N-myristoyltransferase: a prospective drug target for protozoan parasites (Q37103880)

18 August 2017

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title

N-myristoyltransferase: a prospective drug target for protozoan parasites (English)

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18 August 2017

Edward W Tate

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Robin J Leatherbarrow

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Anthony A Holder

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Paul W Bowyer

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18 August 2017

Deborah F Smith

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18 August 2017

Katherine A Brown

series ordinal

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18 August 2017

publication date

1 March 2008

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18 August 2017

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18 August 2017

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18 August 2017

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18 August 2017

page(s)

402-408

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Trypanosoma brucei ARF1 plays a central role in endocytosis and golgi-lysosome trafficking

18 August 2017

cites work

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A simplified assay for the enzyme responsible for the attachment of myristic acid to the N-terminal glycine residue of proteins, myristoyl-CoA: glycylpeptide N-myristoyltransferase

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Protein kinases as drug targets in trypanosomes and Leishmania

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7 January 2021

Antimalarial drug discovery: targeting protein kinases

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Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics.

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7 January 2021

Acylation of proteins with myristic acid occurs cotranslationally

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7 January 2021

Environmental-dependent acceleration of a developmental switch: the floral transition

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7 January 2021

Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis

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7 January 2021

C-terminal 15 kDa fragment of cytoskeletal actin is posttranslationally N-myristoylated upon caspase-mediated cleavage and targeted to mitochondria

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7 January 2021

Prediction of lipid posttranslational modifications and localization signals from protein sequences: big-Pi, NMT and PTS1

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7 January 2021

Eukaryotic Fatty Acylation Drives Plasma Membrane Targeting and Enhances Function of Several Type III Effector Proteins from Pseudomonas syringae

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7 January 2021

The Pseudomonas syringae pv. tomato DC3000 type III effector HopF2 has a putative myristoylation site required for its avirulence and virulence functions.

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7 January 2021

Mutations of human myristoyl-CoA:protein N-myristoyltransferase cause temperature-sensitive myristic acid auxotrophy in Saccharomyces cerevisiae

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7 January 2021

A Second Mammalian N-Myristoyltransferase

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7 January 2021

Identification and characterization of recombinant and native rat myristoyl-CoA: protein N-myristoyltransferases.

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7 January 2021

Molecular cloning, genomic organization, and biochemical characterization of myristoyl-CoA:protein N-myristoyltransferase from Arabidopsis thaliana

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7 January 2021

Purification and characterization of yeast myristoyl CoA:protein N-myristoyltransferase.

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7 January 2021

Myristoyl-CoA:protein N-myristoyltransferase, an essential enzyme and potential drug target in kinetoplastid parasites.

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7 January 2021

N-terminal N-myristoylation of proteins: prediction of substrate proteins from amino acid sequence

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7 January 2021

The structure of myristoyl-CoA:protein N-myristoyltransferase

1 reference

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7 January 2021

Pre-steady-state kinetic studies of Saccharomyces cerevisiae myristoylCoA:protein N-myristoyltransferase mutants identify residues involved in catalysis

1 reference

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7 January 2021

Structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoylCoA and peptide provide insights about substrate recognition and catalysis

1 reference

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7 January 2021

Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors reveal the functional roles of the N-terminal region

1 reference

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7 January 2021

Antifungals targeted to protein modification: focus on protein N-myristoyltransferase

1 reference

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7 January 2021

Human N-myristoyltransferases form stable complexes with lentiviral nef and other viral and cellular substrate proteins

1 reference

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7 January 2021

Potential role of N-myristoyltransferase in cancer

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7 January 2021

Synthesis and characterization of inhibitors of myristoyl-CoA:protein N-myristoyltransferase

1 reference

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7 January 2021

S-(2-oxopentadecyl)-CoA, a nonhydrolyzable analogue of myristoyl-CoA, is a potent inhibitor of myristoyl-CoA:protein N-myristoyltransferase

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

Metabolic activation of 2-substituted derivatives of myristic acid to form potent inhibitors of myristoyl CoA:protein N-myristoyltransferase

