falciparum: presence of dolichols of 11 and 12 isoprene units

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

21 January 2018

Fosmidomycin for malaria

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Fosmidomycin, a novel chemotherapeutic agent for malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Fosmidomycin-clindamycin for the treatment of Plasmodium falciparum malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Synthesis of beta- and gamma-oxa isosteres of fosmidomycin and FR900098 as antimalarial candidates

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Antimalarial and Structural Studies of Pyridine-Containing Inhibitors of 1-Deoxyxylulose-5-phosphate Reductoisomerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Molecular basis of fosmidomycin's action on the human malaria parasite Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Reverse fosmidomycin derivatives against the antimalarial drug target IspC (Dxr)

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Structures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate Complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

IspC as target for antiinfective drug discovery: synthesis, enantiomeric separation, and structural biology of fosmidomycin thia isosters

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

A class of potent antimalarials and their specific accumulation in infected erythrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Disruption of the Plasmodium falciparum PfPMT gene results in a complete loss of phosphatidylcholine biosynthesis via the serine-decarboxylase-phosphoethanolamine-methyltransferase pathway and severe growth and survival defects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

In vivo evidence for the specificity of Plasmodium falciparum phosphoethanolamine methyltransferase and its coupling to the Kennedy pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Biochemical and genetic analysis of the phosphoethanolamine methyltransferase of the human malaria parasite Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

A pathway for phosphatidylcholine biosynthesis in Plasmodium falciparum involving phosphoethanolamine methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Phosphoethanolamine methyltransferases in phosphocholine biosynthesis: functions and potential for antiparasite therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Identification of inhibitors of Plasmodium falciparum phosphoethanolamine methyltransferase using an enzyme-coupled transmethylation assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Thermodynamic Evaluation of Ligand Binding in the Plant-like Phosphoethanolamine Methyltransferases of the Parasitic Nematode Haemonchus contortus

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Structure and Reaction Mechanism of Phosphoethanolamine Methyltransferase from the Malaria Parasite Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Crystal structure of phosphoethanolamine methyltransferase from Plasmodium falciparum in complex with amodiaquine

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Plasmodium falciparum phosphoethanolamine methyltransferase is essential for malaria transmission

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Targeting a novel Plasmodium falciparum purine recycling pathway with specific immucillins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Inhibitors of the purine salvage pathway: a valuable approach for antiprotozoal chemotherapy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Transition-state analogs as inhibitors of human and malarial hypoxanthine-guanine phosphoribosyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Acyclic Immucillin Phosphonates: Second-Generation Inhibitors of Plasmodium falciparum Hypoxanthine- Guanine-Xanthine Phosphoribosyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

The 2.0 A structure of malarial purine phosphoribosyltransferase in complex with a transition-state analogue inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

The 2.0 A structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: a target for anti-malarial chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, Plasmodium falciparum and Plasmodium vivax 6-oxopurine phosphoribosyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Prodrugs of phosphates and phosphonates

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Purine and Pyrimidine Pathways as Targets in Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Purine-less death in Plasmodium falciparum induced by immucillin-H, a transition state analogue of purine nucleoside phosphorylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Purine and pyrimidine transport in pathogenic protozoa: from biology to therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Enzymes of purine and pyrimidine metabolism from the human malaria parasite, Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Atomic dissection of the hydrogen bond network for transition-state analogue binding to purine nucleoside phosphorylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Neighboring Group Participation in the Transition State of Human Purine Nucleoside Phosphorylase †

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Transition-state interactions revealed in purine nucleoside phosphorylase by binding isotope effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

l -Enantiomers of Transition State Analogue Inhibitors Bound to Human Purine Nucleoside Phosphorylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Structural basis for the decarboxylation of orotidine 5'-monophosphate (OMP) by Plasmodium falciparum OMP decarboxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

The in silico screening and X-ray structure analysis of the inhibitor complex of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Classification of chemical compounds by protein-compound docking for use in designing a focused library.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Primary structure of the gene encoding the bifunctional dihydrofolate reductase-thymidylate synthase of Leishmania major

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Preclinical Evaluation of the Antifolate QN254, 5-Chloro- N'6'-(2,5-Dimethoxy-Benzyl)-Quinazoline-2,4,6-Triamine, as an Antimalarial Drug Candidate

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Implications of protein flexibility for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

New approaches to HIV protease inhibitor drug design II: testing the substrate envelope hypothesis to avoid drug resistance and discover robust inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Mutational, inhibitory and microcalorimetric analyses of Plasmodium falciparum TMP kinase. Implications for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Structural basis for the efficient phosphorylation of AZT-MP (3'-azido-3'-deoxythymidine monophosphate) and dGMP by Plasmodium falciparum type I thymidylate kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Potential application of thymidylate kinase in nucleoside analogue activation in Plasmodium falciparum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Synthesis and Evaluation of α-Thymidine Analogues as Novel Antimalarials

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Rational design of 5'-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacterial growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Keeping uracil out of DNA: physiological role, structure and catalytic mechanism of dUTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Leishmania major

