Phospho-p70S6K and cdc2/cdk1 as therapeutic targets for diffuse large B-cell lymphoma (Q37554503)

21 August 2017

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title

Phospho-p70S6K and cdc2/cdk1 as therapeutic targets for diffuse large B-cell lymphoma (English)

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21 August 2017

Xianfeng Frank Zhao

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21 August 2017

Ronald B Gartenhaus

series ordinal

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21 August 2017

language of work or name

English

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publication date

1 September 2009

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Expert Opinion on Therapeutic Targets

21 August 2017

published in

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21 August 2017

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21 August 2017

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21 August 2017

page(s)

1085-1093

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New approach to classifying non-Hodgkin's lymphomas: clinical features of the major histologic subtypes. Non-Hodgkin's Lymphoma Classification Project

21 August 2017

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Phospho-p70S6K/p85S6K and cdc2/cdk1 are novel targets for diffuse large B-cell lymphoma combination therapy

21 January 2018

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Comprehensive copy number and gene expression profiling of the 17q23 amplicon in human breast cancer

21 January 2018

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Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini

21 January 2018

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A single gene encodes two isoforms of the p70 S6 kinase: activation upon mitogenic stimulation

21 January 2018

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21 January 2018

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21 January 2018

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Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site

21 January 2018

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The modular phosphorylation and activation of p70s6k.

21 January 2018

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Regulation of the p70 S6 kinase by phosphorylation in vivo. Analysis using site-specific anti-phosphopeptide antibodies

21 January 2018

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Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity

21 January 2018

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Oncogenes as molecular targets in lymphoma

21 January 2018

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PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

21 January 2018

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Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP.

21 January 2018

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A specific product of phosphatidylinositol 3-kinase directly activates the protein kinase Akt through its pleckstrin homology domain.

21 January 2018

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21 January 2018

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Control of p70 s6 kinase by kinase activity of FRAP in vivo

21 January 2018

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Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites

21 January 2018

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Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro

21 January 2018

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

21 January 2018

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

21 January 2018

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Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

21 January 2018

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Role of S6 phosphorylation and S6 kinase in cell growth

21 January 2018

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Ribosomal S6 kinase signaling and the control of translation

21 January 2018

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3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

21 January 2018

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Phosphorylation and activation of p70s6k by PDK1

21 January 2018

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Identification of the NIMA family kinases NEK6/7 as regulators of the p70 ribosomal S6 kinase

21 January 2018

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Characterization of phosphatidylinositol 3-kinase-dependent phosphorylation of the hydrophobic motif site Thr(389) in p70 S6 kinase 1.

21 January 2018

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A new role for the p85-phosphatidylinositol 3-kinase regulatory subunit linking FRAP to p70 S6 kinase activation.

21 January 2018

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Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin

21 January 2018

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Activation of 70-kDa S6 kinase, induced by the cytokines interleukin-3 and erythropoietin and inhibited by rapamycin, is not an absolute requirement for cell proliferation

21 January 2018

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Constitutive activation of p70S6k in cancer cells

21 January 2018

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Constitutive activation of phosphatidyl-inositide 3 kinase contributes to the survival of Hodgkin's lymphoma cells through a mechanism involving Akt kinase and mTOR.

21 January 2018

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Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma

21 January 2018

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Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma

21 January 2018

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Syk-dependent mTOR activation in follicular lymphoma cells.

21 January 2018

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p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD

21 January 2018

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Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

21 January 2018

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

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Rapamycin-induced G1 arrest in cycling B-CLL cells is associated with reduced expression of cyclin D3, cyclin E, cyclin A, and survivin

21 January 2018

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Rapamycin inhibits cdk4 activation, p 21(WAF1/CIP1) expression and G1-phase progression in transformed mouse fibroblasts

21 January 2018

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A rapamycin derivative (everolimus) controls proliferation through down-regulation of truncated CCAAT enhancer binding protein {beta} and NF-{kappa}B activity in Hodgkin and anaplastic large cell lymphomas.

21 January 2018

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Mammalian target of rapamycin inhibition induces cell cycle arrest in diffuse large B cell lymphoma (DLBCL) cells and sensitises DLBCL cells to rituximab.

21 January 2018

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Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2

21 January 2018

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Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

21 January 2018

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Cell cycle. Confirmational change.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903103833

Control of the G2/M transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903103833

Ran-independent nuclear import of cyclin B1-Cdc2 by importin beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903103833

Nuclear import of Cdk/cyclin complexes: identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1.

21 January 2018

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MPF localization is controlled by nuclear export

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728220903103833

Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903103833

The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex

21 January 2018

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Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase

21 January 2018

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Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728220903103833

High expression of cyclin B1 predicts a favorable outcome in patients with follicular lymphoma

21 January 2018

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Staurosporine-induced G2/M arrest in primary effusion lymphoma BCBL-1 cells

21 January 2018

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Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903103833

Inhibition of cyclin-dependent kinase-2 induces apoptosis in human diffuse large B-cell lymphomas

21 January 2018

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ABT-263 and rapamycin act cooperatively to kill lymphoma cells in vitro and in vivo

21 January 2018

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The farnesyltransferase inhibitor L744832 potentiates UCN-01-induced apoptosis in human multiple myeloma cells

21 January 2018

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Activation of the PI3K/Akt pathway and chemotherapeutic resistance

21 January 2018

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Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine).

21 January 2018

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A p34(cdc2) survival checkpoint in cancer

21 January 2018

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A phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of rapamycin inhibitor, in patients with relapsed or refractory hematologic malignancies

21 January 2018

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Evidence That 3-Phosphoinositide-dependent Protein Kinase-1 Mediates Phosphorylation of p70 S6 Kinasein Vivoat Thr-412 as well as Thr-252

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903103833

p70s6k function is essential for G1 progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903103833

10.1517/14728220903103833

21 January 2018

Identifiers

DOI

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21 August 2017

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