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

Selective peptidic and peptidomimetic inhibitors of Candida albicans myristoylCoA: protein N-myristoyltransferase: a new approach to antifungal therapy

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

Conformationally constrained [p-(omega-aminoalkyl)phenacetyl]-L-seryl-L-lysyl dipeptide amides as potent peptidomimetic inhibitors of Candida albicans and human myristoyl-CoA:protein N-myristoyl transferase

1 reference

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7 January 2021

Genetic and biochemical studies establish that the fungicidal effect of a fully depeptidized inhibitor of Cryptococcus neoformans myristoyl-CoA:protein N-myristoyltransferase (Nmt) is Nmt-dependent.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

Scanning alanine mutagenesis and de-peptidization of a Candida albicans myristoyl-CoA:protein N-myristoyltransferase octapeptide substrate reveals three elements critical for molecular recognition

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

Design and synthesis of novel imidazole-substituted dipeptide amides as potent and selective inhibitors of Candida albicans myristoylCoA:protein N-myristoyltransferase and identification of related tripeptide inhibitors with mechanism-based antifung

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 1.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

Synthesis and biological activities of benzofuran antifungal agents targeting fungal N-myristoyltransferase

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

Crystal structures of Candida albicans N-myristoyltransferase with two distinct inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

Cassette dosing approach and quantitative structure-pharmacokinetic relationship study of antifungal N-myristoyltransferase inhibitors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 2.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 3.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

Synthesis of potent and selective inhibitors of Candida albicans N-myristoyltransferase based on the benzothiazole structure.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

FTR1335 is a novel synthetic inhibitor of Candida albicans N-myristoyltransferase with fungicidal activity

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

Isolation, expression and characterization of the gene for an ADP-ribosylation factor from the human malaria parasite, Plasmodium falciparum

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

Functional analysis of TbARL1, an N-myristoylated Golgi protein essential for viability in bloodstream trypanosomes

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

Kinetoplastid PPEF phosphatases: dual acylated proteins expressed in the endomembrane system of Leishmania

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

Expression of a hydrophilic surface protein in infective stages of Leishmania major

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

Characterisation of a second protein encoded by the differentially regulated LmcDNA16 gene family of Leishmania major

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

Acylation-dependent Protein Export in Leishmania

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

CAP5.5, a life-cycle-regulated, cytoskeleton-associated protein is a member of a novel family of calpain-related proteins in Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

Export of Plasmodium falciparum calcium-dependent protein kinase 1 to the parasitophorous vacuole is dependent on three N-terminal membrane anchor motifs

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

Dual acylation of the 45 kDa gliding-associated protein (GAP45) in Plasmodium falciparum merozoites.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

TbARF1 influences lysosomal function but not endocytosis in procyclic stage Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

N-myristoylation of Arf proteins in Candida albicans: an in vivo assay for evaluating antifungal inhibitors of myristoyl-CoA: protein N-myristoyltransferase

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

N-terminal N-myristoylation of proteins: refinement of the sequence motif and its taxon-specific differences

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

N-Terminal myristoylation predictions by ensembles of neural networks

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

Molecules incorporating a benzothiazole core scaffold inhibit the N-myristoyltransferase of Plasmodium falciparum.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

Characterization and selective inhibition of myristoyl-CoA:protein N-myristoyltransferase from Trypanosoma brucei and Leishmania major

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

Protein fatty acid acylation: enzymatic synthesis of an N-myristoylglycyl peptide

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

Assay of N-myristoyl transferase by selective adsorption of myristoyl-coenzyme A on acidic alumina

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

N-myristoyl transferase assay using phosphocellulose paper binding

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

Cyclohexyl-octahydro-pyrrolo[1,2-a]pyrazine-based inhibitors of human N-myristoyltransferase-1.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

The genome of the kinetoplastid parasite, Leishmania major

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

The Genome of the African Trypanosome Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

The Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas Disease

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200700301

7 January 2021

Identifiers

DOI

10.1002/CMDC.200700301

1 reference

18 August 2017

1 reference