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Lethality of a dut (deoxyuridine triphosphatase) mutation in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Design, synthesis and evaluation of novel uracil acetamide derivatives as potential inhibitors of Plasmodium falciparum dUTP nucleotidohydrolase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

β-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Structural Plasticity of Malaria Dihydroorotate Dehydrogenase Allows Selective Binding of Diverse Chemical Scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Novel Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Anti-malarial Activity in the Mouse Model

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Factors influencing the specificity of inhibitor binding to the human and malaria parasite dihydroorotate dehydrogenases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Structure of Plasmodium falciparum dihydroorotate dehydrogenase with a bound inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

N-myristoyltransferase: a prospective drug target for protozoan parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Selective inhibitors of protozoan protein N-myristoyltransferases as starting points for tropical disease medicinal chemistry programs

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Discovery of Plasmodium vivax N -Myristoyltransferase Inhibitors: Screening, Synthesis, and Structural Characterization of their Binding Mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Design and Synthesis of Inhibitors of Plasmodium falciparumN -Myristoyltransferase, A Promising Target for Antimalarial Drug Discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Discovery of Novel and Ligand-Efficient Inhibitors of Plasmodium falciparum and Plasmodium vivax N -Myristoyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N -Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (LELP)

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Structure of the MTIP-MyoA complex, a key component of the malaria parasite invasion motor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

The closed MTIP-myosin A-tail complex from the malaria parasite invasion machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Structure-based design of novel small-molecule inhibitors of Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

ZINC--a free database of commercially available compounds for virtual screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Interaction between Plasmodium falciparum apical membrane antigen 1 and the rhoptry neck protein complex defines a key step in the erythrocyte invasion process of malaria parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Apical membrane antigen 1 as an anti-malarial drug target

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Structure of AMA1 from Plasmodium falciparum reveals a clustering of polymorphisms that surround a conserved hydrophobic pocket

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Peptide inhibitors of the malaria surface protein, apical membrane antigen 1: identification of key binding residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Structural and Functional Insights into the Malaria Parasite Moving Junction Complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Disrupting malaria parasite AMA1-RON2 interaction with a small molecule prevents erythrocyte invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Malarial proteases and host cell egress: an 'emerging' cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

In Silico screening on the three-dimensional model of the Plasmodium vivax SUB1 protease leads to the validation of a novel anti-parasite compound

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Plasmodium subtilisin-like protease 1 (SUB1): insights into the active-site structure, specificity and function of a pan-malaria drug target.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

BTS1 Encodes a Geranylgeranyl Diphosphate Synthase in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Protein prenyl transferase activities of Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Molecular Characterization of a Novel Geranylgeranyl Pyrophosphate Synthase from Plasmodium Parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Bisphosphonate inhibition of a Plasmodium farnesyl diphosphate synthase and a general method for predicting cell-based activity from enzyme data

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Emerging principles in protease-based drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Biological roles of proteases in parasitic protozoa

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

A distinct member of the aspartic proteinase gene family from the human malaria parasite Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Order and specificity of the Plasmodium falciparum hemoglobin degradation pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Development of protease inhibitors for protozoan infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Functional profiling, identification, and inhibition of plasmepsins in intraerythrocytic malaria parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Recombinant Plasmepsin 1 from the Human Malaria Parasite Plasmodium falciparum : Enzymatic Characterization, Active Site Inhibitor Design, and Structural Analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Structural studies of vacuolar plasmepsins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Structure of the aspartic protease plasmepsin 4 from the malarial parasite Plasmodium malariae bound to an allophenylnorstatine-based inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

High-affinity inhibition of a family of Plasmodium falciparum proteases by a designed adaptive inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Crystal structures of the free and inhibited forms of plasmepsin I (PMI) from Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Crystal Structures of the Histo-Aspartic Protease (HAP) from Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Structural Insights into the Activation and Inhibition of Histo-Aspartic Protease from Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Identification of plasmepsin inhibitors as selective anti-malarial agents using ligand based drug design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Plasmodium falciparum cysteine protease falcipain-1 is not essential in erythrocytic stage malaria parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Structures of Falcipain-2 and Falcipain-3 Bound to Small Molecule Inhibitors: Implications for Substrate Specificity ‡

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Falcipain inhibition as a promising antimalarial target

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Development of Plasmodium falciparum protease inhibitors in the past decade (2002-2012).

