PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase (Q28244045)

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K P Lemon

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A Kazlauskas

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J Blenis

GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit

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language of work or name

English

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publication date

7 July 1994

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published in

Nature

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volume

370

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issue

6484

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page(s)

71-5

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cites work

1 reference

7 January 2021

Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signaling pathways

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7 January 2021

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

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7 January 2021

Phosphoinositide kinases

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7 January 2021

Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase

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7 January 2021

Activation of p70s6k is associated with phosphorylation of four clustered sites displaying Ser/Thr-Pro motifs

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7 January 2021

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

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7 January 2021

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

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7 January 2021

Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase

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7 January 2021

p70s6k function is essential for G1 progression

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7 January 2021

Signal transduction via the MAP kinases: proceed at your own RSK.

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7 January 2021

Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

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7 January 2021

Activation of phosphatidylinositol 3-kinase by insulin

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7 January 2021

Selectivity of phospholipase C phosphorylation by the epidermal growth factor receptor, the insulin receptor, and their cytoplasmic domains

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7 January 2021

Insulin-stimulated GLUT4 translocation is relevant to the phosphorylation of IRS-1 and the activity of PI3-kinase

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7 January 2021

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

1 reference

7 January 2021

Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor

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7 January 2021

Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling

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7 January 2021

Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity

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7 January 2021

Activation of MAP kinases, pp90rsk and pp70-S6 kinases in mouse mast cells by signaling through the c-kit receptor tyrosine kinase or Fc epsilon RI: rapamycin inhibits activation of pp70-S6 kinase and proliferation in mouse mast cells

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7 January 2021

Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini

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7 January 2021

Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

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7 January 2021

Dimensions Publication ID

Identifiers

DOI

10.1038/370071A0

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1023028315

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Fatcat ID

release_om362qpqjveodneawr3cogtoda

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/om362qpqjveodneawr3cogtoda

24 November 2022