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Synthesis, biological evaluation, hydration site thermodynamics, and chemical reactivity analysis of α-keto substituted peptidomimetics for the inhibition of Plasmodium falciparum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Total synthesis, stereochemical assignment, and antimalarial activity of gallinamide A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Symplocamide A, a potent cytotoxin and chymotrypsin inhibitor from the marine Cyanobacterium Symploca sp

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

The antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipains

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

A Plasmodium falciparum dipeptidyl aminopeptidase I participates in vacuolar hemoglobin degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Functional studies of Plasmodium falciparum dipeptidyl aminopeptidase I using small molecule inhibitors and active site probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Plasmodium dipeptidyl aminopeptidases as malaria transmission-blocking drug targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Roles for two aminopeptidases in vacuolar hemoglobin catabolism in Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Hemoglobin degradation in the malaria parasite Plasmodium falciparum: an ordered process in a unique organelle

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Hydrolysis of erythrocyte proteins by proteases of malaria parasites

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Downstream effects of haemoglobinase inhibition in Plasmodium falciparum-infected erythrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

The M18 aspartyl aminopeptidase of the human malaria parasite Plasmodium falciparum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Identification of phosphinate dipeptide analog inhibitors directed against the Plasmodium falciparum M17 leucine aminopeptidase as lead antimalarial compounds.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Synthesis and structure-activity relationships of phosphonic arginine mimetics as inhibitors of the M1 and M17 aminopeptidases from Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Fingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Development of bestatin-based activity-based probes for metallo-aminopeptidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Synthesis of New (−)-Bestatin-Based Inhibitor Libraries Reveals a Novel Binding Mode in the S1 Pocket of the Essential Malaria M1 Metalloaminopeptidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Structure-activity relationships and blood distribution of antiplasmodial aminopeptidase-1 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

X-ray crystal structure and specificity of the Plasmodium falciparum malaria aminopeptidase PfM18AAP

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Drug discovery: Priming the antimalarial pipeline

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Feeding the Antimalarial Pipeline

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Plasmodium falciparum glycogen synthase kinase-3: molecular model, expression, intracellular localisation and selective inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Bioinformatic analysis of glycogen synthase kinase 3: human versus parasite kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

3,6-Diamino-4-(2-halophenyl)-2-benzoylthieno[2,3-b]pyridine-5-carbonitriles are selective inhibitors of Plasmodium falciparum glycogen synthase kinase-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Roles of peptidyl-prolyl cis-trans isomerase and calcineurin in the mechanisms of antimalarial action of cyclosporin A, FK506, and rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

A bifunctional molecule that displays context-dependent cellular activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Structural Insights into Substrate Binding by PvFKBP35, a Peptidylprolyl cis-trans Isomerase from the Human Malarial Parasite Plasmodium vivax

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

NMR and crystallographic structures of the FK506 binding domain of human malarial parasite Plasmodium vivax FKBP35

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Crystal structure of the FK506 binding domain of Plasmodium falciparum FKBP35 in complex with FK506

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Small molecule Plasmodium FKBP35 inhibitor as a potential antimalaria agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Quinolone-3-diarylethers: a new class of antimalarial drug.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Thioredoxin reductase and glutathione synthesis in Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Discovery and biochemical characterization of Plasmodium thioredoxin reductase inhibitors from an antimalarial set.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Investigation of a potential mechanism for the inhibition of SmTGR by Auranofin and its implications for Plasmodium falciparum inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Crystal structure of Plasmodium falciparum thioredoxin reductase, a validated drug target

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

21 January 2018

Autophagy in protists.

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Discovery of gene function by expression profiling of the malaria parasite life cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Structural characterization and inhibition of the Plasmodium Atg8–Atg3 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Crystal Structure of Arginase from Plasmodium falciparum and Implications for l -Arginine Depletion in Malarial Infection,

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Structure and function of the methionine aminopeptidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Inhibitors of Plasmodium falciparum methionine aminopeptidase 1b possess antimalarial activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Target identification and validation of novel antimalarials

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

21 January 2018

Aminoacyl-tRNA synthesis

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Cognition, mechanism, and evolutionary relationships in aminoacyl-tRNA synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Structural analysis of malaria-parasite lysyl-tRNA synthetase provides a platform for drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Crystal structure of Plasmodium falciparum phosphoglycerate kinase: Evidence for anion binding in the basic patch

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Specific inhibition of the aspartate aminotransferase of Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Crystal structures of IspF from Plasmodium falciparum and Burkholderia cenocepacia: comparisons inform antimicrobial drug target assessment

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Structure of the (E)-4-hydroxy-3-methyl-but-2-enyl-diphosphate reductase from Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

An Appended Domain Results in an Unusual Architecture for Malaria Parasite Tryptophanyl-tRNA Synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Crystallographic structure of the tetratricopeptide repeat domain ofPlasmodium falciparumFKBP35 and its molecular interaction with Hsp90 C-terminal pentapeptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Crystal structure of Plasmodium falciparum spermidine synthase in complex with the substrate decarboxylated S-adenosylmethionine and the potent inhibitors 4MCHA and AdoDATO

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

The Clp chaperones and proteases of the human malaria parasite Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Structural Insights into the Inactive Subunit of the Apicoplast-localized Caseinolytic Protease Complex of Plasmodium falciparum

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Characterization of a new phosphatase from Plasmodium

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Structures of parasitic CDPK domains point to a common mechanism of activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Structures of Substrate- and Inhibitor-Bound Adenosine Deaminase from a Human Malaria Parasite Show a Dramatic Conformational Change and Shed Light on Drug Selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Designing the next generation of medicines for malaria control and eradication

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Structural biology for developing antimalarial compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240

Acyclic Nucleoside Analogues as Inhibitors ofPlasmodiumfalciparumdUTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20140240